The growing trend of chronic non-communicable diseases, which affects both developed and developing countries, is linked to changes in diet and lifestyle. Despite numerous epidemiological pieces of evidence and recognized risk factors for the development of chronic non-communicable diseases, there are still worrying indicators of morbidity and premature mortality as a consequence of non-communicable chronic diseases. The goal of the work is to point out the urgent need to create effective and sustainable health policies that would provide answers to growing public health challenges. Additionally, the authors emphasize in the paper the key risk factors and the necessity of transforming patterns of inadequate behavior in order to mitigate, and in the future, to stop the unfavorable trend of newly diagnosed cardiovascular diseases, stroke, diabetes, and cancer, as the leading causes of disability and premature death, as well as to reduce the burden on health funds.