2007
DOI: 10.1111/j.1464-5491.2007.02200.x
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Diabetic ketoacidosis and cerebral oedema in Sweden—a 2‐year paediatric population study

Abstract: We conclude that 16% of children with new-onset diabetes presented with DKA at diagnosis and that the incidence of DKA in children with established diabetes was 1.6/100 patient years. Cerebral oedema occurred in 0.68% of the DKA episodes.

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Cited by 71 publications
(69 citation statements)
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“…A higher DKA rate was observed in the youngest age group (<5 years), which is consistent with previous studies undertaken in countries with a high incidence of type 1 diabetes [4,10,14,16,29]. The very young children (<2 years) had an undesirably high prevalence of DKA (48.3%), comparable with register studies from Sweden, Finland and Germany (39.5-54.9%) [15,30,31]. The subtlety of the symptoms in infants and toddlers presents a challenge in diagnosing this age group [32].…”
Section: Discussionsupporting
confidence: 80%
“…A higher DKA rate was observed in the youngest age group (<5 years), which is consistent with previous studies undertaken in countries with a high incidence of type 1 diabetes [4,10,14,16,29]. The very young children (<2 years) had an undesirably high prevalence of DKA (48.3%), comparable with register studies from Sweden, Finland and Germany (39.5-54.9%) [15,30,31]. The subtlety of the symptoms in infants and toddlers presents a challenge in diagnosing this age group [32].…”
Section: Discussionsupporting
confidence: 80%
“…Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes and is present in 15-67% of children at the time of diagnosis [1][2][3][4][5][6][7]. The prevalence of onset DKA varies widely among studies, but most studies have been hospital-based and might therefore have been influenced by the selection bias of hospital referral [2,4,6].…”
Section: Introductionmentioning
confidence: 99%
“…Although major research interests in T1D are focused on children at risk, the clinical reality is still that the vast majority of children are first seen at the time when symptoms of diabetes appear. As the frequency of children diagnosed with diabetes in conjunction with ketoacidosis tends to decrease [19], it may sometimes be unclear if the patient has T1D at the time of presentation. Analyzing islet autoantibodies at diagnosis should prove helpful in this respect.…”
Section: Introductionmentioning
confidence: 99%