Diabetic cystopathy in children and adolescents with Type 1 diabetes mellitus

Salem, Mona A.; Habashy, Safinaz A. El; Toaima, Dalia N.; Shaker, Hassan; Hetta, Osama M.; Kafy, Jonair H. A. El

doi:10.4236/jdm.2014.41004

Cited by 2 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is contrary to the findings in the study done by Salem et al ( 32 ) among diabetic children, whereby the average value of bladder wall thickness was almost the same in both neuropathic and non-neuropathic diabetic patients probably due to a lesser duration of DM in these type 1 diabetes mellitus patients compared to the type 2 DM in the index study. Also, the mean rise in estimated bladder weight in patients with neuropathy and those without was similar.…”

Section: Discussioncontrasting

confidence: 99%

“…Among the 80 diabetic mellitus patients included in this study, only three (3.75%), who were females, presented with urinary tract symptoms. This is similar to the findings in the study done by Salem et al ( 32 ) , where only two (10%) of the 20 non-neuropathy diabetic patients had obstructive and overactive symptoms. Also, 22 (36.7%) out of the 60 neuropathy diabetic patients presented with lower urinary tract symptoms.…”

Section: Discussionsupporting

confidence: 92%

“…Evidence suggested an increased prevalence of urgency with or without urge urinary incontinence among women with type 2 diabetes in the study done by Brown et al ( 17 ) that involved 7,949 community dwelling women in the USA, and an increasing pattern with a longer duration of diabetes ( 18 ) . This was not the same in the study done by Salem et al ( 32 ) , where the duration of diabetes was found to be statistically significant in relationship with the ultrasound estimated BWT ( p = 0.018), but not significantly related to any of the recorded urodynamic parameters in their study.…”

Section: Discussioncontrasting

confidence: 59%

See 2 more Smart Citations

Urinary bladder wall thickness in type 2 diabetes mellitus patients

et al. 2022

View full text Add to dashboard Cite

Introduction: Diabetes mellitus is an increasing health challenge with accompanying urological complications. Over 50% of men and women with diabetes have bladder dysfunction. According to the current understanding of bladder dysfunction, it refers to a progressive condition encompassing a broad spectrum of lower urinary tract symptoms including urinary urgency, frequency, nocturia, and incontinence. Urinary bladder dysfunction has been classically described as diminished bladder sensation, poor contractility, and increased post-void residual urine, termed bladder cystopathy. Ultrasonography of the urinary bladder, which is a cheap, safe, radiation free, non-invasive and reliable imaging modality, may help to identify diabetes mellitus patients prone to develop urinary bladder dysfunction. Method: The study population comprised 80 diabetic subjects recruited from the diabetic outpatient clinic and another 80 age- and sex-matched asymptomatic control subjects. Ultrasound scan of their urinary bladder wall was performed using a curvilinear transducer to determine the thickness and other sonographic features. Results: Out of the 80 diabetic subjects, 30 (37.5%) were males, while 50 (62.5%) were females; of 80 non-diabetic control subjects, 40 (50%) were males and 40 (50%) were females. The mean age of the diabetic subjects was 59.5 ± 10.4 years with a range of 40–82 years, while that of the controls was 60.2 ± 7.4 years with a range of 40–85 years. There was no statistically significant difference (p = 0.637) between the mean age of the diabetic and control subjects. The mean urinary bladder wall thickness in the diabetics was greater than in the non-diabetics in the study subjects. There was a statistically significant difference between the urinary bladder thickness of diabetic subjects and the control group (p <0.001). The mean urinary bladder wall thickness of the male and female subjects included in this study was 2.84 ± 1.31 mm and 2.9 ± 1.37 mm, respectively, with no statistically significant difference between them (p = 0.159). It was statistically significant between diabetic men and women (p = 0.027). Using Spearman’s rank correlation to test the relationship between the glycaemic haemoglobin level of diabetic subjects and urinary bladder wall thickness, it was revealed that there was no correlation between these variables (Spearman’s rho = 0.119, p = 0.309). The relationship between the urinary bladder volume of diabetic subjects and their mean urinary bladder wall thickness showed no correlation either (Spearman’s rho = –0.009, p = 0.937). Only gender was a statistically significant predictor of urinary bladder wall thickness among other variables. Conclusion: Mean bladder wall thickness in patients with type 2 diabetes mellitus was greater than in the control subjects, and also greater in diabetic men compared to diabetic women, but the difference did not attain statistical significance. Urinary bladder wall thickness of the diabetics did not correlate with their glycaemic haemoglobin levels. Only gender was found to be a predictor of bladder wall thickness.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Urinary bladder wall thickness in type 2 diabetes mellitus patients

et al. 2022

View full text Add to dashboard Cite

show abstract

“…15 Recent studies suggest that uroflowmetry might determine autonomic neuropathy earlier than CAN symptoms occur. [16][17][18] Since DC can reduce the quality of life, it is urgent to be addressed before resulting in complications.…”

Section: Introductionmentioning

confidence: 99%

INvesTigating the Abnormality of detrusor ConTractility by uroflowmetry in diabetic children (INTACT Trial): protocol of a prospective, observational study

et al. 2022

View full text Add to dashboard Cite

IntroductionBladder emptying abnormalities and cardiovascular autonomic dysfunction are manifestations of autonomic dysfunction in people with diabetes mellitus (DM), which are major causes of morbidity and mortality. Since they can reduce the quality of life, they are urgent to be addressed before resulting in complications. As uroflowmetry might determine autonomic neuropathy earlier than cardiovascular autonomic dysfunction symptoms occur, our aim is to detect early abnormalities in bladder muscle function in children with DM. We investigate the diagnostic accuracy of uroflowmetry. As a secondary aim, we compare the prevalence of uroflowmetry abnormalities to the appearance of measures of cardiovascular autonomic neuropathy. Finally, as an ancillary study, we examine the association of uroflowmetry with the appearance of peripheral neuropathy. These three aims, we feel, will put our results regarding uroflowmetry into an overall context of nerve disease early in the course of type 1 DM. To our knowledge, such an approach has heretofore not been performed.Methods and analysisThis will be a prospective, observational, single-centre clinical study. Patients with DM fulfilling the inclusion criteria and healthy controls will have uroflowmetry examination, cardiovascular autonomic dysfunction tests (heart rate response to deep breathing, to Valsalva manoeuvre, blood pressure and heart rate response to standing up, and to sustained handgrip) and nerve conduction test. The autonomic nervous system function will be examined by the reproducible and standardised cardiovascular reflex tests described by Ewinget al. During the examination, electrocardiogram (ECG) and blood pressure values will be recorded continuously. Heart rate response to deep inspiration will be executed to investigate the parasympathetic nervous system. Peripheral neuropathy will be evaluated by nerve conduction test. After a pilot period, when the first 50 diabetic and 50 healthy children will be assessed, sample size calculation will be carried out. The primary objective of this trial is to evaluate the diagnostic accuracy (sensitivity, specificity, positive and negative predictive value) of uroflowmetry. To do so, we compare uroflowmetry to the gold standard neuropathy tests, which are cardiovascular autonomic dysfunction tests (heart rate response to deep breathing, to Valsalva manoeuvre, blood pressure and heart rate response to standing up and to sustained handgrip).Ethics and disseminationEthics approval was obtained from the Scientific and Research Ethics Committee of the Heim Pál National Paediatric Institute in Budapest, Hungary (registration number KUT-37/2021). Results will be submitted for publication in a peer-reviewed journal.Trial registration numberNCT05247840.

show abstract

Diabetic cystopathy in children and adolescents with Type 1 diabetes mellitus

Cited by 2 publications

References 25 publications

Urinary bladder wall thickness in type 2 diabetes mellitus patients

Urinary bladder wall thickness in type 2 diabetes mellitus patients

INvesTigating the Abnormality of detrusor ConTractility by uroflowmetry in diabetic children (INTACT Trial): protocol of a prospective, observational study

Contact Info

Product

Resources

About