1878
DOI: 10.1136/bmj.1.890.78
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Diabetic Coma: Acetonaemia

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Cited by 7 publications
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“…Several case reports followed this publication, describing patients with newly diagnosed or previously known diabetes presenting with drowsiness or coma, most of them with a peculiar breath odor resembling acetone ( 9 ). In 1857, Petters ( 10 ) detected a substance in the urine of a fatal case of diabetic coma that resembled acetone in its reaction with sulfuric acid and caustic alkalis and was later recognized as acetoacetic acid, also called diacetic acid ( 11 , 12 ). Acetone was then recognized as an important outcome marker warning physicians about serious diseases, including diabetes ( 13 , 14 ).…”
Section: Introductionmentioning
confidence: 99%
“…Several case reports followed this publication, describing patients with newly diagnosed or previously known diabetes presenting with drowsiness or coma, most of them with a peculiar breath odor resembling acetone ( 9 ). In 1857, Petters ( 10 ) detected a substance in the urine of a fatal case of diabetic coma that resembled acetone in its reaction with sulfuric acid and caustic alkalis and was later recognized as acetoacetic acid, also called diacetic acid ( 11 , 12 ). Acetone was then recognized as an important outcome marker warning physicians about serious diseases, including diabetes ( 13 , 14 ).…”
Section: Introductionmentioning
confidence: 99%
“…The disease’s first manifestations develop when lack of insulin prevents cells from adequate glucose uptake, which is necessary and vital to cell function. Classic symptoms include polyuria, polydipsia, weight loss, fatigue, and hyperglycemia, which, if left untreated, can lead to a coma and ultimately to death [ 57 ]. Diagnosis of diabetes includes fasting blood glucose higher than 126 mg/dL, any blood glucose of 200 mg/dL or an abnormal oral glucose-tolerance test [ 58 ].…”
Section: Type-1 Diabetesmentioning
confidence: 99%