Background: Appropriate diabetic self-care is indispensable to prevent and limit diabetic associated short and long term complications including death. Therefore, this comprehensive systematic review and meta-analysis were aimed at exploring and determining the pooled national percentage of diabetic self-care and its determinants among adult diabetic patients in Ethiopian.Methods: Different electronic databases including PubMed/Medline and search engines such as Google scholar were used to retrieve published studies. The Joanna Briggs Institute (JBI) quality appraisal checklists were used to appraise the quality of studies. Data were extracted using excel spreadsheets and analyses were done by STATA 14. Heterogeneity among studies was diagnosed using the I2. The DerSimonian and Laird random-effects model was employed for substantial heterogeneity (I2>50%).Sensitivity and subgroup analyses were carried out. The funnel plot and Egger's regression test was used to identify publication bias. Moreover, the nonparametric trim and fill analysis was done for findings with significant Egger's test (p<0.05) and asymmetric distribution of studies in the funnel plot. The pooled estimate of diabetic self-care and odds ratio was reported based on the 95% CI.Results: Well over half of the Ethiopian diabetic patients have good self-care 54.04% (47.07-61.01, I2 =97.3, P<0.001). Subgroup analysis showed that the highest and the lowest pooled estimate of selfcare was detected in Southern Nations Nationalities and Peoples and Hareri region with 81.96% and 44.53% respectively. Being knowledgeable about diabetes mellitus 2.69%, having good social support 2.25%, owning private glucometer 3.04%, and being urban residents 3.26% have promoted diabetic victims to apply self-care practice.Conclusions: Despite the life-threatening complications of diabetes mellitus, the percentage of patients applying self-care has remained low in Ethiopia, depicting the high proportion of diabetic patients are prone to develop long and short term life-threatening consequences of diabetes mellitus. Therefore, improving the client's awareness about the disease and counseling clients about the significance of social support are believed to be possible strategies to improve self-care practice and policymakers are strongly recommended to combat diabetic associated complications to attain sustainable development goal 3.4 aims to reduce premature death.