2022
DOI: 10.1111/jdi.13929
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Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma

Abstract: Aims/Introduction The mismatch repair (MMR) protein recognizes DNA replication errors and plays an important role in tumorigenesis, including pancreatic ductal adenocarcinoma (PDAC). Although PMS2, a MMR protein, is degraded under oxidative stress, the effects of diabetes are still unclear. Herein, we focused on whether diabetes affected MMR protein expression in PDAC. Materials and Methods Tissues from 61 surgically resected PDAC subjects were clinicopathologically ana… Show more

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Cited by 2 publications
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“…The pathophysiology of diabetic complications is chronic inflammation, the production of advanced glycation end products and activation of their signaling, increased levels of oxidative stress, and tissue ischemia exacerbated by micro‐ and macroangiopathy, which include some of the triggers of promoter methylation [ 38 , 39 , 40 , 41 , 42 ]. Furthermore, the duration of diabetes changes the intratumoral composition of inflammatory cells in PDAC, which may increase the level of CDH1 promoter methylation [ 43 ]. Thus, additional insults evoked by long‐DM may be involved in promoter methylation in PDAC.…”
Section: Discussionmentioning
confidence: 99%
“…The pathophysiology of diabetic complications is chronic inflammation, the production of advanced glycation end products and activation of their signaling, increased levels of oxidative stress, and tissue ischemia exacerbated by micro‐ and macroangiopathy, which include some of the triggers of promoter methylation [ 38 , 39 , 40 , 41 , 42 ]. Furthermore, the duration of diabetes changes the intratumoral composition of inflammatory cells in PDAC, which may increase the level of CDH1 promoter methylation [ 43 ]. Thus, additional insults evoked by long‐DM may be involved in promoter methylation in PDAC.…”
Section: Discussionmentioning
confidence: 99%