Diabetes Mellitus Associated with Epidemic Infectious Hepatitis in Nigeria

Adi, F. C.

doi:10.1007/978-1-4613-2085-2_11

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…10,13 In the nontransplantation setting, it recently was reported that patients with HCV liver disease had a greater prevalence of DM. Large epidemiological studies by Mason et al, 1 Caronia et al, 2 and Adi 22 reported prevalence rates of 20% to 50% for DM in the HCV group compared with 3% to 12% in patients with other causes of liver disease. Similar rates have been reported by others.…”

Section: Discussionmentioning

confidence: 98%

Post–liver transplantation diabetes mellitus: An association with hepatitis C

Aldosary¹

2002

Liver Transplantation

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Section: Discussionmentioning

confidence: 98%

Post–liver transplantation diabetes mellitus: An association with hepatitis C

Aldosary¹

2002

Liver Transplantation

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“…This may be due to hepatic and/or pancreatic damage, which is known to complicate alcoholism [7]. Adi [24], Oli and Nwokolo [25] in Enugu have reported association between liver disease and diabetes in Nigeria. Moderate drinking reduces the risk of diabetes by improving insulin sensitivity [17,26], this may explain the lack of association between diabetes and drinking when both moderate and heavy drinkers were analyzed together against abstainers.…”

Section: Discussionmentioning

confidence: 99%

Type 2 diabetes in adult Nigerians: a study of its prevalence and risk factors in Port Harcourt, Nigeria

Nyenwe

Odia

Ihekwaba

et al. 2003

Diabetes Research and Clinical Practice

162

104

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Objectives: This study aimed to assess the prevalence rates of type 2 diabetes and to determine potential associated risk factors of the disease in Port Harcourt, Nigeria. Research design and methods: Five hundred and two (502) subjects aged above 40 years, obtained by a two-stage cluster sampling technique participated in this survey. Casual (random) plasma glucose estimations were done for all subjects after relevant personal data were obtained. Subjects with casual plasma glucose (CPG) ]/7.0 mmol/l had oral glucose tolerance tests (OGTT) done. Fasting and 2 h post glucose load blood samples were analyzed for plasma glucose levels. Results: Thirty-four (34) subjects had diabetes, giving a crude prevalence rate of 6.8% (CI 0/4.6 Á/9.0%), and standardized rate of 7.9%. The crude prevalence rates were 7.7 and 5.7% for males and females, respectively. Of the 34 diabetic subjects seen, 14 (41.2%) of them were not previously known to have diabetes; 83.7% of these were asymptomatic. Body mass index (BMI) ]/25 kg/m 2 and WHR ]/0.85, family history of diabetes, physical inactivity, heavy consumption of alcohol, older age as well as high social status and Hausa Á/Fulani or Ibibio origin were associated with significantly higher prevalence of type 2 diabetes. Conclusion: The prevalence of type 2 diabetes in Port Harcourt is relatively high. Changing lifestyle associated with industrialization may explain this. A significant proportion of the diabetic subjects are asymptomatic and undiagnosed. The risk factors as shown in our study clearly emphasize the point that type 2 diabetes is to a large extent a preventable disease. #

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“…Significant increase in serum and urinary amylases in patients with AVH has been reported [8,9]. Diabetes mellitus and re duced glucose tolerance have been described during infectious hepatitis [10]. Further more, autopsy findings and/or radiological signs of pancreatic involvement have been demonstrated only in fulminant hepatitis [5][6][7], Also, increase in serum amylase in patients with fulminant hepatic failure has been reported [14,15], We evaluated serum and urinary isoamylase levels together with ultrasonographic appearance of pancreas in patients with AVH of different etiology at the time of hospitalization, 15, and 40 days after the onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Italy. [4][5][6][7], A significant increase in serum and urinary amylases in patients with AVH has been described [8,9], Diabetes mellitus has been found to be associated with infectious hepatitis in Nigeria [10], Aim of this study was to evaluate the occurrence of pancreatic damage in a group of patients with AVH of different aetiology. To this purpose, we evaluated serum and urinary amylases and isoamylases during AVH.…”

mentioning

confidence: 99%

Mild Pancreatic Damage in Acute Viral Hepatitis

et al. 1989

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Whether and to what extent the pancreas is involved in acute viral hepatitis is still unclear. In order to address this issue we evaluated serum and urinary amylase and isoamylase levels in 92 patients with acute viral hepatitis of different etiology and in 60 healthy volunteers. Furthermore, pancreatic structure and volume were evaluated by ultrasound scanning. Significant increase in serum and urinary pancreatic isoamylases was found in 12 and 35% of patients, respectively, in the early stage of the disease. Increase in serum pancreatic isoamylases was found only in patients suffering from B and non-A, non-B hepatitis. Ultrasonographic evaluation did not show any change in pancreatic structure and volume. In conclusion, this study suggests that mild pancreatic damage may occur during viral hepatitis.

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Diabetes Mellitus Associated with Epidemic Infectious Hepatitis in Nigeria

Cited by 3 publications

References 14 publications

Post–liver transplantation diabetes mellitus: An association with hepatitis C

Post–liver transplantation diabetes mellitus: An association with hepatitis C

Type 2 diabetes in adult Nigerians: a study of its prevalence and risk factors in Port Harcourt, Nigeria

Mild Pancreatic Damage in Acute Viral Hepatitis

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