Diabetes mellitus: Possible risk and promoting factors of cholangiocarcinoma

Saengboonmee, Charupong; Seubwai, Wunchana; Wongkham, Chaisiri; Wongkham, Sopit

doi:10.1016/j.canep.2015.04.002

Cited by 36 publications

(27 citation statements)

References 39 publications

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“…Moreover, regulatory T cells are associated with faster tumor growth and poor prognosis of cancer (Nomura and Sakaguchi, 2005). A recent report indicates that dysmetabolism of glucose, perhaps in the setting of diabetes (Saengboonmee et al, 2015), and activities of dicarbonyl stress may also be implicated (Saltykova et al, 2016). …”

Section: Liver Fluke Infections and Cholangiocarcinomamentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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Cancer may be induced by many environmental and physiological conditions. Infections with viruses, bacteria and parasites have been recognized for years to be associated with human carcinogenicity. Here we review current concepts of carcinogenicity and its associations with parasitic infections. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic while the protozoan Trypanosoma cruzi, the causing agent of Chagas disease, has a dual role in the development of cancer, including both carcinogenic and anticancer properties. Although malaria per se does not appear to be causative in carcinogenesis, it is strongly associated with the occurrence of endemic Burkitt lymphoma in areas holoendemic for malaria. The initiation of Plasmodium falciparum related endemic Burkitt lymphoma requires additional transforming events induced by the Epstein-Barr virus. Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity.

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Section: Liver Fluke Infections and Cholangiocarcinomamentioning

confidence: 99%

Parasite Infection, Carcinogenesis and Human Malignancy

et al. 2017

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“…CCA is slow growing but highly metastatic, therefore, most of the patients present in an advanced stage with poor prognosis910. The positive linkage between diabetes mellitus and CCA in Northeast Thailand was suggested by mortality surveys11. Recently, the effects of high glucose in promoting cell proliferation, adhesion, migration, and invasion were demonstrated in CCA cell lines.…”

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confidence: 99%

High glucose levels boost the aggressiveness of highly metastatic cholangiocarcinoma cells via O-GlcNAcylation

Phoomak

Vaeteewoottacharn

Silsirivanit

et al. 2017

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Increased glucose utilization is a feature of cancer cells to support cell survival, proliferation, and metastasis. An association between diabetes mellitus and cancer progression was previously demonstrated in cancers including cholangiocarcinoma (CCA). This study was aimed to determine the effects of high glucose on protein O-GlcNAcylation and metastatic potentials of CCA cells. Two pairs each of the parental low metastatic and highly metastatic CCA sublines were cultured in normal (5.6 mM) or high (25 mM) glucose media. The migration and invasion abilities were determined and underlying mechanisms were explored. Results revealed that high glucose promoted migration and invasion of CCA cells that were more pronounced in the highly metastatic sublines. Concomitantly, high glucose increased global O-GlcNAcylated proteins, the expressions of vimentin, hexokinase, glucosamine-fructose-6-phosphate amidotransferase (GFAT) and O-GlcNAc transferase of CCA cells. The glucose level that promoted migration/invasion was shown to be potentiated by the induction of GFAT, O-GlcNAcylation and an increase of O-GlcNAcylated vimentin and vimentin expression. Treatment with a GFAT inhibitor reduced global O-GlcNAcylated proteins, vimentin expression, and alleviated cell migration. Altogether, these results suggested the role of high glucose enhanced CCA metastasis via modulation of O-GlcNAcylation, through the expressions of GFAT and vimentin.

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“…Repositioning a drug that is already clinically used provides a way to shortcut the research and time required, and costs much less (5). Diabetes mellitus (DM) has been reported to be associated with risk and prognosis of many cancer types, including CCA (6,7). The molecules that bridge DM and cancer have been shown to be insulin and a high blood glucose level (8)(9)(10).…”

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confidence: 99%