Diabetes mellitus in Bardet Biedl syndrome

Abstract

Purpose of reviewBardet Biedl syndrome (BBS) is a rare disease characterized by obesity and hyperphagia. Despite the very high prevalence of paediatric and adult obesity in this population, the prevalence of diabetes mellitus is not well described.Recent findingsStudies in small and moderately large cohorts suggest a high prevalence of traditional risk factors for diabetes mellitus in people with BBS. People with BBS appear to have a high prevalence of insulin resistance and metabolic syndrome. Small cohort studies have identified high rates of sleep disordered breathing, including sleep apnoea syndrome. Recent research has characterized traditional behavioural risk factors such as sleep hygiene and physical inactivity in people with BBS. High rates of insufficient sleep and prolonged sedentary time suggest behavioural targets of interventions to treat or prevent diabetes mellitus. Hyperphagia, likely caused by defects in the hypothalamic melanocortin-4 receptor (MC4R) neuronal pathway, pose additional challenges to behavioural interventions to prevent diabetes mellitus.SummaryUnderstanding the prevalence of diabetes mellitus and other metabolic disorders in people with BBS and the impact of traditional risk factors on glucose regulation are important to developing effective treatments in this population.

The Role of the Ophthalmic Genetics Multidisciplinary Team in the Management of Inherited Retinal Degenerations—A Case-Based Review

“…Quality and access of care for patients with multisystem genetic disease, such as BBS, may be significantly fragmented and the prevalence of syndromic IRD conditions is great enough to warrant dedicated multidisciplinary clinics (e.g., Usher syndrome 18% of RP and BBS 5% of RP) [28]. The BBS genetic diagnosis also allowed updated diabetic aetiology (in association with metabolic syndrome) rationalizing referral to a specialist endocrinologist [29]. AR inheritance was confirmed, in keeping with known BBS cases, and post-test genetic counselling of the low transmission risk to offspring was conveyed to the patient.…”