2024
DOI: 10.21203/rs.3.rs-5153518/v1
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Diabetes mellitus impairs the bone regeneration capacity of mesenchymal stem cell-based therapy

Alann Thaffarell Portilho Souza,
Gileade Pereira Freitas,
Helena Bacha Lopes
et al.

Abstract: BACKGROUND Diabetes mellitus (DM) negatively impacts bone tissue, leading to bone loss and increased fracture risk with many in need of additional treatments, and therapy based on mesenchymal stem cells (MSCs) represents a promising treatment for bone defects in patients with diabetes. The present investigation explored the interactions between MSCs from normoglycemic (NG-MSCs) and diabetic (DM-MSCs) donors on osteoblast differentiation and the effects of NG-MSCs on bone regeneration in defects created in dia… Show more

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