Diabetic control in patients treated with once or twice-daily insulin injections, including a comparison of conventional beef and highly purified pork insulins

Gray, R S; Borsey, D. Q.; Fraser, D M; Kurtz, A. B.; Rainbow, S; Smith, A. F.; Duncan, L. J. P.; Clarke, B F

doi:10.1007/bf00252655

Cited by 4 publications

(1 citation statement)

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“…With declining pancreatic B-cell function, diabetic control in patients receiving a once daily conventional beef insulin regime might benefit from the formation of anti-insulin antibodies. However, we have found (Gray, Borsey, Fraser, Kurtz, Rainbow, Smith, Duncan and Clarke 1981) that a twice daily insulin regime is accompanied by lower HbAl levels than a once daily regime, and should, therefore, be recommended for all such patients. The presence of insulin antibodies may not offer the same advantage to patients treated with two injections of insulin daily.…”

Section: Discussionmentioning

confidence: 91%

Relationship of Glycosylated Haemoglobin to C-Peptide Secretory Status and Antibody Binding of Insulin in Insulin-Dependent Diabetes

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Dq²,

Kurtz³

et al. 1981

Horm Metab Res

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Diabetic control, assessed by measuring the concentration in venous blood of total glycosylated haemoglobin (HbA1), endogenous insulin secretion, as estimated by the C-peptide response (delta C-P) to intravenous glucagon, and serum beef insulin antibody binding were measured in 50 juvenile onset insulin dependent diabetics (IDDM) receiving a single daily injection of soluble and protamine zinc insulin. The delta C-P correlated inversely with duration of diabetes (tau = -0.27, p less than 0.01) and daily insulin requirement (tau = -0.22, p less than 0.05) in the 50 IDDM studied of whom 28 exhibited a measurable delta C-P. In C-peptide nonresponders, but not in the C-peptide responders, and inverse regression (t = 2.19, p less than 0.05) was observed between beef insulin antibody and HbA1. In the 25 IDDM having the lowest insulin antibody binding, and inverse correlation (tau = 0.36, p less than 0.02) was observed between delta CP and HbA1, which was not found (tau = 0.05) in the remaining 25 IDDM who had the highest insulin antibody binding. These findings suggest that, in the absence of endogenous insulin secretion, diabetic control in IDDM receiving a single daily injection of conventional beef insulin is better in patients with high beef insulin antibody binding. Conversely, in patients with low beef insulin antibody binding, diabetic control appears to be better in those with persisting endogenous insulin secretion.

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Section: Discussionmentioning

confidence: 91%