Diabetes mellitus, Monckeberg’s sclerosis and cardiovascular disease

Chauhan, Abha; Sandal, Rajeev; Jandial, Aditya; Mishra, Kundan

doi:10.1136/bcr-2021-245778

Cited by 5 publications

(10 citation statements)

References 5 publications

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“…An array of radiographic terms has been employed for characterizing MMC, namely “railroad track,” “rail tracking,” “pipe stem,” “pipeline,” “tram line,” or “tram track” patterns. MMC of the head and neck has involved the facial, lingual, carotid, infraorbital, temporal, and maxillary arteries, and typically found on panoramic radiographic examinations and cone beam computed tomography (CBCT) scans, and less frequently on intraoral periapical and bitewing images 1–14 . Affected patients may have unilateral or bilateral presentations 13…”

Section: Discussionmentioning

confidence: 99%

“…Despite the calcification of the arterial wall, most affected patients with MMC of the oral and maxillofacial vasculature remain asymptomatic and do not experience significant regional hypoperfusion 1–5,7–14 . In contrast, atherosclerosis may be associated with hypercholesterolemia, arterial stenosis, diabetes, and ischemic disease, particularly affecting the coronary vasculature 17,18 .…”

Section: Discussionmentioning

confidence: 99%

“…In extreme cases, MMC of the extremities has led to severe ischemia, requiring multiple amputations 21 . Nevertheless, the radiologic discovery of MMC may serve as an indicator of diabetes, hypertension, atherosclerotic cardiovascular disease, renal disease, and hyperparathyroidism 1–5,7–14 …”

Section: Discussionmentioning

confidence: 99%

“…Mönckeberg medial calcinosis (MMC), also known as Mönckeberg sclerosis or Mönckeberg arteriosclerosis, is associated with arterial pathophysiologic alterations of the arteries of the lower extremities, heart and other viscera, whereas head and neck involvement is infrequent 1 . Affected arteries may appear radiographically as tortuous or linear radiopaque structures, typically discovered in patients older than 50 years of age 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Affected arteries may appear radiographically as tortuous or linear radiopaque structures, typically discovered in patients older than 50 years of age 2 . MMC has been attributed to calcification of the tunica media of small and medium‐sized arteries and correlated with end‐stage renal failure, diabetes mellitus, hyperparathyroidism, excessive vitamin D levels, systemic lupus erythematosus, possible regional hypoperfusion, and advanced age 1,3–6 . The majority of cases of MMC are incidental radiographic findings, with affected patients usually remaining asymptomatic and without luminal occlusion 1–5,7–14 …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Occult Mönckeberg medial calcinosis of the facial and infraorbital arteries in an elderly edentulous patient

Brooks

Shin²,

Price

2022

Special Care in Dentistry

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Mönckeberg medial calcinosis (MMC) is a potentially serious vasculopathy involving calcification of the arterial tunica media of the extremities, heart, and other viscera. There are a limited number of cases reported in the dental literature, usually associated with the facial artery. Although MMC is often discerned as an occult radiologic finding in middle-aged adults, its presence may serve as a harbinger for end-stage renal disease, diabetes, other pathologic processes, and possible regional hypoperfusion. The objective of this report is to feature an elderly patient with MMC of the facial and infraorbital arteries. In addition, a brief review of published cases of MMC and its differential diagnosis have been provided. It is recommended that affected patients be referred for a comprehensive medical assessment. Timely discovery of calcified arteries may improve patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Occult Mönckeberg medial calcinosis of the facial and infraorbital arteries in an elderly edentulous patient

Brooks

Shin²,

Price

2022

Special Care in Dentistry

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Cognitive status and its risk factors in patients with hypertension and diabetes in a low‐income rural area of China: A cross‐sectional study

Guo,

Liang,

Ren

et al. 2023

Int J Geriat Psychiatry

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ObjectivesThe proportion of older people with dementia in China is gradually increasing with the increase in the aging population over recent years. Hypertension and diabetes are common non‐communicable diseases among rural populations in China. However, it remains unclear whether these conditions affect the occurrence and development of cognitive impairment as there is limited research on cognitive status and its risk factors among residents of rural areas.MethodsA multi‐stage stratified cluster random sampling method was used to select 5400 participants from rural permanent residents. A self‐designed structured questionnaire was used to investigate demographic data of the participants. Cognitive function was assessed using the Montreal Cognitive Function Assessment Scale (MoCA). The results were analyzed using chi‐square test, ANOVA and multiple linear regression analysis.ResultsA total of 5028 participants returned the survey, giving a response rate of 93.1%. Higher education (odds ratio (OR) = 3.2, 95% confidence interval (CI) 2.87–3.54, p < 0.001), higher income (OR = 1.61, 95% CI 1.16–2.07, p < 0.001), and dietary control (OR = 0.66, 95%CI 0.34–0.98, p < 0.001) were protective factors. A visual representation of the relationship between annual income and MoCA score showed an inverted U‐curve, the group with an annual income of 6000–7999 RMB had a maximum OR of 1.93 (95%CI 0.12–2.74, p < 0.001). While difficulty in maintaining sleep were risk factors for cognitive impairment (OR = −2.28, 95% CI–4.18–0.39, p = 0.018).ConclusionsParticipants with middle incomes had better cognitive status than those with the highest incomes. Higher education, proper diet control and good sleep are beneficial to the cognitive status of residents in rural areas.

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Mönckeberg's medial calcific sclerosis in diabetic and non‐diabetic foot infections

Suludere

Killeen

Crisologo

et al. 2023

Wound Repair Regeneration

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The aim of this study was to evaluate the prevalence and extent of lower extremity Mönckeberg's Medial Calcific Sclerosis (MMCS) in patients with and without diabetes in patients admitted to the hospital for foot infections. This study retrospectively reviewed 446 patients admitted to the hospital with a moderate or severe foot infection. We defined diabetes based on ADA criteria and reviewed electronic medical records for demographics, medical history and physical examination data. Anteriorposterior and lateral foot radiographs were examined to identify the presence and extent of vascular calcification. We categorised MMCS based on anatomical location: ankle joint to the navicular-cuneiform joint, Lis Franc joint to metatarsophalangeal joints and distal to the metatarsophalangeal joints. The prevalence of MMCS was 40.6%. The anatomic extent of MMCS was 19.3% in the toes, 34.3% in the metatarsals and 40.6% in the hindfoot/ankle. Calcification was not common solely in the dorsalis pedis artery (DP) (3.8%) or solely in the posterior tibial artery (PT) (7.0%). Usually, both DP and PT arteries were affected by MMCS (29.8%). The prevalence of MMCS was higher in people with diabetes (in hindfoot and ankle [50.1% vs. 9.9%, p ≤ 0.01]; metatarsals [42.6% vs. 5.9%, p ≤ 0.01]; and toes [23.8% vs. 4.0%, p ≤ 0.01]). People with diabetes were 8.9 (CI: 4.5-17.8) times more likely to have MMCS than those without diabetes. This is a group that often has poor perfusion and needs vascular assessment.The high prevalence of MMCS raises questions about the reliability of the conventional segmental arterial Doppler studies to diagnose PAD.

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Diabetes mellitus, Monckeberg’s sclerosis and cardiovascular disease

Cited by 5 publications

References 5 publications

Occult Mönckeberg medial calcinosis of the facial and infraorbital arteries in an elderly edentulous patient

Occult Mönckeberg medial calcinosis of the facial and infraorbital arteries in an elderly edentulous patient

Cognitive status and its risk factors in patients with hypertension and diabetes in a low‐income rural area of China: A cross‐sectional study

Mönckeberg's medial calcific sclerosis in diabetic and non‐diabetic foot infections

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