Diabetes mellitus susceptibility with varied diseased phenotypes and its comparison with phenome interactome networks

Abstract

An emerging area of interest in understanding disease phenotypes is systems genomics. Complex diseases such as diabetes have played an important role towards understanding the susceptible genes and mutations. A wide number of methods have been employed and strategies such as polygenic risk score and allele frequencies have been useful, but understanding the candidate genes harboring those mutations is an unmet goal. In this perspective, using systems genomic approaches, we highlight the application of phenome-interactome networks in diabetes and provide deep insights. LINC01128, which we previously described as candidate for diabetes, is shown as an example to discuss the approach.

Upregulated lncRNA LINC01128 in colorectal cancer accelerates cell growth and predicts malignant prognosis through sponging miR-363-3p

“…LINC01128 was found to affect the activity of human chorionic trophoblast cells via targeting miR-16 (Zhao et al 2021 ). In addition, LINC01128 was reported in pancreatic adenocarcinoma, breast cancer, and diabetes (Deng et al 2022 ; Rout et al 2022 ; Wang et al 2021 ). This study showed that LINC01128 was overexpressed in CRC, and this upregulation trend was also closely related to some of the clinicopathological characteristics of the included patients, such as TNM stage and lymph node metastasis.…”

“…For example, Chen et al confirmed the potential of elevated expression of circNCOA3 in CRC drug resistance, patient prognosis and treatment in the latest report (Chen et al 2024 ). LncRNA LINC01128 (LINC01128) was believed to be associated with human diseases, which was abnormally expressed in a variety of tumors (Li et al 2020 ; Rout et al 2022 ; Yan et al 2021 ). Moreover, LINC01128 was mentioned as a possible association with cancer staging (Zhou et al 2020 ).…”

Knockdown of LINC01128 Downregulates FUT8 to Inhibit OxLDL-Induced Vascular Smooth Muscle Cell Apoptosis in Atherosclerosis

“…Previous studies have shown that individuals with diabetes are prone to AS plaques with calcification, suggesting that diabetes may facilitate the progression of severe AS lesions [29]. LINC01128 has been identified as a biomarker for the diagnosis and prognosis of diabetes and is considered a key lncRNA in AS [14,30]. It is enriched in the p53 signaling pathway, whose activation induces the apoptosis of plaque VSMCs [8,31].…”