Diabetic dyslipidemia impairs coronary collateral formation: An update

Abstract

Coronary collateralization is substantially impaired in patients with type 2 diabetes and occlusive coronary artery disease, which leads to aggravated myocardial ischemia and a more dismal prognosis. In a diabetic setting, altered serum lipid profiles and profound glycoxidative modification of lipoprotein particles induce endothelial dysfunction, blunt endothelial progenitor cell response, and severely hamper growth and maturation of collateral vessels. The impact of dyslipidemia and lipid-lowering treatments on coronary collateral formation has become a topic of heightened interest. In this review, we summarized the association of triglyceride-based integrative indexes, hypercholesterolemia, increased Lp(a) with its glycoxidative modification, as well as quantity and quality abnormalities of high-density lipoprotein with impaired collateral formation. We also analyzed the influence of innovative lipid-modifying strategies on coronary collateral development. Therefore, clinical management of diabetic dyslipidemia should take into account of its effect on coronary collateralization in patients with occlusive coronary artery disease.

Elevated uric acid/albumin ratio as a predictor of poor coronary collateral circulation development in patients with non‐ST segment elevation myocardial infarction

“…Furthermore, CRP, a classic inflammatory maker, was significantly higher in patients with poorly developed CCC. These findings are consistent with those reported in previous research 6,20 . These associations are thought to be mediated by reduced production of NO and endothelial dysfunction.…”

“…These findings are consistent with those reported in previous research. 6,20 analysis, which is inconsistent with previous studies in stable CAD patients. 7 Previous investigations have reported that impaired renal function may be associated with poorly-developed CCC in CAD patients, 19,22 but our study found no statistical differences between renal function and CCC formation.…”

“…The role of inflammation and oxidative stress in CCC development is not clearly defined, but accumulating evidence suggests that inflammation and oxidative stress contribute to CCC development. [19][20][21] Additionally, previous research has shown that various inflammatory parameters were associated with CCC formation and the prognosis of cardiovascular diseases, independent of traditional factors such as diabetes and renal insufficiency. 6,7 In our study, we found that diabetes, as a traditional risk factor, was independently associated with poorly developed CCC.…”

Dyslipidemia Among Diabetes Mellitus Patients: A Case-Control Study From a Tertiary Care Hospital in South India

“…Previous studies have noted that an increase in the activities of LDL-C and dyslipidemia may predispose T2DM patients to coronary heart disease and can predict future cardiovascular complications [20,21]. The findings of this study demonstrated an increase in TC by 11.8% in T2DM patients compared to the nondiabetic population.…”

“…Coronary artery disease (CAD)/CVD is generally attributed to atherosclerosis of large and medium-sized arteries, and diabetic dyslipidemia has been reported as one of the most important contributing factors [18,20,21].…”