Diabetic gastroparesis: pathophysiology, evaluation and management

Farmer, Adam D.; Kadirkamanathan, S; Aziz, Qasim

doi:10.12968/hmed.2012.73.8.451

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…As expected from the previous data, camicinal stimulated gastric motility and reduced GET by 55% over and above placebo. Given that delayed gastric emptying has been implicated in the pathophysiology of the GI sequelae of a number of systemic disorders, most notably in diabetes mellitus and scleroderma, these findings in particular suggest that camicinal warrants further exploration in such patient groups. Although there were no significant differences from baseline on small bowel or colonic transit motility per se with camicinal, there was an overall decrease of 9.5 h in overall whole bowel transit.…”

Section: Discussionmentioning

confidence: 98%

“…The pathophysiology of a number of foregut disorders, including gastroparesis and gastro‐esophageal reflux disease (GERD), has been proposed to be centered around disordered or ineffective gastro‐esophageal motility . A diverse array of therapeutic interventions, including metoclopramide, domperidone, cisapride, macrolide antibiotics, and electrical stimulation have been utilized either alone or in combination . However, clinical outcomes are highly variable largely as a consequence of the lack of specificity therein, coupled with not insignificant concerns regarding safety .…”

Section: Introductionmentioning

confidence: 99%

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The effects of camicinal, a novel motilin agonist, on gastro‐esophageal function in healthy humans—a randomized placebo controlled trial

Hobson

Farmer

Dewit

et al. 2015

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

The effects of camicinal, a novel motilin agonist, on gastro‐esophageal function in healthy humans—a randomized placebo controlled trial

Hobson

Farmer

Dewit

et al. 2015

Neurogastroenterology Motil

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“…Insulinresistenz ist ein bekanntes Charakteristikum des Stoffwechsels der Kuh mit hoher Milchleistung in der frühen Laktation (27), die bei Kühen mit LDA festgestellt wurde (56). Eine diabetesbedingte Gastroparese ist aus der Humanmedizin bekannt (15).…”

Section: Genetikunclassified

Leistung und Gesundheit von Milchkühen: Bedeutung von Genetik (Ursache) und Management (Wirkung)

Martens¹

2016

Tierarztl Prax Ausg G

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The milk production of dairy cows has been increased during recent decades through animal-husbandry, improved feeding regime, extensive veterinary service and proper management. It can be assumed that this tendency will be continued in the future. However, the incidence of diseases (production diseases), including ketosis, fat liver, mastitis, lameness, metritis and disturbed fertility, has also increased and exhibits a close genetic correlation with milk yield. The pathogenesis of these diseases is - more or less - causally related to the negative energy balance and hence, is a consequence of selection for high milk yield. The genetic disposition and health risks are modulated by the management of dairy cows and both factors contribute to the large variation of diseases in practice. An analysis of production diseases must therefore distinguish between the genetic disposition (cause) and the management (effect). An effective improvement of the complex of production diseases includes the critical discussion of the current breeding index for dairy cows.

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“…Usually diabetes can be simply divided into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) due to different pathogenesis. As a result of the long-term existence of hyperglycemia, it often accompanied by a variety of diabetic complications [1], such as diabetes cardiomyopathy [2], diabetic ketoacidosis [3], diabetic gastroparesis [4], retinopathy [5], diabetic nephropathies [6]. These diabetes-related diseases not only have a huge impact on the body and spirit of the patients, but also bring great pressure to society.…”

Section: Introductionmentioning

confidence: 99%

Systemic elucidate the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

Song

Yang

Jing

et al. 2020

Preprint

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Background: Diabetes is a complex metabolic disease characterized by hyperglycemia, plaguing the whole world. However, the action mode of multi-component and multi-target for traditional Chinese medicine (TCM) could be a promising treatment of diabetes mellitus. According to the previous research, the TCM of polygonum multiflorum (PM) showed noteworthy hypoglycemic effect. Up to now, its hypoglycemic active ingredients and mechanism of action are not yet clear. In this study, network pharmacology was employed to elucidate the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum (PM).Methods: First, the compounds with good pharmacokinetic properties were screened from the self-established library of PM, and the targets of these compounds were predicted and collected through database. Relevant targets of diabetes were summarized by searching database. The intersection targets of compound-targets and disease-targets were obtained soon. Secondly, the interaction net between the compounds and the filtered targets was established. These key targets were enriched and analyzed by PPI analysis, molecular docking verification. Finally, the key genes were used to find the biologic pathway and explain the therapeutic mechanism by GO and KEGG analysis. Results: In this study, 29 hypoglycemic components and 63 hypoglycemic targets of PM were filtrated based on online network database. Then the component-target interaction network was constructed and five key components resveratrol, apigenin, kaempferol, quercetin and luteolin were further obtained. Sequential studies turned out, AKT1, EGFR, ESR1, PTGS2, MMP9, MAPK14, and KDR were the common key targets. Docking studies indicated that the bioactive compounds could stably bind the pockets of target proteins. There were 38 metabolic pathways, including regulation of lipolysis in adipocytes, prolactin signaling pathway, TNF signaling pathway, VEGF signaling pathway, FoxO signaling pathway, estrogen signaling pathway, linoleic acid metabolism, Rap1 signaling pathway, arachidonic acid metabolism, and osteoclast differentiation closely connected with the hypoglycemic mechanism of PM.Conclusion: In summary, the study used systems pharmacology to elucidate the main hypoglycemic components and mechanism of PM. The work provided a scientific basis for the further hypoglycemic effect research of PM and its monomer components, but also provided a reference for the secondary development of PM.

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Diabetic gastroparesis: pathophysiology, evaluation and management

Abstract: As the incidence of diabetes mellitus inexorably rises, the burden of its complications is becoming increasingly problematic. Among the most bothersome, but often under-recognized, inadequately investigated and poorly managed, is diabetic gastroparesis.

Cited by 13 publications

References 23 publications

The effects of camicinal, a novel motilin agonist, on gastro‐esophageal function in healthy humans—a randomized placebo controlled trial

The effects of camicinal, a novel motilin agonist, on gastro‐esophageal function in healthy humans—a randomized placebo controlled trial

Leistung und Gesundheit von Milchkühen: Bedeutung von Genetik (Ursache) und Management (Wirkung)

Systemic elucidate the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology

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