Diabetes risk associated with plasma epoxylipid levels

Imig, John D.

doi:10.1016/j.ebiom.2021.103331

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Supplemental feeding of concentrate in the experiment increased the content of ribulose-5-phosphate in the pancreas of suckling yak calves, indicating that supplemental feeding of concentrate can improve the regulation of glucose metabolism and lipid metabolism in early yak calves and create favorable conditions for their healthy growth. (+/-)5(6)-EET has been shown to have biological effects such as vasodilatory, anti-inflammatory and sodium-urea effects, as well as to stimulate insulin and glucagon secretion from an isolated pancreas [ 38 ], increase insulin sensitivity and lower blood pressure in rats, and increasing (+/-)5(6)-EET levels improved insulin sensitivity and reduced diabetes-related cardiovascular and renal damage. In this experiment, supplementation with concentrate increased (+/-)5(6)-EET levels in the pancreas of suckling yak calves, verified increased insulin and glucagon levels in the pancreas and positively regulated insulin sensitivity and glucose levels during the growth and development of early yak calves.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Supplemental Concentrate Feeding on the Morphological and Functional Development of the Pancreas in Early Weaned Yak Calves

Jiao

Liu

Zhou

et al. 2022

Animals

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This experiment was conducted to investigate the effect of supplemental concentrate feeding on the pancreatic development of yak calves. Twenty one-month-old yak calves with healthy body condition and similar body weight were selected as experimental animals and randomly divided into two groups, five replicates in each group. The control group yak calves were fed milk replacer and alfalfa hay, the experimental group yak calves were fed milk replacer, alfalfa hay and concentrate. The pre-feeding period of this experiment was thirty days, the trial period was one hundred days. At the end of feeding trail, five yak calves from each group were selected and slaughtered and the pancreas tissues of yak calves were collected and determined. The results showed that: (1) Dry matter and body weight of yak calves in the test group were significantly higher than those of the control group. (2) The apparent nutrient digestibility of crude protein, crude fat, calcium and phosphorus in the test group of yak calves was significantly higher than that of the control group, while the apparent nutrient digestibility of neutral detergent fiber and acid detergent fiber in the test group was significantly lower than that of the control group. (3) Pancreatic weight, organ index, total ratio of exocrine part area and total ratio of endocrine area of yak calves in the test group were significantly higher than those in the control group, while the ratio of exocrine area was significantly lower in the test group than that of the control group. (4) The activities of the main pancreatic digestive enzymes: pancreatic amylase, pancreatic lipase, pancreatic protease and chymotrypsin were significantly higher in the test group than those of the control group, as were the hormonal contents of glucagon, insulin and pancreatic polypeptide. (5) The main differential metabolites of the pancreas in the test group were significantly higher than those of the control group, such as D-proline, hypoxanthine, acetylcysteine, gamma-glutamylcysteine, thiazolidine-4-carboxylic acid, piperidinic acid, ellagic acid, nicotinamide, tropolone, D-serine, ribulose-5-phosphate, (+/-)5(6)-epoxyeicosatrienoic acid(EET), 2-hydroxycinnamic acid, L-phenylalanine, creatinine, tetrahydrocorticosterone, pyridoxamine, xanthine, 5-oxoproline, asparagine, DL-tryptophan, in-dole-3-acrylic acid, thymine, trehalose, docosapentaenoic acid, docosahexaenoic acid, fatty acid esters of hydroxy fatty acids(FAHFA) (18:1/20:3), fatty acid esters of hydroxy fatty acids(FAHFA) (18:2/20:4), adrenic acid and xanthosine. In conclusion, supplemental concentrate feeding promoted the good development of morphological and functional properties of the pancreas in early weaned yak calves to improve the digestion and absorption of feed nutrients, so as to enhance the growth and development quality of early weaned yak calves.

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Section: Discussionmentioning

confidence: 99%