Diabetes-Related Autoantibodies and Gestational Diabetes

Leiva, Alberto de; Mauricio, Dı́dac; Corcoy, Rosa

doi:10.2337/dc07-s204

Cited by 40 publications

(28 citation statements)

References 76 publications

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“…Anti-ZnT-8 as autoantibody is comparable to the already identified autoantibodies characteristic for type 1 diabetes like antibodies to insulin (IAA), the 65-kDa form of glutamate decarboxylase (GADA), protein tyrosine phosphatase IA2 (IA2A) and islet cytoplasmic autoantibodies (ICA) [54,231]. Anti-ZnT-8 is present in 26% of patients who were previously classified as autoantibody negative after being tested for the four autoantibodies enumerated above.…”

Section: The Role Of Mt and The Zinc Transporter Znt-8 In Diabetes Mementioning

confidence: 92%

Zinc and diabetes — clinical links and molecular mechanisms

Jansen

Karges

Rink

2009

The Journal of Nutritional Biochemistry

392

273

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Section: The Role Of Mt and The Zinc Transporter Znt-8 In Diabetes Mementioning

confidence: 92%

Zinc and diabetes — clinical links and molecular mechanisms

Jansen

Karges

Rink

2009

The Journal of Nutritional Biochemistry

392

273

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“…Subjects found to have significant titers of antiinsulin antibodies or antibodies to islet cell antigens at diagnosis of GDM are at high risk to progress to overt DM, subsequently having phenotypic features suggesting type 1 DM. 6 The proportion of subjects with GDM that have such antibodies is highest among northern European white populations.…”

Section: Future Risk Of Dmmentioning

confidence: 99%

Long-term Outcomes in Mothers Diagnosed With Gestational Diabetes Mellitus and Their Offspring

Metzger

2007

Clinical Obstetrics &Amp; Gynecology

261

171

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Mothers with gestational diabetes mellitus (GDM) are at high lifetime risk of developing type 2 diabetes mellitus. The magnitude of risk for cardiovascular disease after GDM is less well established. Recently, intervention trials using lifestyle modification or medications used to treat type 2 DM have successfully prevented/delayed development of DM in women after GDM. Offspring of mothers with GDM are at risk for development of obesity and abnormal glucose metabolism during childhood, adolescence, and adulthood. Factors responsible for these risks are not fully understood. Having fetal hyperinsulinism is a risk factor for development of both obesity and abnormal glucose metabolism, and might be implicated in pathophysiology. It remains to be established whether the long-term effects of exposure to diabetes mellitus during intrauterine development can be prevented.

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“…The prevalence of auto-immune markers of type 1 diabetes (T1D) is between 0.98 and 14.7% in women with GDM. It predicts later development of T1D in these women but not necessarily (47). In some studies (48,49), positive islet cell autoantibodies were not predictive of future diabetes development.…”

Section: Type 1 Diabetesmentioning

confidence: 99%

ENDOCRINOLOGY OF PREGNANCY: Gestational diabetes mellitus: definition, aetiological and clinical aspects

Baz

Riveline

Gautier

2016

European Journal of Endocrinology

217

160

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Gestational diabetes (GDM) is defined as a glucose intolerance resulting in hyperglycaemia of variable severity with onset during pregnancy. This review aims to revisit the pathogenesis and aetiology of GDM in order to better understand its clinical presentation and outcomes. During normal pregnancy, insulin sensitivity declines with advancing gestation. These modifications are due to placental factors, progesterone and estrogen. In a physiological situation, a compensatory increase in insulin secretion maintains a normal glucose homeostasis. GDM occurs if pancreatic b-cells are unable to face the increased insulin demand during pregnancy. GDM is most commonly a forerunner of type 2 diabetes (T2D) -the most prevalent form of diabetes. These women share similar characteristics with predisposed subjects to T2D: insulin resistance before and after pregnancy, and carry more T2D risk alleles. Auto-immune and monogenic diabetes are more rare aetiologies of GDM. Adverse pregnancy outcomes of GDM are mainly related to macrosomia caused by fetal hyperinsulinism in response to high glucose levels coming from maternal hyperglycaemia. Screening recommendations and diagnosis criteria of GDM have been recently updated. High risk patients should be screened as early as possible using fasting plasma glucose, and if normal, at 24-28 weeks of gestation using 75 g oral glucose tolerance test. The treatment of GDM is based on education with trained nurses and dieticians, and if necessary insulin therapy.

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Diabetes-Related Autoantibodies and Gestational Diabetes

Cited by 40 publications

References 76 publications

Zinc and diabetes — clinical links and molecular mechanisms

Zinc and diabetes — clinical links and molecular mechanisms

Long-term Outcomes in Mothers Diagnosed With Gestational Diabetes Mellitus and Their Offspring

ENDOCRINOLOGY OF PREGNANCY: Gestational diabetes mellitus: definition, aetiological and clinical aspects

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