Diabetes mellitus and work. Assessment and questionnaires revision

Vicente-Herrero, Ma Teófila; Torre, María Victoria Ramírez-Iñiguez de la; Delgado-Bueno, Santiago

doi:10.1016/j.endien.2019.02.007

Cited by 3 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…T2DM is characterized by hyperglycemia, insulin resistance, and insulin secretion disorders ( 18 , 19 ). Patients with T2DM are always complicated with cardiovascular and cerebrovascular diseases and digestive tract dysfunction due to metabolic disorders and decreased resistance, which seriously affect the quality of life of patients ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study

Kui,

Dong,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundType 2 diabetes mellitus (T2DM) and hearing loss (HL) constitute significant public health challenges worldwide. Recently, the association between T2DM and HL has aroused attention. However, possible residual confounding factors and other biases inherent to observational study designs make this association undetermined. In this study, we performed univariate and multivariable Mendelian Randomization (MR) analysis to elucidate the causal association between T2DM and common hearing disorders that lead to HL.MethodsOur study employed univariate and multivariable MR analyses, with the Inverse Variance Weighted method as the primary approach to assessing the potential causal association between T2DM and hearing disorders. We selected 164 and 9 genetic variants representing T2DM from the NHGRI-EBI and DIAGRAM consortium, respectively. Summary-level data for 10 hearing disorders were obtained from over 500,000 participants in the FinnGen consortium and MRC-IEU. Sensitivity analysis revealed no significant heterogeneity of instrumental variables or pleiotropy was detected.ResultsIn univariate MR analysis, genetically predicted T2DM from both sources was associated with an increased risk of acute suppurative otitis media (ASOM) (In NHGRI-EBI: OR = 1.07, 95% CI: 1.02-1.13, P = 0.012; In DIAGRAM: OR = 1.14, 95% CI: 1.02-1.26, P = 0.016). Multivariable MR analysis, adjusting for genetically predicted sleep duration, alcohol consumption, body mass index, and smoking, either individually or collectively, maintained these associations. Sensitivity analyses confirmed the robustness of the results.ConclusionT2DM was associated with an increased risk of ASOM. Strict glycemic control is essential for the minimization of the effects of T2DM on ASOM.

show abstract

Section: Introductionmentioning

confidence: 99%

Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study

Kui,

Dong,

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus (DM) is a disease carrying high incidence, serious complications, and far-reaching clinical impact. 1 The prevalence of it is about 1 in 10 among people aged 20 to 79 years worldwide in 2021, and its prevalence will further elevate in 2045. 2 Symptoms of DM consist of weight loss, polyphagia, and decreased vision, among others.…”

Section: Introductionmentioning

confidence: 99%

Highly-Expressed MiR-221-3p Distinctly Increases the Incidence of Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus

Zhao,

Pan

2023

Trans. Vis. Sci. Tech.

View full text Add to dashboard Cite

Objective Diabetic retinopathy (DR) is the leading cause of blindness in patients with diabetes mellitus (DM). MiR-221-3p is implicated in microvascular dysfunction in DR, and we explored their relationship. Methods Patients with type 2 diabetes mellitus (T2DM) were allocated to the non-DR (NDR)/nonproliferative DR (NPDR)/proliferative DR (PDR) groups, with their clinical baseline and pathological data collected. The miR-221-3p and VEGF levels were determined by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and ELISA, respectively. Peripheral blood endothelial progenitor cell (EPC) and endothelial cell (EC) ratios were ascertained by flow cytometry. The correlations between miR-221-3p levels and VEGF/EPCs/ECs, the predictive value of serum miR-221-3p levels in DR, and the independent risk factors for DR occurrence in T2DM were analyzed by Pearson's correlation analysis, receiver operating characteristic (ROC) curve, and multifactorial logistic regression analysis. Results Serum miR-221-3p was highly expressed in DR. Clinical severity of DR was positively correlated with miR-221-3p levels. Endothelial function was impaired in DR. Serum miR-221-3p levels in DR were favorably correlated with VEGF and ECs and negatively associated with EPCs. The area under the curve of serum miR-221-3p in evaluating DR occurrence in patients with T2DM was 0.8178 (1.235 cutoff value, 69.62% sensitivity, and 82.35% specificity). High expression of miR-221-3p increased DR incidence in patients with T2DM. Diabetes course, VEGF, EPCs, ECs, and miR-221-3p levels were independent risk factors for DR development in patients with T2DM. Conclusions Serum miR-221-3p levels in patients with DR were positively correlated with VEGF and ECs and negatively linked with EPCs. Highly expressed miR-221-3p distinctly increased DR incidence in patients with T2DM and was an independent risk factor for DR development in patients with T2DM. Translational Relevance This study assessed serum miR-221-3p level and endothelial function indicators (VEGF, EPCs, and ECs) in patients with DR and analyzed the correlation between each indicator. We found that high serum miR-221-3p expression prominently increased the incidence of DR in patients with T2DM and was an independent risk factor for the development of DR in patients with T2DM. This study provided a scientific basis for further clarification of the pathogenesis of DR, and also provided new ideas for clinical prediction and management of DR.

show abstract

“…The diabetes development involves several risk factors, such as genetic predisposition, obesity, pathophysiological and environmental factors and the individual's lifestyle, especially aspects of diet and sedentary lifestyle 4 . Numerous complications can worsen the condition of patients with diabetes, including cardiovascular and renal diseases, neuropathies, retinopathy and limb amputation, and these aggravations are mainly responsible for the increase in morbidity, disability and mortality among diabetic patients 5 .…”

Section: Introductionmentioning

confidence: 99%

Fungal polysaccharides and their hypoglycemic potential to act as an adjuvant in the treatment of diabetes mellitus

Figueroa

Costa

Miranda

et al. 2023

evid.

View full text Add to dashboard Cite

Diabetes mellitus é considerado um grave problema de saúde pública, pois afeta milhões de indivíduos e causa inúmeras complicações. Os constantes efeitos adversos das terapias convencionais para diabetes mellitus têm estimulado pesquisas que buscam novas formas de tratamento, prevenção e controle. Polissacarídeos obtidos de fungos são promissores como adjuvantes no controle do diabetes mellitus. Este estudo é uma revisão de literatura que buscou avaliar as propriedades hipoglicemiantes de polissacarídeos obtidos de fungos e compreender os principais mecanismos de ação envolvidos. Os principais mecanismos relatados nos estudos que resultaram na diminuição da glicemia foram a inibição de enzimas digestivas, como α-amilase e α-glicosidase, ação nas vias de sinalização IRS1, PI3K, JNK1, antioxidante, anti-inflamatória, capacidade hipolipidêmica e estimulação da microbiota intestinal.

show abstract

Diabetes mellitus and work. Assessment and questionnaires revision

Cited by 3 publications

References 31 publications

Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study

Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study

Highly-Expressed MiR-221-3p Distinctly Increases the Incidence of Diabetic Retinopathy in Patients With Type 2 Diabetes Mellitus

Fungal polysaccharides and their hypoglycemic potential to act as an adjuvant in the treatment of diabetes mellitus

Contact Info

Product

Resources

About