Diabetes mellitus as a risk factor for ischemic stroke: a case control study

Abstract

Background: In developed countries, stroke is the third most common cause of mortality, following cancer and coronary heart disease. The increase risk is often seen in individuals with diabetes and is associated with poorer clinical outcomes (including higher mortality). That’s why assessment of risk factors for stroke are important.Methods: This age and sex matched hospital based case control study assessed the risk factors of ischemic stroke in tertiary care hospital for a period of one year. Sample size was calculated for matched case control (1:1 ratio) by n-master software and came out to be 189 pairs. All patients under WHO case definition were enrolled as cases for study purpose, controls were selected from the same hospital with disease other than stroke. Analysis was conducted through calculation of odd ratio (OR) and confidence internal (CI) by using SPSS 22.0 program. Odds ratio (OR) of risk factor was calculated using bivariate analysis.Results: Results revealed that male: female ratio among the case and control was 2.1:1, mean age of case and control were 58.86±13.03 and 58.21±12.67. Out of 189 Case, 59 (31.2%) were suffering from diabetes, while only 39 (20.6%) controls were having diabetes mellitus. P value was 0.02, which is significant.Conclusions: In the present hospital based case control study, it was found that diabetes mellitus was a significant risk factor among the ischemic stroke patients.

Faktor-faktor yang Berhubungan dengan Kejadian Stroke pada Penduduk Usia ≥15 Tahun di Provinsi Daerah Istimewa Yogyakarta (Analisis Data Riskesdas 2018)

“…Hasil penelitian ini sejalan dengan penelitian di India dimana diabetes melitus memiliki peluang 1,75 kali lebih besar untuk menderita stroke dibanding responden tanpa diabetes melitus. 26 Diabetes dapat berkontribusi untuk menyebabkan stroke dalam berbagai mekanisme. Diantaranya, diabetes dapat menyebabkan peningkatkan kekakuan arteri (arterial stiffness) pada usia yang dini, disfungsi endotel vaskular, dan penebalan pada membran basal kapiler.…”

Hubungan Diabetes Melitus Tipe 2 Dengan Stroke Iskemik Pada Pasien Poliklinik Saraf Di Rumah Sakit Budi Kemuliaan Kota Batam Tahun 2021

“…Hasil penelitian ini sesuai dengan penelitian Yang et al (2019) yang menunjukkan diabetes tipe 2 secara signifikan terkait dengan peningkatan risiko infark serebral dan oklusi arteri serebral, tetapi tidak dengan perdarahan intraserebral atau perdarahan subarachnoid di usia lanjut dengan OR (95% CI) dari diabetes tipe 2 adalah 1,29 (1,03, 1,61) untuk infark serebral, 2,03 (1,20, 3,44) untuk oklusi arteri serebral, 0,52 (0,12, 2,21) untuk perdarahan subarachnoid dan 0,78 (0,45, 1,36) untuk perdarahan intraserebral (R. Yang et al, 2019). Penelitian Singh et al (2019) juga menunjukkan terdapat hubungan antara diabetes mellitus dengan kejadian stroke iskemik (p0,02) dan risiko stroke secara signifikan terkait dengan diabetes mellitus (OR=1,75, 95% dari C.I-1.09-2.79) (Singh et al, 2019).…”