Diabetes or endocrinopathy admitted in the COVID‐19 ward

Clotman, Katrien; Twickler, Marcel Th B

doi:10.1111/eci.13262

Cited by 16 publications

(13 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease caused by SARS‐CoV‐2, named COVID‐19, has caused over 550 000 deaths and infected over 19 000 000 people worldwide (by Aug 7, 2020 1 ). Although individuals from all ages can be infected, the clinical prognosis is worse for patients harbouring one or more risk factors, including age, obesity, hypertension, diabetes, respiratory and/or cardiovascular disease, and cancer, or autoimmune diseases, among others 2‐4 …”

Section: Figurementioning

confidence: 99%

Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection

Coelho

Oliveira

2020

Eur J Clin Investigation

View full text Add to dashboard Cite

Since late 2019, a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral outbreak has spread all over the world. The disease caused by SARS-CoV-2, named COVID-19, has caused over 550 000 deaths and infected over 19 000 000 people worldwide (by Aug 7, 2020 1). Although individuals from all ages can be infected, the clinical prognosis is worse for patients harbouring one or more risk factors, including age, obesity, hypertension, diabetes, respiratory and/or cardiovascular disease, and cancer, or autoimmune diseases, among others. 2-4 Current models indicate that the surface unit (S1) of the spike (S) protein of SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2) as the entry receptor in host cells. SARS-CoV-2 uses then the host serine protease TMPRSS2 for S priming, to which fusion of viral and cellular membranes follows, allowing for viral entry into the cell and fast replication. 5,6 Although more information on the mechanisms of SARS-CoV-2 entry in different cell types is available on a daily basis, intra-cellular modulation of viral replication is still under-studied. Important intra-cellular components for viral replication include mitochondria, which not only are involved in the production of cellular energy, regulation of redox and ionic fluxes, intermediate metabolism (including production of nucleotides) and regulation of cell death 7,8 but also have a critical role for the regulation of host innate immunity. 9,10 Interestingly, data obtained with SARS-CoV, the aetiologic agent of the 2002-2003 SARS outbreak, showed that SARS-CoV-encoded open reading frame-9b (ORF-9b) peptide localizes to mitochondria in A549 and HEK 293 cells and causes mitochondrial elongation, 11 by leading to ubiquitination and proteasomal degradation of dynamin-like protein 1, a mitochondrial protein involved in mitochondrial fusion events. 12 Furthermore, the same paper demonstrated that ORF-9b increased autophagy through ATG-5-mediated effects. Importantly, the viral peptide led to evasion of the host innate immunity by targeting the mitochondrial-associated adaptor molecule MAVS (also known as ISP-1/VISA/ Cardiff) signalosome by usurping PCBP2 and the HECT domain E3 ligase AIP4. This chain of events leads to the degradation of MAVS, TRAF3 and TRAF 6, severely limiting the

show abstract

Section: Figurementioning

confidence: 99%

Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection

Coelho

Oliveira

2020

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…However, there are no available data regarding the incidence of cases with COVID-19 among patients with T2D. Curiously, this was completely the opposite of the situation among adults with diabetes, either T2D or T1D, who have been identified as one of the highest risk groups with an increased rate of hospitalisation (80). The risk of death due to COVID-19 in adults was about three times higher than the rest of the population as a whole (81).…”

Section: Effects Of the Covid-19 Pandemic On Patients With Type 2 Diabetes Among Children And Young Adultsmentioning

confidence: 99%

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Elmajnoun

Faris

Uday³

et al. 2021

Front. Nutr.

View full text Add to dashboard Cite

Background: The world is still struggling to control the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The level of uncertainty regarding the virus is still significantly high. The virus behaves differently in children and young adults. Most children and adolescents are either asymptomatic or have mild symptoms. They generally have a very good prognosis. However, it is not well-known whether children and young adults with type 2 diabetes are at risk of getting a severe infection of COVID-19. Many Muslim children with type 2 diabetes have been performing dawn to dusk fasting during the month of Ramadan, before and during the COVID-19 pandemic, and the impact of this on their health has not been well investigated. Previous studies in adults have suggested that intermittent fasting may be beneficial in different ways including reversal of type 2 diabetes and prevention of COVID-19 infection.Objective: The primary aim of this narrative review is to summarise the impacts of the COVID-19 pandemic on children and young adults with type 2 diabetes, and to identify the knowledge gaps in the literature. It also explores the potential of intermittent fasting in reversing the pathogenesis of diabetes and highlighting how this approach could prevent these patients from developing chronic complications.Methods: This narrative review has been produced by examining several databases, including Google Scholar, Research Gate, PubMed, Cochrane Library, MEDLINE (EBSCO), and Web of Science. The most common search terms used were “COVID-19 AND Children”, “SARS-CoV-2 AND/OR Children”, “COVID-19 AND Diabetes” “COVID-19 Epidemiology”, “COVID-19 AND Ramadan fasting”, “COVID-19 and Intermittent fasting.” All the resources used are either peer-reviewed articles/reports and/or official websites of various media, governmental and educational organisations.Results: Having reviewed the currently limited evidence, it has been found that the incidence of COVID-19 among children with type 2 diabetes seems to be not much different from children without diabetes. However, these patients are still vulnerable to any infection. Several studies have reported that prevention programmes such as intermittent fasting are effective to protect these groups of patients from developing any complications. Moreover, observing Ramadan fasting as a type of intermittent fasting could be beneficial for some children with established diabetes, prediabetes and people at risk.Conclusion: Children and young adults with type 2 diabetes are not at risk of severe COVID-19 infection as the case in adults with diabetes. More research is needed to identify the impact of COVID-19 and to investigate the efficacy and safety of intermittent fasting, including Ramadan fasting, among these age groups. Implementing these cost-effective programmes may have a great impact in minimising the incidence of diabetes. Moreover, this could be effective particularly at prediabetes stage by preventing these people from going onto develop type 2 diabetes and taking medications for the rest of their life and protecting people from complications linked to disease and infection.

show abstract

“…Based on the information that we have access to, a panel of specialists recommend harmless and firm controller of blood sugar and blood pressure levels [10]. Another challenge will be the reviving of society with the existence of virus clusters and continuous low viremia in the general population [11].…”

Section: Psychosocial Issuesmentioning

confidence: 99%

An Association between Diabetes and COVID-19 Patients: A Brief Overview

Parmita

Ghodmare

2021

JPRI

View full text Add to dashboard Cite

Coronavirus disease, a pandemic (COVID19), an illness caused by the severe acute respiratory syndrome Coronavirus 2 (SARSCoV2), is triggering significant illness and death. The current coronavirus disease SARSCoV2 2019 (COVID19) pandemic is a certain challenge for patients with diabetes. Advanced phase and the occurrence of diabetes mellitus, high blood pressure, and obesity rise the threat of hospitalization and contribute to the sternness and death of patients with COVID19. Furthermore, it further exacerbate the clinical consequences for those patients with diabetes who often suffer from comorbidities. In infectious diseases blood sugar control is often suboptimal, and Insulin therapy and Anti-diabetic drugs must be adjusted consequently. On the other hand, diabetic patient’s accessibility to the outpatient clinics is limited during the current season in order to advise on unconventional treatment options, in particular to the implementation of new telemedical strategies. Therefore, the COVID-19 disaster should be used as an opportunity to take a remarkable step in the care of patients with diabetes. COVID19 patients suffering from diabetes are related with a two bend upsurge in death and cruelty of COVID19 matched to people who don’t have diabetes additionally, data suggests that high blood pressure, diabetes and cardiovascular disease are peril factors important for progression and unfavourable of COVID 19 patients. It was a critical obstacle to conduct an examination that should contain numerous intriguing features, like a progressive age, addicted to smoking, and obesity that could possibly alter the deduction depending on the limited number of victims.

show abstract

Diabetes or endocrinopathy admitted in the COVID‐19 ward

Cited by 16 publications

References 22 publications

Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection

Dihydroorotate dehydrogenase inhibitors in SARS‐CoV‐2 infection

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

An Association between Diabetes and COVID-19 Patients: A Brief Overview

Contact Info

Product

Resources

About