Diabetes Mellitus is Associated With Higher COVID-19 Mortality Rates in Sub-Saharan Africa: A Systematic Review and Meta-analysis

Bepouka, Ben; Odio, Ossam; Mangala, Donat; Mayasi, Nadine; Mandina, Madone; Longokolo, Murielle; Makulo, J.R.; Mbula, Marcel; Kayembe, Jean Marie; Situakibanza, Hippolyte

doi:10.7759/cureus.26877

Cited by 5 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The death rate for COVID-19 patients with DM and other diseases is much higher than for patients with DM alone or DM with hypertension, a trend that can be caused by several factors. A systematic review and meta-analysis study by Bepouka et al highlighted that DM is associated with a pro-inflammatory environment (Bepouka et al, 2022), which triggers a cytokine storm (Azhar et al, 2021), exacerbating mortality in COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

Survival analysis of diabetes mellitus and cardiovascular patients with COVID-19: a secondary data analysis

Nugroho,

Fadlilah,

Susanto

et al. 2024

Public Health of Indonesia

View full text Add to dashboard Cite

Background: Patients with diabetes mellitus (DM) and cardiovascular disorders who suffer from COVID-19 may have an increased risk of death. Objective: This study aims to analyze the time of death and influencing factors in patients with DM and cardiovascular disorders with COVID-19. Methods: We used a retrospective observational cohort study using medical records of COVID-19 patients treated at Dr Soeradji and Penembahan Senopati hospitals from March 2020 to June 2022. There were 2,959 participants: patients without comorbidities, with DM, and with cardiovascular problems. We extracted sociodemographic and clinical data on patient characteristics using medical records. Data analysis used Kaplan-Meier and Cox regression analysis to estimate survival probability and investigate predictors of death with a 5% significance level. Results: The median survival time was highest in the group without comorbidities (70.00) and lowest in the DM+others group (21.75). Years of treatment, age, presence of comorbidities, and type of hospital were related to the survival rate of COVID-19 patients (p<0.05). Diabetes mellitus and cardiovascular system disorders are significantly associated with survival of COVID-19 patients (p<0.001). There were significant differences between patients without cardiovascular disorders and patients with cardiovascular disorders (Non-Hypertension, Hypertension, and Hypertension + Others) adjusted by year, gender, age, and hospital type (p<0.001). There were significant differences between patients without DM and patients with DM (DM only, DM+Hypertension, and DM+Others) adjusted by year, gender, age, and hospital type(p<0.001). Conclusion: Years of treatment, age, gender, comorbid DM, and cardiovascular problems are associated with the survival rate of COVID-19 patients. Older age, DM patients who have comorbidities other than hypertension, and patients with cardiovascular issues other than hypertension show a greater risk of death than other groups. Key words: COVID-19, Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Survival Rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Survival analysis of diabetes mellitus and cardiovascular patients with COVID-19: a secondary data analysis

Nugroho,

Fadlilah,

Susanto

et al. 2024

Public Health of Indonesia

View full text Add to dashboard Cite

show abstract

“…Evidence demonstrates that the COVID-19 pandemic also causes poor diabetes management, the progression of prediabetes to diabetes, an increase in the number of newly diagnosed diabetics, and a rise in corticosteroid-induced diabetes [20]. Diabetes that is poorly managed exacerbates the severity of COVID-19 and is linked to an increase in morbidity and mortality [23]. Microvascular and macrovascular problems, infection, and early death are all possible outcomes in diabetic patients, irrespective of the duration of the disease.…”

Section: Discussionmentioning

confidence: 99%

Persistence of Symptoms Following Infection With COVID-19 Among Patients With Type 1 and Type 2 Diabetes Mellitus in Saudi Arabia

Abduljabbar,

Alhawsawi,

Aldharman

et al. 2023

Cureus

View full text Add to dashboard Cite

Background: In Saudi Arabia, information on the persistence of COVID-19-related complications in diabetic patients, their associations with the type of diabetes mellitus (DM), and the role of uncontrolled DM in the complications remains elusive. This study aims to fill this gap. This study aimed to examine the persistence of COVID-19 complications in diabetic patients.Method: A simple randomized, cross-sectional, questionnaire-based study among patients with type 1 and 2 DM following infection with COVID-19 in Saudi Arabia.Result: In the present study, a total of 674 participants were included. Among the COVID-19 symptoms, fatigue (65.6%) was reported the most frequently, followed by headache (62.3%) and cough (59.8%). About 44% of patients reported high blood sugar levels, including 25.5% with elevated fasting (>126 mg/dL) and 18.5% with elevated postprandial (>200 mg/dL) glucose levels. We also report that age > 55 years [OR= 1.66 (1.01-2.56), p=0.045], anti-diabetic medications p=0.022], multiple comorbidities , p=0.005], chest pain [OR= 2.54 (0.96-3.81), p=0.003], and joint pain [OR= 1.64 (0.73-2.94), p=0.025] were independently associated with COVID-19-related complications in diabetic patients. Conclusion:The most common persistent symptoms in diabetic patients with COVID-19 infection are fatigue, headaches, and cough. Advanced age and use of antidiabetic medications were independently associated with COVID-19-related complications in diabetic patients.

show abstract

“…Due to the coronavirus disease's (COVID - 19) swift global expansion in 2019, The World Health Organization (WHO) classified COVID -19 as a pandemic on March 11th, 2020. COVID-19 has killed 4 699 359 people and infected 229 415 774 people worldwide, with a case fatality rate of 2.5 percent [5]. According to WHO Coronavirus Dashboard for COVID -19 prognosis, around 80% of cases have mild illnesses, 14% have severe illnesses, and 5% have critical illnesses.…”

Section: Introductionmentioning

confidence: 99%

Association of diabetes with severity and outcome of COVID - 19 positive patients: a retrospective cohort study in King Abdullah Medical Complex, Jeddah, Saudi Arabia

Albishi¹,

Mehrin²

2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Introduction: The Corona Virus Disease 19 (COVID-19) is a pandemic infectious disease caused by the novel coronavirus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). Almost 8 million instances of the illness were confirmed, and there were over 450,000 fatalities. We aim to explore diabetes as a risk factor associated with the severity and outcome of hospital-admitted COVID-19 positive cases. Method: It is a hospital-based retrospective cohort study of hospital admitted RT-PCR COVID positive cases from March to June 2020. Data were outlined using mean and standard deviation (SD) for quantitative variables; categorical sociodemographic data were compared by disease severity and outcome by Pearson’s Chi-square test (X2). Univariate and multivariate logistic regression analyses were used to estimate the risk factor associated with disease severity and outcome of the patients. Result: Of the 224 diagnosed COVID positive patients, 74 (33.04%) have diabetes. Among these 74 COVID-positive cases with diabetes, 52 (43.70%) cases have severe to critical conditions. Both univariate (OR: 2.87, 95% C.I, 1.58 – 5.20; p = 0.00) and multivariate (aOR: 2.76, 95% C.I, 1.34 – 8.42; p = 0.00) analysis show diabetes has a significant association with severity of COVID infection. Regarding the outcome of hospital admitted COVID patients with diabetes, 52 (28.26%) were discharged alive after recovery from COVID infection. In the univariable (OR: 3.16, 95% C.I, 1.57 – 6.38; p = 0.00) and multivariable (aOR: 3.12, 95% C.I, 1.15 – 8.42; p = 0.02) analysis, diabetes has been significantly associated with the outcome of hospital admitted COVID cases. Conclusion: Our study identified diabetes as a risk factor for increased severity of COVID positive cases. Risk factors like older age and obesity also significantly predict COVID-19 disease progression.

show abstract

Diabetes Mellitus is Associated With Higher COVID-19 Mortality Rates in Sub-Saharan Africa: A Systematic Review and Meta-analysis

Cited by 5 publications

References 35 publications

Survival analysis of diabetes mellitus and cardiovascular patients with COVID-19: a secondary data analysis

Survival analysis of diabetes mellitus and cardiovascular patients with COVID-19: a secondary data analysis

Persistence of Symptoms Following Infection With COVID-19 Among Patients With Type 1 and Type 2 Diabetes Mellitus in Saudi Arabia

Association of diabetes with severity and outcome of COVID - 19 positive patients: a retrospective cohort study in King Abdullah Medical Complex, Jeddah, Saudi Arabia

Contact Info

Product

Resources

About