Diabetes, prediabetes and cancer mortality

Abstract

Aims/hypothesis We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. Methods Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. Results Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant Electronic supplementary material The online version of this article

Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death

“…Furthermore, we studied several factors proposed to mediate associations of diabetes and cancer. 31 The generalizability of our findings to populations in economically developed Western countries is supported by broadly consistent results across 97 prospective cohorts in 25 countries. Even though the 6% overall prevalence of diabetes in our study was somewhat lower than the prevalence currently reported for some Western populations, this difference would not have influenced hazard ratios.…”

Diabetes Mellitus Is Associated with Increased Mortality in Patients Receiving Curative Therapy for Hepatocellular Carcinoma

“…Epidemiology studies revealed that DM increased the incidence of HCC among individuals with chronic hepatitis B or C virus infection [6 -12]. In addition, patients with DM or prediabetes had higher liver cancer mortality rates [13]. However, the impact of DM on the prognosis of patients with HCC remains controversial.…”

Fasting proinsulin levels are significantly associated with 20 year cancer mortality rates. The Hoorn Study

“…Individuals with impaired glucose metabolism (IGM) or type 2 diabetes might have an increased risk of cancer and cancerrelated mortality [1][2][3][4][5][6][7]. Insulin resistance, hyperglycaemia, high levels of insulin, and production of IGF-I and IGF-II have been suggested to induce tumour cell growth, thereby possibly providing a mechanistic link between glucose metabolism and cancer [1,3,6,8].…”

“…None of the studies [1][2][3][4][5][6][7] that reported on the association between glucose metabolism and cancer took proinsulin into account. In the light of recent evidence [14] for the potential link between proinsulin and cancer, proinsulin could explain part of the overall risk of developing cancer.…”