Diabetic ketoacidosis and invasive aspergillosis

Grizzanti, Joseph N.; Knapp, Anne‐Marie

doi:10.1007/bf02713896

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…These factors, which are all involved in immune defenses against fungal invasion [15], may predispose diabetic patients to infection. Among opportunistic infections, however, invasive pulmonary aspergillosis is rare in patients with diabetic ketoacidosis [10][11][12][13]. We showed herein such a patient, who was successfully treated with L-AMB.…”

Section: Discussionmentioning

confidence: 86%

“…We showed herein such a patient, who was successfully treated with L-AMB. To the best of our knowledge, only 4 cases of invasive pulmonary aspergillosis with diabetic ketoacidosis have been reported [10][11][12][13]. In 1981, Grizzanti et al reported a 57-year-old female patient with diabetic ketoacidosis and invasive aspergillosis [10].…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, only 4 cases of invasive pulmonary aspergillosis with diabetic ketoacidosis have been reported [10][11][12][13]. In 1981, Grizzanti et al reported a 57-year-old female patient with diabetic ketoacidosis and invasive aspergillosis [10]. They treated her with amphotericin-B, and at discharge from the hospital, she was asymptomatic and her chest radiograph was normal [10].…”

Section: Discussionmentioning

confidence: 99%

“…In 1981, Grizzanti et al reported a 57-year-old female patient with diabetic ketoacidosis and invasive aspergillosis [10]. They treated her with amphotericin-B, and at discharge from the hospital, she was asymptomatic and her chest radiograph was normal [10]. Subsequently, Janes et al presented a 45-year-old male patient, who was successfully treated with amphotericin-B colloidal dispersion, L-AMB [11].…”

Section: Discussionmentioning

confidence: 99%

“…However, cases have been reported in non-immunocompromised individuals, in whom the infection was associated with alcoholism, diabetes mellitus, steroid therapy, or influenza virus infection [6][7][8][9]. Diabetic ketoacidosis is an emergent condition, in which invasive pulmonary aspergillosis has rarely been reported [10][11][12][13]. We report herein invasive pulmonary aspergillosis successfully treated with liposomal amphotericin-B (L-AMB) in a patient with diabetic ketoacidosis.…”

Section: Introductionmentioning

confidence: 99%

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Successfully treated invasive pulmonary aspergillosis in a patient with diabetic ketoacidosis

et al. 2013

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Successfully treated invasive pulmonary aspergillosis in a patient with diabetic ketoacidosis

et al. 2013

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Invasive pulmonary aspergillosis and influenza co-infection in immunocompetent hosts: case reports and review of the literature

Shah

Hsiao

Kirsch

et al. 2018

Diagnostic Microbiology and Infectious Disease

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Invasive pulmonary aspergillosis (IPA) is classically considered an illness of severely immunocompromised patients with limited host defenses. However, IPA has been reported in immunocompetent but critically ill patients. This report describes two fatal cases of pathologically confirmed IPA in patients with Influenza in the intensive care unit. One patient had Influenza B infection, whereas the other had Influenza A H1N1. Both patients died despite broad-spectrum antimicrobials, mechanical ventilation, and vasopressor support. Microscopic and histologic postmortem examination confirmed IPA. Review of the English language and foreign literature indicates that galactomannan antigen testing and classic radiologic findings for IPA may not be reliable in immunocompetent patients. Respiratory cultures which grow Aspergillus species in critically ill patients, particularly those with underlying Influenza infection, should not necessarily be disregarded as contaminants or colonizers. Further research is needed to better understand the immunological relationship between Influenza and IPA for improved prevention and treatment of Influenza and Aspergillus co-infections.

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