Diabetes Mellitus as a Risk Factor for Pancreatic Cancer

Abstract

Pancreatic cancer occurs with increased frequency among persons with long-standing diabetes.

Cigarette smoking, elevated fasting serum glucose, and risk of pancreatic cancer in Korean men

“…45 A meta-analysis of 20 studies conducted a decade ago estimated that individuals with diabetes have a 2-fold greater RR of pancreatic cancer than do individuals without diabetes. 27 A 2005 metaanalysis of cohort and case-control studies yielded an estimate of 1.8 (95% CI 5 1.7-2.0). 2 The estimates of the Korean Cancer Prevention Study were similar, and the RR increased with increasing level of FSG.…”

“…Risk factors for pancreatic cancer are thought to include obesity, [4][5][6][7] nutritional factors, [8][9][10][11][12][13][14][15][16] alcohol drinking, [17][18][19][20][21][22][23] genetic factors 24,25 and a family history 3 of pancreatic cancer. However, the major risk factors that have been consistently reported are age, diabetes [26][27][28][29] and cigarette smoking. 30 Epidemiological studies from European countries and the United States have consistently shown that cigarette smoking is associated with an increased risk of pancreatic cancer, but the dose-response relationship has not been clear due to inconsistent findings among these studies.…”

“…[18][19][20][21][22][23][31][32][33][34][35][36][37][38][39][40][41][42] In addition, recent observational studies have provided consistent evidence for an association of diabetes with increased risk of pancreatic cancer. [27][28][29] To date, however, very few studies have analyzed the potential interaction between smoking and other risk factors, in terms of manifestations of pancreatic cancer. 24,25 The present study, the largest population-based cohort study of pancreatic cancer conducted to date in Korea, provides a unique opportunity to examine the effect of cigarette smoking on pancreatic cancer as well as the interaction between cigarette smoking and diabetes.…”

Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer

“…The association between diabetes mellitus and pancreatic cancer has been evaluated in more than 30 studies (Green and Jensen, 1985;Chow et al, 1995;Everhart and Wright, 1995;Wideroff et al, 1997;Calle et al, 1998), with most indicating a positive relationship. The critical question has been whether diabetes is a true aetiologic factor or a consequence of pancreatic cancer during a prediagnostic stage.…”

“…Hyperinsulinaemia is characteristic of both obesity and non-insulin-dependent diabetes mellitus (NIDDM) (DeFronzo et al, 1997), and may play a key role in pancreatic carcinogenesis (Everhart and Wright, 1995). Among non-diabetics, resistance to insulin action typically increases with increasing BMI, which results in hyperinsulinaemia.…”