Diabetic foot infection caused by bacteria of the Burkholderia cepacia complex: report of an unusual case and a scoping literature review

Abstract

Burkholderia cepacia complex (BCC) is group of widespread gram-negative bacillus organized in over 20 phylogenetically distinct bacterial species. According to previous studies, BCC species pathogens are widely reported in patients with cystic fibrosis (CF), but not in individuals with diabetes mellitus (DM). In this case report, a 42-year-old male patient with DM and a foot infection caused by BCC is presented. The patient was hospitalized after antibiotic treatment failure and improved after two surgical debridement procedures and a high-dose extended infusion (EI) of meropenem. The team of vascular surgeons and the infectious disease specialists worked fervently to solve the case. Finally, a scoping review was conducted to map BCC infections in patients with DM.

Are Burkholderia Emerging Pathogens in patients with underlying morbidity: A case series

“… Patient completely recovered after follow-up remained free of infection. Reports from India [ 13 ] New Delhi B. cepacia Post-operative pyogenic spondylo-discitis Not mentioned IV meropenem 1 g thrice a day for six weeks followed by oral clindamycin six weeks Recovered Reports from worldwide [ 14 ] Brazil Burkholderia cepacian complex Injury with glass piece Muddy field worker IV Meropenem 2g six hourly for 2 weeks Recovered Septic arthritis Our case Case 6 Chennai B. pseudomallei Bilateral knee joint effusion Businessman Susceptible- co-trimoxazole, tetracycline, ceftazidime, amoxicillin-clavulanate, meropenem, doxycycline IV meropenem therapy 1 g every 6 h for two weeks and was recommended oral co-trimoxazole 480mg twice a day for six months. Patient made full recovery returns to full time work after 6 months of therapy Reports from India [ 15 ] Andaman and Nicobar Island Knee swelling Farmer IV ceftazidime 8 hourly for 3 weeks followed with oral co-trimoxazole and doxycycline for 5 weeks Recovered Reports from worldwide [ 16 ] Oman Left Knee joint septic arthritis Farmer IV meropenem and cefuroxime tablet Recovered B- Burkholderia ; Hb-Haemoglobin; SSI-Surgical site infection; IV-Intravenous.…”

Artificial Intelligence Methodologies Applied to Technologies for Screening, Diagnosis and Care of the Diabetic Foot: A Narrative Review

“…A small percentage of foot ulcers in patients with peripheral arterial disease are purely ischemic, and they are usually painful, but the majority of foot ulcers are either purely neuropathic or neuro-ischemic (that is, caused by combined neuropathy and ischemia), and they can often be asymptomatic [ 8 ]. Notably, the indicated factors can lead to foot ulcers of differing severity, possibly reaching a remarkable size and depth, as shown by images reported in several studies [ 9 , 10 , 11 , 12 , 13 ].…”