Diabetic Gastroparesis

Kalra, Sanjay; Sharma, Vishal; Priya, Gagan

doi:10.1007/s13300-018-0475-4

Cited by 15 publications

(18 citation statements)

References 20 publications

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“…Such "therapeutic adventures", akin to a pyromaniac leading a firefighting operation, may harm rather than improve DGP. A combination of acid-suppressing and prokinetic drugs is indicated only if dyspepsia and GP co-exist with each other [20] . Vagal dysfunction has also been postulated to play a role in DGP.…”

Section: Letter To the Editormentioning

confidence: 99%

Domination of Gastric Complications Among Diabetic Patients

Mohiuddin

2019

Journal of Gastroenterology and Hepatology Research

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This letter covers the epidemiology, pathophysiology/complications and management of diabetic gastroparesis (DGP), and more broadly diabetic gastroenteropathy, which encompasses all the gastrointestinal manifestations of diabetes mellitus (DM). Hyperglycemia, autonomic neuropathy, and enteric neuromuscular inflammation and injury are implicated in the pathogenesis of delayed gastric emptying (GE). Initial options include dietary modifications, supplemental oral nutrition, and antiemetic and prokinetic medications. Patients with more severe symptoms may require a venting gastrostomy or jejunostomy and/or gastric electrical stimulation (GES). To date, few population-based studies have estimated the true prevalence and incidence of gastroparesis. Nonetheless, its prevalence appears to be rising, as does its incidence among minority populations, documented via hospitalizations, which can impose significant economic burdens on patients.

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Section: Letter To the Editormentioning

confidence: 99%

Domination of Gastric Complications Among Diabetic Patients

Mohiuddin

2019

Journal of Gastroenterology and Hepatology Research

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“…Diabetic gastroparesis is a syndrome of delayed gastric emptying (GE) in the absence of mechanical obstruction of the upper stomach, antrum body, lower pyloric sphincter, and duodenum. Gastroparesis patients often experience symptoms including severe nausea, vomiting, and abdominal pain [2,3]. Emerging evidence strongly indicate that women and female rodents are likely to experience more severe disease manifestations of gastroparesis compared to males [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Gastroparesis patients often experience symptoms including severe nausea, vomiting, and abdominal pain [2,3]. Emerging evidence strongly indicate that women and female rodents are likely to experience more severe disease manifestations of gastroparesis compared to males [3,4]. In fact, women during their reproductive ages, tend to be disproportionately affected by gastroparesis because their stomach motility is slower to begin with, likely due to elevated levels of sex steroid hormones and nitric oxide [5,6].…”

Section: Introductionmentioning

confidence: 99%

Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model

2020

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Background Gastroparesis, a condition of abnormal gastric emptying, is most commonly observed in diabetic women. To date, the role of ovarian hormones and/or gastric hormone receptors on regulating nitrergic-mediated gastric motility remains inconclusive. Aim The purpose of this study is to investigate whether sex hormones/their receptors can attenuate altered Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), neuronal Nitric Oxide Synthase (nNOS) expression and nitrergic relaxation in gastric neuromuscular tissues exposed to in-vitro hyperglycemia (HG). Methods Gastric neuromuscular sections from adult female C57BL/6 J mice were incubated in normoglycemic (NG, 5 mM) or hyperglycemic (30 mM or 50 mM) conditions in the presence or absence of selective estrogen receptor (ER) agonists (ERα /PPT or ERβ: DPN); or non-selective sex hormone receptor antagonists (ER/ICI 182,780, or progesterone receptor (PR)/ RU486) for 48 h. mRNA, protein expression and nitrergic relaxation of circular gastric neuromuscular strips were assessed. Results Our findings in HG, compared to NG, demonstrate a significant reduction in ER, Nrf2, and nNOS expression in gastric specimens. In addition, in-vitro treatment with sex hormones and/or their agonists significantly (*p < 0.05) restored Nrf2/nNOSα expression and total nitrite production. Conversely, ER, but not PR, antagonist significantly reduced Nrf2/nNOSα expression and nitrergic relaxation. Conclusions Our data suggest that ER’s can regulate nitrergic function by improving Nrf2/nNOS expression in experimental hyperglycemia.

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“…[ 1 , 2 ] The main symptoms of DGP include prolonged postprandial fullness, early satiety, nausea, vomiting, anorexia, weight loss, with or without abdominal pain. [ 3 – 6 ] Due to delayed gastric emptying, DGP is easy to bring about impaired glycemic control, poor nutrition and hydration status, even worse frequent hospitalizations. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of acupoint injection for diabetic gastroparesis

Long¹,

Yue²,

Wu³

et al. 2020

Medicine

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Background: Diabetic gastroparesis (DGP) is one of the common complications of diabetes. Accumulated evidences have shown that acupoint injection is beneficial for the clinical treatment of diabetic gastroparesis. However, there is currently no systematic review to assess this therapy. This program aims to evaluate the effectiveness and safety of this therapy for the patients with DGP. Methods and analysis: Literature search will be conducted via following electronic bibliographic databases from inception to Aug 2020: the Cochrane Library, PubMed, MEDLINE, Web of Science, EMBASE, Springer, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chinese Scientific Journal Database (VIP), Wan-Fang Database. All randomized controlled trials published in English or Chinese related to acupoint injection for DGP will be included. The primary outcome is the total effective rate. The secondary outcomes are the change of motilin and gastrin levels before and after the treatment. Two researchers will be responsible for the selection of study, extraction of data, and assessment of study quality independently. RevMan V5.3 Software will be used for assessing the risk of bias and synthesizing data. Results: This study will provide a high-quality synthesis of current available evidence for the treatment of DGP with this therapy clinically. Conclusion: The conclusions of our study will provide new evidence to judge whether acupoint injection is an effective intervention for patients suffered from DGP. OSF registration number: osf.io/ms58j.

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Diabetic Gastroparesis

Cited by 15 publications

References 20 publications

Domination of Gastric Complications Among Diabetic Patients

Domination of Gastric Complications Among Diabetic Patients

Role of sex hormones and their receptors on gastric Nrf2 and neuronal nitric oxide synthase function in an experimental hyperglycemia model

The efficacy and safety of acupoint injection for diabetic gastroparesis

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