Diabetes mellitus is associated with subnormal serum levels of free testosterone in men

Rhoden, Ernani Luı́s; Ribeiro, Eduardo Pontual; Telöken, Cláudio; Souto, Carlos Ary Vargas

doi:10.1111/j.1464-410x.2005.05728.x

Cited by 85 publications

(64 citation statements)

References 32 publications

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“…This observation has been confirmed by several previous studies (6,16,17,18,19). Low testosterone levels are common in patients with T2DM.…”

Section: Resultssupporting

confidence: 79%

“…Cross-sectional epidemiological studies have reported a direct correlation between plasma testosterone and insulin sensitivity (2), and low testosterone levels have been associated with an increased risk of T2DM, which has been illustrated by androgen deprivation in men with prostate carcinoma (3). Several studies have suggested that men with low testosterone are at a greater risk of developing T2DM and may even predict the onset of diabetes (4)(5)(6)(7)(8). A systematic review of 43 studies including 6427 men by Ding, et al suggested that higher plasma levels of testosterone were associated with lower risk of T2DM and vice versa (9).…”

Section: Introductionmentioning

confidence: 99%

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Serum testosterone in males with newly diagnosed type 2 diabetes mellitus and microvascular complications

Bajaj

Srivastava

Varma

et al. 2016

Sri Lanka J. Diabetes Endocrinol. Metab.

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“…This observation has been confirmed by several previous studies (6,16,17,18,19). Low testosterone levels are common in patients with T2DM.…”

Section: Resultssupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Serum testosterone in males with newly diagnosed type 2 diabetes mellitus and microvascular complications

Bajaj

Srivastava

Varma

et al. 2016

Sri Lanka J. Diabetes Endocrinol. Metab.

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“…Rhoden et al [22] also demonstrated that subnormal free testosterone concentration had a stronger correlation with the presence of diabetes mellitus than subnormal total testosterone concentration.…”

Section: Discussionmentioning

confidence: 94%

Low Serum Testosterone Concentration in Middle-aged Men with Type 2 Diabetes

et al. 2007

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Abstract. Low concentrations of endogenous androgens have been linked with insulin resistance and atherosclerosis. Men with diabetes have been reported to have lower serum testosterone concentration than non-diabetic men; however, there has never been a large study. The aim of this study was to investigate if endogenous androgen concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men, and to identify what factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Serum free testosterone concentrations were measured in 524 healthy men and in 331 consecutive Japanese men with type 2 diabetes between 40 and 69 years old. In addition, we investigated the relationships between serum free testosterone concentration and luteinizing hormone (LH) concentration as well as major cardiovascular risk factors including age, blood pressure, plasma lipid concentration, glycemic control (HbA 1c ), and BMI. Serum free testosterone concentrations were lower in men with type 2 diabetes than in healthy men in the 40-49 years group (10.9 ± 3.3 vs. 14.0 ± 3.6 pg/ml, P<0.0001), in the 50-59 years group (10.4 ± 3.2 vs. 12.1 ± 2.9 pg/ml, P<0.0001), and in the 60-69 years group (9.5 ± 2.6 vs. 10.5 ± 2.9 pg/ml, P = 0.0104). A negative correlation was found between serum free testosterone and LH concentrations (r = -0.326, P<0.0001). In conclusion, serum free testosterone concentration is certainly lower in a relatively large number of Japanese patients with type 2 diabetes compared with healthy men with each decade of life between 40 and 69 years old.

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“…8 A Australia study reported that MHG prevalence 43% of type 2 diabetes patients with TT levels <288 ng/dl, while in the United Kingdom, MHG prevalence 17% with TT<231 ng/dl and 34% in Brazilian study by using free testosterone. [9][10][11] In Arabic world, MHG defined as TT less than 300 ng/dl was estimated to be 36.5% in patient with type 2 DM. 8 A recent study from Egypt reported 33.2% HG in type 2 diabetes patients.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and predictors for low total testosterone levels among male type 2 diabetic patients: an Egyptian experience

Aboelnaga

Elshahawy

2016

Int J Res Med Sci

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INTRODUCTIONDiabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030.1 On the other hand, Male hypogonadism (MHG) is a clinical syndrome that results from failure to produce physiological concentrations of testosterone. 2MHG is significantly associated with various comorbidities reduced libido, erectile dysfunction, increased adiposity, low energy and fatigue.3 Muscle weakness and low bone mass, Depression, anxiety loss of libido, and erectile dysfunction and decreased quality, abnormal lipid profile, CVS pathophysiologic change. [4][5][6][7] The association between low serum testosterone (LST) and diabetes (DM) has recently received substantial attention; studies have reported that male patients with ABSTRACT Background: Diabetes mellitus (DM) affects an estimated 285 million people worldwide. This number is expected to reach 438 million by the year 2030. The aim of this study was to determine the prevalence of male hypogonadism among Egyptian patients with type 2 diabetes and to identify the risk factors may be associated with low serum testosterone concentrations in men with type 2 diabetes. Methods: 140 male patients with type 2 diabetes were recruited in this cross-sectional study. This study WAS conducted from January 2012 to January 2016 in the endocrinology and metabolism unit, Mansoura University, Egypt. Results: We found 48 (34.2%) patients with hypogonadism (defined as TT ≤300 ng/dl) among 140 male patients with type 2 diabetes. 7 out of 48 (14.5%) patients with TT ≤300 ng/dl had high abnormal gondotrophins hormones levels while 41 patients out of 48 (85.5%) had normal gondotrophins hormones levels. We found BMI, WC, Hba1c, UACR, retinopathy ratio, nephropathy ratio, smoker ratio and patient on insulin therapy ratio were increased in the low TT group with statistically significance, but non statistically significant difference in age, diabetic duration, FSH, LH, Prolactin and lipid profile. In this study by using Pearson correlation, we found a statistically significant correlation between TT levels with BMI, WC, FSH, LH, Hba1c, and UACR (P value<0.05). Also by using stepwise multiple regression analysis, we found BMI, WC, LH, Hba1c, and UACR were statistically significant predictors of TT levels. In logistic regression analysis, we found Hba1c, UACR, and WC were statistically significant risk factors for MHG. Conclusions: Visceral obesity, higher Hba1c, and degree of albuminuria are independent risk factors for hypogonadism in Egyptian male patients with type 2 diabetes.

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Diabetes mellitus is associated with subnormal serum levels of free testosterone in men

Cited by 85 publications

References 32 publications

Serum testosterone in males with newly diagnosed type 2 diabetes mellitus and microvascular complications

Serum testosterone in males with newly diagnosed type 2 diabetes mellitus and microvascular complications

Low Serum Testosterone Concentration in Middle-aged Men with Type 2 Diabetes

Prevalence and predictors for low total testosterone levels among male type 2 diabetic patients: an Egyptian experience

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