Diabetes mellitus is associated with early chronic venous disorder of the lower extremities in Chinese patients with cardiometabolic risk factors

Zhong, Jian; Chen, Jing; Zhao, Zhigang; He, Hongbo; Yan, Zhencheng; Liu, Daoyan; Zhu, Zhiming; Ni, Yinxing

doi:10.1002/dmrr.2551

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…general complications that inflict important health care costs and reduce the patient's quality of life (16). One recent study demonstrated that female subjects with cardiometabolic risk factors or female diabetic patients are at greater risk of developing early chronic venous disorder than the male subjects (17), nevertheless the factors that determine whether a given patient will progress from mild to more severe form of CVD remain largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Impact of chronic venous disease on quality of life: Results of vein alarm study

et al. 2018

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Chronic venous disease (CVD) affects millions of people and negatively impacting the patient's quality of life (QoL) and most of the patients are diagnosed with CVD in advanced stages. The impact of newly diagnosed CVD on QoL has not been evaluated by other studies in Romania. The aim of this study was to assess the QoL for adult patients newly diagnosed with CVD addressing to the General Practitioner's (GP) office in Romania between June to August 2016. Patients included in the study were adult, signing the inform consent form, newly diagnosed with CVD or patients diagnosed with CVD, without CVD treatment the past 6 months. Data on demographic distribution, risk factors, clinical profiles, CVD symptomatology, QoL parameters, as well as pharmacological management practice were collected. The study included 1,893 patients (79.08% females) with 50.4% of patients in the age group 51-70 years. The most frequent CVD symptoms reported, were heavy leg sensation (85.74%), swelling of the feet (77.28%) and pain (73.11%). The most frequent CVD signs were telangiectasia and reticular veins (79.19%), varicose veins (65.77%) and edema (53.35%). The clinical, aetiological, anatomical and pathophysiological (CEAP) classification placed most of the patients in C3 class (31.85%), followed by C2 class (28.00%), C1 class (21.02%) and C4a (8.87%). Most of the patients reported 'low' or 'moderate' intensity of the CVD symptoms. QoL was affected for most of the patients at 'a mild' or 'moderate' degree, being noticed as a significant negative impact on physical, psychological, and social functioning components of QoL, correlated with CEAP class (P<0.001). Data regarding correlation of CEAP class, CVD symptoms and impact on QoL identified a significant correlation between all analyzed components (P<0.001). Study results prove that CVD diagnosis was established with relative delay and CVD is negatively affecting patients' QoL. Additional research will be needed to identify the long-term impact of CVD on QoL of the affected patients and their families.

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Section: Discussionmentioning

confidence: 99%

Impact of chronic venous disease on quality of life: Results of vein alarm study

et al. 2018

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“…Many "Civilization Diseases" such as metabolic syndrome, coronary artery disease (CAD), hypertension, diabetes mellitus (DM), allergic diseases, non-alcoholic fatty liver disease, psoriasis, gout, etc., have similar metabolic disorders such as hyperlipidemia/dyslipidemia, hyperglycemia, hyperinsulinemia, hypercortisolemia, hyperuricemia, microalbuminuria, which can be signs of AS [ 4 , 5 ]. In this case, the problem of clinical solution AS and its clinical species are socially significant [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial

Oshakbayev

Dukenbayeva

Otarbayev

et al. 2015

Nutr J

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BackgroundThe prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.MethodsA randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100–150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows version 17.0.ResultsThe weight loss subgroup lost ranging between 7-20 % from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.ConclusionsThe weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat.Trial international registrationClinicalTrials.gov NCT01700075.Trial national registrationState registration is # 0109RK000079, code is O.0475 at the National Center for Scientific and Technical Information of the Republic of Kazakhstan.

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Ferumoxytol-enhanced MR venography for mapping lower-extremity venous networks and evaluating varicose veins in patients with diabetes

Liu,

Cao,

Wang

et al. 2024

Eur Radiol

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Diabetes mellitus is associated with early chronic venous disorder of the lower extremities in Chinese patients with cardiometabolic risk factors

Cited by 5 publications

References 23 publications

Impact of chronic venous disease on quality of life: Results of vein alarm study

Impact of chronic venous disease on quality of life: Results of vein alarm study

Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial

Ferumoxytol-enhanced MR venography for mapping lower-extremity venous networks and evaluating varicose veins in patients with diabetes

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