Diabetes mellitus in Egypt: risk factors, prevalence and future burden

Herman, William H.; Aubert, Ronald E.; Ali, Mohammad A.; Sous, E.S.; Badran, Ahmed

doi:10.26719/1997.3.1.144

Cited by 19 publications

(4 citation statements)

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“…On the other hand, the prevalence of undiagnosed DM in this study was lower than results of East Gojjam(11.5%), Metu(12.3%), Iraq (11%), Tamil Nadu(11.1%),Urban areas of Egypt (20%) [ 23 , 39 , 42 – 44 ]. These difference in prevalence might be possibly associated with socio-cultural characteristics, lifestyles, healthcare-seeking behavior, and health infrastructures [ 45 ].…”

Section: Discussioncontrasting

confidence: 79%

“…The impact of physical activity on reducing the risk of developing undiagnosed diabetes is clear because, during physical activity, glucose uptake into active muscles increases by increasing insulin sensitivity and allowing muscle cells to use glucose efficiently. Physical activity combined with moderate weight loss has been shown to reduce the risk of type 2 DM by up to 58% in high-risk populations [44]. The study also found that adults who led a sedentary lifestyle were more likely to develop UDM than their peers.…”

Section: Plos Onementioning

confidence: 77%

“…Physical activity combined with moderate weight loss has been shown to reduce the risk of type 2 DM by up to 58% in high-risk populations [ 44 ]. The study also found that adults who led a sedentary lifestyle were more likely to develop UDM than their peers.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of undiagnosed diabetes mellitus and associated factors among adult residents of Mizan Aman town, Southwest Ethiopia: Community-based cross-sectional study

Atrese,

Fekadu,

Kune

et al. 2024

PLoS ONE

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Background Diabetes mellitus continues to be a significant global public health concern, and it is currently a public health issue in developing nations. In Ethiopia, about three fourth of adult population with diabetes are unaware of their diabetic condition. However, there is a limited research on this specific topic particularly in the study area. Objective To assess prevalence of undiagnosed diabetes mellitus and its associated factor among adult residents of Mizan Aman town, south West Ethiopia. Methods and material A community-based cross-sectional study was conducted from May 23 to July 7, 2022, on 627 adult residents of Mizan Aman town. A multi stage sampling technique was used to obtain 646 study units. Interviewer-administered structured questionnaires were employed to gather socio-demographic and behavioral data. Anthropometric measurements were obtained and blood samples were taken from each participants. The fasting blood glucose level was measured after an 8-hour gap following a meal, using a digital glucometer to analyze a blood sample. Data were cleaned and entered into Epi-data v 3.1 and exported to SPSS v. 26 for analysis. Bi-variable analysis was done to select candidate variables and multivariable logistic regression model was fitted to identify independent predictors of undiagnosed diabetes mellitus. Adjusted odds ratio (AOR) with 95% CI was computed and variables with p-value < 0.05 were declared to be predictors of undiagnosed diabetes mellitus. Results The study revealed that, the overall magnitude of undiagnosed diabetes mellitus was 8.13% (95% CI: 6.1, 10.6). Predictors of undiagnosed diabetes mellitus were; physical activity level less than 600 Metabolic equivalent/min per week (AOR = 3.39, 95%CI 1.08 to 10.66), family history of diabetes mellitus (AOR = 2.87, 95% CI 1.41, 5.85), current hypertension(AOR = 2.9, 95% CI 1.26, 6.69), fruit consumption of fewer than three servings per week(AOR = 2.64, 95% CI 1.18 to 5.92), and sedentary life(AOR = 3.33, 95% CI 1.63 to 6.79). Conclusion The prevalence of undiagnosed diabetes mellitus was 8.13%. Physical inactivity, family history of diabetes mellitus, current hypertension, sedentary life, and fruit servings fewer than three per week were independent predictors of undiagnosed diabetes mellitus.

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Section: Discussioncontrasting

confidence: 79%

Section: Plos Onementioning

confidence: 77%

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Prevalence of undiagnosed diabetes mellitus and associated factors among adult residents of Mizan Aman town, Southwest Ethiopia: Community-based cross-sectional study

Atrese,

Fekadu,

Kune

et al. 2024

PLoS ONE

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“…For instance, between 1995 and 2025, the number of diabetic patients is expected to increase by 170% in the developing countries, compared to only 42% in developed ones [2]. In Egypt, the WHO reported that 5%-9.9% of the total population have diabetes mellitus [3] by 2030, it is estimated to have 6.7 million diabetic patients in Egypt [4].…”

Section: Introductionmentioning

confidence: 99%

Health and Knowledge Progress among Diabetic Patients after Implementation of a Nursing Care Program Based on Their Profile

Ali¹

2011

J Diabetes Metab

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Endocrine Imbalance Associated With Proteome Changes in Diabetes

Khairallah

Farag

Johar

et al. 2017

J of Cellular Biochemistry

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The dynamics of cellular metabolism involves rapid interactions between proteins and nucleic acids, proteins and proteins, and signaling. These involve the interactions with respect to the sulfur bond, noncovalent electrostatic interactions, protein structure stabilization and protein-ligand binding, weak electrostatic interactions in proteins, oxygen radicals that initiate a change in conformation and a chain of events. We review a development in molecular medicine that is a very promising work in progress. We also review the current and future research methods involving mitochondria. Long-term effects of diabetes include glycation of proteins, for example, glycohemoglobin (HbA1c), increased risk of cardiovascular diseases, atherosclerosis, retinopathy, nephropathy, and neurological dysfunctions. Tissues are exposed to significant quantities of highly reactive chemical species including nitric oxide NO and reactive oxygen species ROS over months to years, to an extent generated by mitochondrial activities. The reactions of NO can be broadly discussed with reference to three main processes which control their fate in biological systems: (1) diffusion and intra-cellular consumption; (2) autooxidation to form nitrous anhydride N O ; and (3) reaction with superoxide O2 - to form peroxynitrite ONOO-. Reactive nitrogen species produced by macrophages and neutrophils in the interstitial space, with emphasis on NO, N O , ONOO-, and nitrogen dioxide radicals NO generate protein and DNA damage. Serum thiol (-SH) groups act as an important extracellular scavenger of peroxides and are therefore helpful in protecting the surrounding tissues. The events described here are a homeostatic endocrine imbalance that is associated with proteostasis. The advances we have seen in untangling this web of interactions are sure to continue at a breathtaking pace. J. Cell. Biochem. 118: 3569-3576, 2017. © 2017 Wiley Periodicals, Inc.

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Diabetes mellitus in Egypt: risk factors, prevalence and future burden

Cited by 19 publications

References 0 publications

Prevalence of undiagnosed diabetes mellitus and associated factors among adult residents of Mizan Aman town, Southwest Ethiopia: Community-based cross-sectional study

Prevalence of undiagnosed diabetes mellitus and associated factors among adult residents of Mizan Aman town, Southwest Ethiopia: Community-based cross-sectional study

Health and Knowledge Progress among Diabetic Patients after Implementation of a Nursing Care Program Based on Their Profile

Endocrine Imbalance Associated With Proteome Changes in Diabetes

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