Diabetes Mellitus May Increase Risk for Idiopathic Pulmonary Fibrosisa

Enomoto, Tatsuji; Usuki, Jiro; Azuma, Arata; Nakagawa, Takashi; Kudoh, Shoji

doi:10.1378/chest.123.6.2007

Cited by 140 publications

(124 citation statements)

References 15 publications

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“…In multivariable analysis adjusting for variables previously associated with IPF, HT, or both, including BMI, 12 smoking history, 13,14 DM, 15 and GER, 16 along with chronic corticosteroid use, HT remained signifi cantly associated with IPF (OR, 2.7; 95% CI, 1.31-5.54; P 5 .01). HT was identifi ed in 13% of male case patients compared with 4.1% of male control subjects and 28% of female case patients compared with 16% of female control subjects.…”

Section: Resultsmentioning

confidence: 92%

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Oldham

Kumar

Lee

et al. 2015

CHEST

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BACKGROUND:A signifi cant minority of patients with idiopathic pulmonary fi brosis (IPF) display features of autoimmunity without meeting the criteria for overt connective tissue disease. A link between IPF and other immune-mediated processes, such as hypothyroidism (HT), has not been reported. In this investigation, we aimed to determine whether HT is associated with IPF and if outcomes diff er between patients with IPF with and without HT.

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Section: Resultsmentioning

confidence: 92%

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Oldham

Kumar

Lee

et al. 2015

CHEST

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“…arrhythmia and atrial fibrillation [26,28,48,75,96,117,118] figure 12) and weight disorders [10,23,26,125,131,134,137] (online supplementary table S14)) among patients with IPF. IHD was the most frequently reported cardiovascular comorbidity (reported in 24 papers).…”

Section: Cardiovascular and Metabolic Conditionsmentioning

confidence: 99%

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

et al. 2015

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Idiopathic pulmonary fibrosis (IPF) is associated with a fatal prognosis and manifests in patients over 60 years old who may have comorbidities. The prevalence and impact of comorbidities on the clinical course of IPF is unclear.This systematic literature review examined the prevalence of comorbidities and mortality associated with comorbidities in IPF patients. Relevant observational studies published in English from January 1990 to January 2015 identified via MEDLINE and EMBASE were included; bibliographies of articles were also searched.Among the 126 studies included, prevalence of pulmonary hypertension (PH) was 3-86%, 6-91% for obstructive sleep apnoea, 3-48% for lung cancer and 6-67% for chronic obstructive pulmonary disease (COPD). Nonrespiratory comorbidities included ischaemic heart disease (IHD) (3-68%) and gastrooesophageal reflux (GER) (0-94%). Mortality was highest among patients with IPF and lung cancer. Most studies assessed relatively small samples of patients with IPF.PH, COPD, lung cancer, GER and IHD are significant comorbidities; differences in IPF severity, case definitions and patient characteristics limited the comparability of findings. The identification and prompt treatment of comorbidities may have a clinically significant impact on overall outcome that is meaningful for patients with IPF. @ERSpublications Identification and prompt treatment of comorbidities has a clinically significant impact on outcome for IPF patients

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“…In addition, comorbidities, and the medications prescribed for them, can often contribute to symptoms and thus hamper diagnosis and treatment. 71 Vascular or coronary artery disease, obstructive sleep apnea, diabetes, [71][72][73][74] corticosteroid-associated osteoporosis, and sarcopenia are commonly observed in patients with IPF. [75][76][77][78][79][80][81] The incidence of and mortality risk associated with pulmonary hypertension (PH), a common feature of advanced IPF, increases in individuals .…”

Section: Treatmentmentioning

confidence: 99%

Workshop on Idiopathic Pulmonary Fibrosis in Older Adults

Castriotta

Eldadah

Foster

et al. 2010

Chest

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T he aging lung loses mass and undergoes several functional and structural changes ( Table 1 ). Lung function declines with age, as shown by changes in gas exchange and airfl ow limitation ( Fig 1 ). Older adults, defi ned as those aged Ն 60 years, become more rapidly limited during exercise, and 50% of adults . 70 years of age become exercise-limited by dyspnea, compared with only 20% of younger adults. Abbreviations: EBV 5 Epstein-Barr virus; EMT 5 epithelial-mesenchymal transition; ER 5 endoplasmic reticulum; GERD 5 gastroesophageal refl ux disease; IPF 5 idiopathic pulmonary fi brosis; MSC 5 mesenchymal stem cell; PH 5 pulmonary hypertension; SP-C 5 surfactant protein C; TERT 5 telomerase reverse transcriptase; TGF-b 5 transforming growth factor b ; UIP 5 usual interstitial pneumonia

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Diabetes Mellitus May Increase Risk for Idiopathic Pulmonary Fibrosisa

Cited by 140 publications

References 15 publications

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Thyroid Disease Is Prevalent and Predicts Survival in Patients With Idiopathic Pulmonary Fibrosis

Comorbidities in idiopathic pulmonary fibrosis patients: a systematic literature review

Workshop on Idiopathic Pulmonary Fibrosis in Older Adults

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