Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease

Rooney, D. P.; Ryan, M. F.

doi:10.1111/j.1464-5491.2006.01855.x

Cited by 31 publications

(30 citation statements)

References 15 publications

(19 reference statements)

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“…Consistent with this, in our six patients with lipodystrophy, > 9 yr had elapsed since the initial HSCT. This observation is in accordance with previous reports, in which almost a decade was necessary for either lipodystrophy or diabetes to develop following HSCT (9, 10, 12,13,14). …”

Section: Discussionsupporting

confidence: 93%

“…In previous reports of HSCT-related lipodystrophy (9, 10, 12, 14), including our study (13), all patients had undergone TBI. Mayson et al .…”

Section: Discussionmentioning

confidence: 88%

“…Some authors have suggested that these features resemble the phenotype of partial lipodystrophy. However, partial lipodystrophy following HSCT has rarely been reported (9, 10, 12,13,14). We suggest that this discrepancy derives from both the poor recognition of lipodystrophy as a disease entity and the challenges associated with the diagnosis of partial lipodystrophy.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the aforementioned studies, partial lipodystrophy following HSCT has rarely been reported (13, 14). The difficulty in diagnosing partial lipodystrophy, mainly due to the absence of both diagnostic criteria and biomarkers, is likely the main reason for limited reports.…”

Section: Introductionmentioning

confidence: 99%

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Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey

Adachi

Oto

Muroya

et al. 2017

Clin Pediatr Endocrinol

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Abstract.Partial lipodystrophy (PD), a condition similar to metabolic syndrome without obesity, is one of the late complications of hematopoietic stem cell transplantation (HSCT) performed during childhood. We aimed to investigate the prevalence and risk factors of PD. A cross-sectional survey was performed in a children’s hospital, targeting patients treated for a malignancy or hematological disorder, and who were disease-free for > 24 mo. PD was defined as gluteal lipoatrophy and lipohypertrophy of the cheeks or neck associated with diabetes and/or fatty liver disease. In total, 65 patients were enrolled. Six patients (9.2%) were judged to have PD, all of whom had received 10–14 Gy total body irradiation. Compared with the patients without PD, patients with PD were older at investigation (P < 0.01), had a longer elapsed time following HSCT (P < 0.01), had more frequent disease recurrence (P < 0.05), and were more likely to have undergone multiple HSCT (P < 0.05). In addition, they had higher blood pressure and showed higher levels of low-density lipoprotein-cholesterol and triglycerides, whereas their adiponectin levels were significantly lower. In conclusion, a large number of patients developed PD following HSCT, with unfavorable metabolic profiles at a later age, especially when they experienced a complex disease course.

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Section: Discussionsupporting

confidence: 93%

“…In previous reports of HSCT-related lipodystrophy (9, 10, 12, 14), including our study (13), all patients had undergone TBI. Mayson et al .…”

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey

Adachi

Oto

Muroya

et al. 2017

Clin Pediatr Endocrinol

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“…Each year a variety of medical procedures are required for the repair of adipose tissue traumas and abnormalities, including breast reconstructions following mastectomies [1], cosmetic facial reconstructions of the cheek, chin, and jaw [2,3], and lipodystrophies associated with type II diabetes [4]. Currently, autologous and allogenic adipose tissues represent a ubiquitous source of material for fat reconstructive therapies.…”

Section: Introductionmentioning

confidence: 99%

Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds

et al. 2007

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Biomaterials derived from silk fibrion prepared by aqueous (AB) and organic (HFIP) solvent based processes, along with collagen (COL) and poly-lactic acid (PLA) based scaffolds were studied in vitro and in vivo for their utility in adipose tissue engineering strategies. For in vitro studies, human bone marrow and adipose-derived mesenchymal stem cells (hMSCs and hASCs) were seeded on the various biomaterials and cultured for 21 days in the presence of adipogenic stimulants (AD) or maintained as noninduced controls. Alamar Blue analysis revealed each biomaterial supported initial attachment of hMSCs and hASCs to similar levels for all matrices except COL in which higher levels were observed. hASCs and hMSCs cultured on all biomaterials in the presence of AD showed significant upregulation of adipogenic mRNA transcript levels (LPL, GLUT4, FABP4, PPARγ, adipsin, ACS) to similar extents when compared to noninduced controls. Similarly Oil-Red O analysis of hASC or hMSC-seeded scaffolds displayed substantial amounts of lipid accumulating adipocytes following cultivation with AD. The data revealed AB and HFIP scaffolds supported similar extents of lipid accumulating cells while PLA and COL scaffolds qualitatively displayed lower and higher extents by comparison, respectively. Following a 4 week implantation period in a rat muscle pouch defect model, both AB and HFIP scaffolds supported in vivo adipogenesis either alone or seeded with hASCs or hMSCs as assessed by Oil-Red O analysis, however the presence of exogenous cell sources substantially increased the extent and frequency of adipogenesis observed. In contrast, COL and PLA scaffolds underwent rapid scaffold degradation and were irretrievable following the implantation period. The results suggest that macroporous 3D AB and HFIP silk fibroin scaffolds offer an important platform for cell-based adipose tissue engineering applications, and in particular, provide longer-term structural integrity to promote the maintenance of soft tissue in vivo.

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Other Acquired Disorders of Subcutaneous Fat

Chen

Garg

2016

Rook's Textbook of Dermatology, Ninth Edition

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Diabetes with partial lipodystrophy following sclerodermatous chronic graft vs. host disease

Cited by 31 publications

References 15 publications

Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey

Partial lipodystrophy in patients who have undergone hematopoietic stem cell transplantation during childhood: an institutional cross-sectional survey

Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds

Other Acquired Disorders of Subcutaneous Fat

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