Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Crisafulli, Antonio; Pagliaro, Pasquale; Roberto, Silvana; Cugusi, Lucia; Mercuro, Giuseppe; Lazou, Antigone; Beauloye, Christophe; Bertrand, Luc; Hausenloy, Derek J.; Aragno, Manuela; Penna, Cláudia

doi:10.3390/ijms21082896

Cited by 47 publications

(35 citation statements)

References 153 publications

(188 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Finally, there are few and weak data about the beneficial cardio-metabolic effects of uncommon physical activities like aquatic exercise, Nordic walking, Yoga, Pilates, Tai Chi, and dance [89][90][91][92]. However, these data need to be further confirmed by studies with larger cohort of individuals and with longer follow-up [93].…”

Section: Non-pharmacological Modulation Of the Raas And Irmentioning

confidence: 99%

Modulation of insulin resistance by renin angiotensin system inhibitors: implications for cardiovascular prevention

Valente¹,

Izzo²,

Manzi³

et al. 2021

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

Insulin resistance (IR) and the related hyperinsulinamia play a key role in the genesis and progression of the continuum of cardiovascular (CV) disease. Thus, it is reasonable to pursue in primary and secondary CV prevention, the pharmacological strategies that are capable to interfere with the development of IR. The renin-angiotensin-aldosterone system (RAAS) plays an important role in the pathogenesis of IR. In particular, angiotensin II (Ang II) through the generation of reactive oxygen species, induces a low grade of inflammation, which impairs the insulin signal transduction. The angiotensin converting enzyme (ACE) inhibitors are effective not only as blood pressure-lowering agents, but also as modulators of metabolic abnormalities. Indeed, experimental evidence indicates that in animal models of IR, ACE inhibitors are capable to ameliorate the insulin sensitivity. The Ang II receptor blockers (ARBs) modulate the peroxisome proliferator-activated receptor (PPAR)-Î³ activity. PPARâ€“Î³ is a transcription factor that controls the gene expression of several key enzymes of glucose metabolism. A further mechanism that accounts for the favorable metabolic properties of ARBs is the capability to modulate the hypothalamicâ€“pituitary-adrenal (HPA) axis. The available clinical evidence is consistent with the concept that both ACE inhibitors and ARBs are able to interfere with the development of IR and its consequences like type 2 diabetes. In addition, pharmacological inhibition of the RAAS has favourable effects on dyslipidaemias, metabolic syndrome and obesity. Therefore, the pharmacological antagonism of the RAAS, nowadays, represents the first choice in the prevention of cardio-metabolic diseases.

show abstract

Section: Non-pharmacological Modulation Of the Raas And Irmentioning

confidence: 99%

Modulation of insulin resistance by renin angiotensin system inhibitors: implications for cardiovascular prevention

Valente¹,

Izzo²,

Manzi³

et al. 2021

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

show abstract

“…Due to their ability to carry their cargo, consisting of proteins, lipids, aminoacids, mRNAs, and miRNAs, circulating EV can be exploited as promising biomarkers for comorbidities of ischaemic conditions [ 23 , 24 ]. In addition to affecting the susceptibility of the myocardium to the ischaemia/reperfusion insult and the efficacy of classical cardioprotective interventions such as ischaemic conditioning [ 10 , 25 ], comorbidities may impact EV characteristics, modulating their composition, abundance, and function.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles in Comorbidities Associated with Ischaemic Heart Disease: Focus on Sex, an Overlooked Factor

Penna

Femminò

Alloatti

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

Extracellular vesicles (EV) are emerging early markers of myocardial damage and key mediators of cardioprotection. Therefore, EV are becoming fascinating tools to prevent cardiovascular disease and feasible weapons to limit ischaemia/reperfusion injury. It is well known that metabolic syndrome negatively affects vascular and endothelial function, thus creating predisposition to ischemic diseases. Additionally, sex is known to significantly impact myocardial injury and cardioprotection. Therefore, actions able to reduce risk factors related to comorbidities in ischaemic diseases are required to prevent maladaptive ventricular remodelling, preserve cardiac function, and prevent the onset of heart failure. This implies that early diagnosis and personalised medicine, also related to sex differences, are mandatory for primary or secondary prevention. Here, we report the contribution of EV as biomarkers and/or therapeutic tools in comorbidities predisposing to cardiac ischaemic disease. Whenever possible, attention is dedicated to data linking EV to sex differences.

show abstract

“…Endurance training (ET), as the most popular type of exercise training, is considered as the most effective for DM patients [ 29 , 30 ]. There are also no reports on ET side effects in DM patients, highlighting its safety for DM treatment [ 27 , 28 , 31 , 32 ]. In addition, it has been suggested that ET could lead to vascular modifications associated with capillary density and angiogenesis [ 3 , 33 , 34 , 35 ] and result in cardiac remolding.…”

Section: Introductionmentioning

confidence: 99%

Endurance Training Regulates Expression of Some Angiogenesis-Related Genes in Cardiac Tissue of Experimentally Induced Diabetic Rats

et al. 2021

View full text Add to dashboard Cite

Exercise can ameliorate cardiovascular dysfunctions in the diabetes condition, but its precise molecular mechanisms have not been entirely understood. The aim of the present study was to determine the impact of endurance training on expression of angiogenesis-related genes in cardiac tissue of diabetic rats. Thirty adults male Wistar rats were randomly divided into three groups (N = 10) including diabetic training (DT), sedentary diabetes (SD), and sedentary healthy (SH), in which diabetes was induced by a single dose of streptozotocin (50 mg/kg). Endurance training (ET) with moderate-intensity was performed on a motorized treadmill for six weeks. Training duration and treadmill speed were increased during five weeks, but they were kept constant at the final week, and slope was zero at all stages. Real-time polymerase chain reaction (RT-PCR) analysis was used to measure the expression of myocyte enhancer factor-2C (MEF2C), histone deacetylase-4 (HDAC4) and Calmodulin-dependent protein kinase II (CaMKII) in cardiac tissues of the rats. Our results demonstrated that six weeks of ET increased gene expression of MEF2C significantly (p < 0.05), and caused a significant reduction in HDAC4 and CaMKII gene expression in the DT rats compared to the SD rats (p < 0.05). We concluded that moderate-intensity ET could play a critical role in ameliorating cardiovascular dysfunction in a diabetes condition by regulating the expression of some angiogenesis-related genes in cardiac tissues.

show abstract

Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

Cited by 47 publications

References 153 publications

Modulation of insulin resistance by renin angiotensin system inhibitors: implications for cardiovascular prevention

Modulation of insulin resistance by renin angiotensin system inhibitors: implications for cardiovascular prevention

Extracellular Vesicles in Comorbidities Associated with Ischaemic Heart Disease: Focus on Sex, an Overlooked Factor

Endurance Training Regulates Expression of Some Angiogenesis-Related Genes in Cardiac Tissue of Experimentally Induced Diabetic Rats

Contact Info

Product

Resources

About