Diabetes mellitus type 2 as an underlying, comorbid or consequent state of mental disorders

Borovcanin, M.; Vesić, Katarina; Petrovic, Ivica; Jovanović, Ivan; Mijailović, Nataša R.

doi:10.4239/wjd.v14.i5.481

Cited by 10 publications

(7 citation statements)

References 135 publications

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“…Depression is a common issue among individuals with diabetes, affecting their mental health and complicating diabetes management 12 , 13 , 19 . Diabetes distress, related to the emotional burden of managing the condition, correlates strongly with depression, affecting patient well-being and adherence to treatment 20 – 25 .…”

Section: Introductionmentioning

confidence: 99%

Psychological resilience mediates the relationship between diabetes distress and depression among persons with diabetes in a multi-group analysis

Wojujutari,

Idemudia,

Ugwu

2024

Sci Rep

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The aim to examine the link between diabetes distress and depression in individuals with diabetes, assess the mediating role of psychological resilience in this relationship, and analyses if these relationships differ between Type 1 and Type 2 diabetes. The study utilized a cross-sectional design. A total of 181 (age 33–72 years, mean = 54.76 years, and SD = 9.05 years) individuals diagnosed with diabetes who were receiving treatment from State Specialist Hospitals in Okitipupa were selected for the study using the convenient sampling technique. The data were analysed using Pearson Multiple correlation and multi-group mediation analysis. The analyses were carried out with Smartpls and IBM/SPSS Version 28.0. The results revealed a significant positive correlation between diabetes distress and depression (r = .80, p < .05), suggesting that higher levels of diabetes distress were associated with increased depression scores. Additionally, psychological resilience partially mediated the relationship between diabetes distress and depression (b = − 0.10, p < .05), signifying that resilience played a crucial role in mitigating the impact of diabetes distress on depression. Furthermore, a multi-group analysis was conducted to explore potential differences between Type 1 and Type 2 diabetes subgroups. The relationship between diabetes distress and depression was found to be more pronounced in the Type 1 subgroup (difference = 0.345, p < .05), while the relationship between psychological resilience and depression was negatively stronger in the Type 2 subgroup (difference = − 0.404, p < .05) compared to the Type 1 subgroup. There is an intricate linkage between diabetes distress, resilience, and depression, emphasizing the differential roles of resilience in Type 1 and Type 2 diabetes. The insights gleaned from this study underscore the importance of considering the type of diabetes when designing interventions and support mechanisms for individuals with diabetes who are also suffering from depression. By advancing our understanding of these dynamics, we can strive for more effective and personalized approaches to improve the overall well-being of those living with diabetes.

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Section: Introductionmentioning

confidence: 99%

Psychological resilience mediates the relationship between diabetes distress and depression among persons with diabetes in a multi-group analysis

Wojujutari,

Idemudia,

Ugwu

2024

Sci Rep

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“…Yet, the exact mechanisms underlying their association remain unclear, but are likely to include both environmental and genetic risk factors. First, physical inactivity, sedentary behaviors, poor dietary habits, and obesity are known to be associated with both T2DM and psychiatric disorders (Borovcanin, Vesic, Petrovic, Jovanovic, & Mijailovic, 2023). Second, several biological mechanisms have been suggested to link T2DM and psychiatric disorders, such as alterations in brain insulin signaling, inflammatory and immune disturbances, oxidative stress, and hypothalamic-pituitary-adrenal axis dysregulation (Borovcanin et al, 2023;Fanelli et al, 2022;PRIME, 2020PRIME, -2024.…”

Section: Introductionmentioning

confidence: 99%

“…First, physical inactivity, sedentary behaviors, poor dietary habits, and obesity are known to be associated with both T2DM and psychiatric disorders (Borovcanin, Vesic, Petrovic, Jovanovic, & Mijailovic, 2023). Second, several biological mechanisms have been suggested to link T2DM and psychiatric disorders, such as alterations in brain insulin signaling, inflammatory and immune disturbances, oxidative stress, and hypothalamic-pituitary-adrenal axis dysregulation (Borovcanin et al, 2023;Fanelli et al, 2022;PRIME, 2020PRIME, -2024. From an epidemiological perspective, the bi-directional associations between the conditions suggest that these conditions may to a substantial degree share familial risk factors (referring to any genetic and environmental factors shared among family members).…”

Section: Introductionmentioning

confidence: 99%

Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study

Wimberley,

Brikell,

Astrup

et al. 2024

Psychol. Med.

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Background Psychiatric disorders and type 2 diabetes mellitus (T2DM) are heritable, polygenic, and often comorbid conditions, yet knowledge about their potential shared familial risk is lacking. We used family designs and T2DM polygenic risk score (T2DM-PRS) to investigate the genetic associations between psychiatric disorders and T2DM. Methods We linked 659 906 individuals born in Denmark 1990–2000 to their parents, grandparents, and aunts/uncles using population-based registers. We compared rates of T2DM in relatives of children with and without a diagnosis of any or one of 11 specific psychiatric disorders, including neuropsychiatric and neurodevelopmental disorders, using Cox regression. In a genotyped sample (iPSYCH2015) of individuals born 1981–2008 (n = 134 403), we used logistic regression to estimate associations between a T2DM-PRS and these psychiatric disorders. Results Among 5 235 300 relative pairs, relatives of individuals with a psychiatric disorder had an increased risk for T2DM with stronger associations for closer relatives (parents:hazard ratio = 1.38, 95% confidence interval 1.35–1.42; grandparents: 1.14, 1.13–1.15; and aunts/uncles: 1.19, 1.16–1.22). In the genetic sample, one standard deviation increase in T2DM-PRS was associated with an increased risk for any psychiatric disorder (odds ratio = 1.11, 1.08–1.14). Both familial T2DM and T2DM-PRS were significantly associated with seven of 11 psychiatric disorders, most strongly with attention-deficit/hyperactivity disorder and conduct disorder, and inversely with anorexia nervosa. Conclusions Our findings of familial co-aggregation and higher T2DM polygenic liability associated with psychiatric disorders point toward shared familial risk. This suggests that part of the comorbidity is explained by shared familial risks. The underlying mechanisms still remain largely unknown and the contributions of genetics and environment need further investigation.

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“…Bu rakamlar, diyabetin küresel bir sağlık sorunu olduğunu ve önlem alınmadığı takdirde daha fazla insanın hayatını tehdit edeceğini göstermektedir. Bu durum, diyabetin nedenlerinin ve etkilerinin daha iyi anlaşılması gerektiğini ortaya koymaktadır (8,9). Beslenme alışkanlıkları, bireyin yaşam boyu edindiği kültürel, sosyal, ekonomik ve psikolojik etmenlerden etkilenmektedir (10).…”

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“…Sağlıksız beslenme alışkanlıkları, kan şekeri düzenini ve regülasyonunu bozarak diyabet gelişimine katkıda bulunabilir (17,22,23). Bu bağlamda, sağlıklı bir yaşam için psikopatolojik semptomların tanınması ve tedavi edilmesi, aynı zamanda dengeli bir beslenme programının uygulanması gerekmektedir (8,19,24). Diyabet, sağlıklı yaşam biçimi davranışları ile önlenebilen bir hastalık olduğu için, riskin genç yaşlarda belirlenmesi, daha fazla araştırma yapılması, gençlerin risk durumlarını anlamaları ve sağlıklı yaşam biçimi davranışlarına yönelmeleri açısından önemlidir (19,25).…”

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The Relationship Between Nutritional Habits and Psychopathological Symptoms and the Risk of Type 2 Diabetes in University Students

KUL,

ÇARIKÇI,

AKTAŞ

et al. 2023

Turk J Diab Obes

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Amaç: Üniversite öğrencilerinin sağlıklı yaşam biçimi davranışlarını göstermeleri ve diyabet riski konusunda farkındalık kazanmaları önemlidir. Araştırma üniversite öğrencilerinin diyabet risklerinin belirlenerek, beslenme alışkanlıkları ve psikopatolojik semptomlarının tip 2 diyabet riski ile ilişkisini değerlendirmek amacıyla tanımlayıcı ve kesitsel araştırma tipinde gerçekleştirilmiştir. Gereç ve Yöntemler: Araştırma 10 Mart-10 Haziran 2023 tarihleri arasında bir vakıf üniversitesinde öğrenim gören 869 öğrenci ile gerçekleştirilmiştir. Veriler; Tanıtıcı Bilgi Formu, Tip 2 Diyabet Risk Değerlendirme Formu-FINDRISK, Beslenme Alışkanlıkları İndeksi ve DUKE Sağlık Profili Ölçeği ile toplanmıştır. Verilerin değerlendirilmesinde yüzde sayı dağılımı, Kolmogorov Smirnov testi, bağımsız örneklem t testi, One Way ANOVA ve Pearson korelasyon analizi kullanılmıştır. Bulgular: Katılımcıların %81,4’ü (n=707) kadın ve %88,1’i (n=766) 18-24 yaş arasındadır. Katılımcıların Tip 2 Diyabet Risk Skoru puan ortalaması 6,53±3,71; Beslenme Alışkanlıkları İndeksi puan ortalaması 11,08±3,55; DUKE Sağlık Profili fonksiyonel alt boyut puan ortalaması 323,85±87,51 ve disfonksiyonel alt boyut puan ortalaması 344,37±86,36 olarak belirlenmiştir. Katılımcıların %11,3’ünün orta ve yüksek diyabet risk düzeyine sahip olduğu; ekonomik durumunun kötü olduğunu bildiren, kronik hastalığı olan, hastalığı nedeniyle diyet tedavisi uygulayan ve yaşı≥46 yıl olan; beden kütle indeksine göre obez ve bel çevresi normalin üzerinde olan katılımcıların diyabet risk puan ortalamalarının daha yüksek olduğu saptanmıştır. Katılımcıların Tip 2 Diyabet Risk Skoru puanı ile Beslenme Alışkanlıkları İndeksi arasında pozitif yönde ve zayıf derecede (p=0,005, r=0,122); Tip 2 Diyabet Risk Skoru puanı ile DUKE Sağlık Profili Ölçeği alt boyutları arasında ise negatif yönde zayıf derecede anlamlı bir ilişkinin bulunduğu belirlenmiştir (p

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Diabetes mellitus type 2 as an underlying, comorbid or consequent state of mental disorders

Cited by 10 publications

References 135 publications

Psychological resilience mediates the relationship between diabetes distress and depression among persons with diabetes in a multi-group analysis

Psychological resilience mediates the relationship between diabetes distress and depression among persons with diabetes in a multi-group analysis

Shared familial risk for type 2 diabetes mellitus and psychiatric disorders: a nationwide multigenerational genetics study

The Relationship Between Nutritional Habits and Psychopathological Symptoms and the Risk of Type 2 Diabetes in University Students

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