Diabetes Mellitus: fator de risco para toxicidade de medicamentos

Martins, Anna Luiza Chimirri de Limas; Watanabe, Mirian; Fernandes, Sheila Marques; Fonseca, Cassiane Dezoti da; Vattimo, Maria de Fátima Fernandes

doi:10.1590/s1980-220x2017033503347

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Nephrotoxic drugs act directly on tubular cells and vascular endothelium. There is a chemical interaction in favor of cell injury, which generates the release of inflammatory cytokines IL-6, TNF-α and reactive oxygen species such as hydrogen peroxide and superoxide radical (6,8,33,34). Hypoxia sets in and generates an imbalance between vasodilator substances (nitric oxide and prostaglandins) and vasoconstrictors (endothelin, adenosine, vasopressin, angiotensin II and dopamine -1), which are also activated via the endothelium by contrast osmolarity, contrast viscosity and erythrocyte aggregation that results…”

Section: W I T H D R a W Nmentioning

confidence: 99%

WITHDRAWN: L-Carnitine on contrast-induced nephropathy in diabetic rats

de Oliveira,

Couto,

Borges

et al. 2023

Preprint

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Background: The use of contrast media in coronary interventions favors diagnostic success. Contrast-induced nephropathy (CIN) is considered a frequent adverse event in the presence of the risk factor diabetes mellitus (DM). L-Carnitine is a lipid metabolism compound with a possible antioxidant effect. Objectives: to evaluate the effect of L-Carnitine on contrast-induced nephropathy in rats with diabetes mellitus. Method: twenty-eight male Wistar rats (250-300g) were randomized into four groups: Citrate (control); Diabetes (65mg/kg of intravenous streptozotocin); Diabetes+Iodinated contrast (meglumine sodium ioxathalamate 6ml/kg intraperitoneal-i.p, single dose); Diabetes+Iodinated contrast+L-Carnitine (50 mg/kg i.p. administered for 5 days). Physiological parameters were evaluated (weight, feed and water intake, glycemia and ratio of kidney weight to animal weight); renal function (inulin clearance, serum creatinine, urinary NGAL and urinary albumin); renal hemodynamics and oxidative profile (urine peroxides, thiols in renal tissue, thiobarbituric acid reactive substances in urine and urinary nitric oxide). Results: Contrast-induced nephropathy was confirmed by reduced renal blood flow, increased renal vascular resistance, reduced inulin clearance, increased serum creatinine, and urinary NGAL with increased oxidative peroxide and consumption of antioxidant enzymes. L-Carnitine favored the improvement of renal function and hemodynamics with recovery of redox imbalance. Conclusion: the use of L-Carnitine demonstrated a renoprotective and antioxidant effect.

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Section: W I T H D R a W Nmentioning

confidence: 99%

WITHDRAWN: L-Carnitine on contrast-induced nephropathy in diabetic rats

de Oliveira,

Couto,

Borges

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…A maioria dos participantes apresentam sobrepeso, tendo paciente em obesidade de grau III. Logo é preciso fazer o rastreamento dos pacientes para fazer uma identificação precoce dos que apresentam risco para DRC (10,11) .…”

Section: Discussionunclassified

Estratificação de risco para predisposição de doenças renais crônicas em um grupo de idosos

Alfaia

Pantoja²,

Barborsa

et al. 2020

Rev. Enferm. Atual In Derme

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Objetivo: analisar o estilo de vida da população idosa que predispõe as doenças renais crônicas. Método: Esse estudo é descritivo com abordagem quantitativa, realizado com 286 idosos de uma unidade básica de saúde do município de Belém. Resultado :O p-valor é significativo para a correlação de antecedentes x conhecimento. Em relação o escore de predisposição para doença renal a prevalência foi de 40-49,9 pontos, classificando os participantes em grau V para o risco de predisposição de doença renais crônicas. Conclusão: A realização da classificação de risco para doenças renais crônica é uma ferramenta importante para estabelecer um plano terapêutico singular, condizente com a necessidade de cada usuário.

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Diabetes Mellitus: fator de risco para toxicidade de medicamentos

Abstract: The existence of Diabetes Mellitus resulted in an elevation of gentamicin nephrotoxicity, thus confirming the risk factor for drug nephrotoxicity.

Cited by 2 publications

References 23 publications

WITHDRAWN: L-Carnitine on contrast-induced nephropathy in diabetic rats

WITHDRAWN: L-Carnitine on contrast-induced nephropathy in diabetic rats

Estratificação de risco para predisposição de doenças renais crônicas em um grupo de idosos

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