Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Joubert, Michaël; Manrique, Alain; Cariou, Bertrand; Prieur, Xavier

doi:10.1016/j.diabet.2018.07.003

Cited by 66 publications

(51 citation statements)

References 134 publications

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“…Impaired eNOS activity and hypercoagulable states associated with atherosclerosis and vascular dysfunction are observed in the vascular system of diabetes and associated MetS [177,178]. In addition, altered glucose metabolism and glucose overload in cardiomyocytes promote oxidative stress and accumulation of advanced glycation end-products, subsequently causing apoptosis and cardiac dysfunction [179,180]. Furthermore, pro-and antiinflammatory mediators released from perivascular adipose tissue are involved in the development of atherosclerosis [181], suggesting that adipocytes may play a key role in diabetes-associated cardiovascular dysfunctions.…”

Section: Vascular Protectionmentioning

confidence: 99%

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Vascular Protectionmentioning

confidence: 99%

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Shinjyo

Parkinson

Bell

et al. 2020

Journal of Integrative Medicine

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“…T2DM-associated hyperglycemia, chronic inflammation, and oxidative stress are linked with mitochondrial dysfunction and the development of DCM [70]. Hyperglycemia induces oxidative stress by enhancing the production of oxygen free radicals and facilitating cardiomyocyte apoptosis [24,71]. The excess oxygen free radicals interact with lipids, proteins, and DNA and lead to pathological changes [24].…”

Section: Oxidative Stress In Cardiomyocytesmentioning

confidence: 99%

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Seo

Jang

et al. 2019

IJMS

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Diabetes mellitus is associated with cardiovascular, ophthalmic, and renal comorbidities. Among these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem worldwide. Exercise is widely known as an effective strategy for the prevention and treatment of many chronic diseases. Importantly, the onset of complications arising due to diabetes can be delayed or even prevented by exercise. Regular exercise is reported to have positive effects on diabetes mellitus and the development of DCM. The protective effects of exercise include prevention of cardiac apoptosis, fibrosis, oxidative stress, and microvascular diseases, as well as improvement in cardiac mitochondrial function and calcium regulation. This review summarizes the recent scientific findings to describe the potential mechanisms by which exercise may prevent DCM and heart failure.

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“…Descriptions of the condition, with varying degrees of complexity, have been published. 1,6,7 They all have something in common: a disease of a heart muscle develops in patients with diabetes who have no other cardiac conditions such as valvular, ischemic, or hypertensive disease. A novel definition has been proposed: DCM is a long-term process that affects the myocardium from the early stage of metabolic changes.…”

Section: What Is Diabetic Cardiomyopathy?mentioning

confidence: 99%

“…Assessment Study (CANVAS) trialS, which examined empagliflozin and canagliflozin respectively. 6,22 Other strategies proposed for DCM treatment include lifestyle modifications, vasoactive medications (such as beta-blockers and angiotensin-converting enzyme inhibitors), lipid-lowering drugs (such as statins), and metabolic modulators. 8,23,24 A classification for DCM has been created, using similar categories to the Treatment depends on the grade or type of HF and DCM.…”

Section: Does Diabetic Cardiomyopathy Have a Simple Physiopathology?mentioning

confidence: 99%

Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

Rodríguez-Ramos

2019

US Cardiology Review

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Diabetes is a major risk factor for heart disease. Diabetic cardiomyopathy is a long-lasting process that affects the myocardium in patients who have no other cardiac conditions. The condition has a complex physiopathology which can be subdivided into processes that cause diastolic and/or systolic dysfunction. It is believed to be more common than reported, but this has not been confirmed by a large study. Diagnosis can involve imaging; biomarkers cannot be used to identify diabetic cardiomyopathy at an early stage. In people with diabetes, there should be a focus on prevention and, if diabetic cardiomyopathy develops, the objective is to delay disease progression. Further studies into identifying and managing diabetic cardiomyopathy are essential to reduce the risk of heart failure in people with diabetes.

show abstract

Diabetes-related cardiomyopathy: The sweet story of glucose overload from epidemiology to cellular pathways

Cited by 66 publications

References 134 publications

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review

Exercise as A Potential Therapeutic Target for Diabetic Cardiomyopathy: Insight into the Underlying Mechanisms

Diabetic Cardiomyopathy: Five Major Questions with Simple Answers

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