Diabetic Macular Edema

Cunha‐Vaz, José

doi:10.1177/112067219800800301

Cited by 44 publications

(26 citation statements)

References 4 publications

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“…Pathological increases in vascular leakage are features of diabetic retinopathies, 12 rheumatoid arthritis, 13 and acute respiratory distress syndrome. 14 VEGF and its receptors are overexpressed in these diseases.…”

Section: Terai Et Al Vascular Leakage In Kawasaki Disease 327mentioning

confidence: 99%

Prognostic Impact of Vascular Leakage in Acute Kawasaki Disease

et al. 2003

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Background-Increased microvascular permeability is an initial step of Kawasaki disease (KD). We reported that vascular endothelial growth factor (VEGF) might play a role in the vascular leakage of KD. In fatal KD, plasma leakage was extensively documented at VEGF-positive microvessels. Increases in vascular leakage cause hypoalbuminemia and noncardiogenic edema. However, the prognostic impact of vascular leakage in KD remains unclear. Methods and Results-We compared 76 patients who became afebrile within 5 days after starting intravenous gamma globulin (IVGG) (2 g/kg over 5 days) (IVGG-responsive) with 27 patients who did not respond (IVGG-resistant). Baseline levels of serum VEGF and albumin were similar between the groups. After IVGG, VEGF levels increased (PϽ0.0001) and albumin levels decreased (PϽ0.00001) in both groups. However, the IVGG-resistant group had higher VEGF levels (Pϭ0.029) and severe hypoalbuminemia (PϽ0.00001) compared with the IVGG-responsive group. Coronary aneurysms were documented in 12 patients from the IVGG-resistant group but not in the IVGG-responsive group. Then IVGG-resistant patients were divided into 2 subgroups according to the presence (nϭ12) or absence (nϭ15) of coronary aneurysms. There was no difference between subgroups in age, sex, laboratory data including albumin, and retreated doses of IVGG. However, body weight gain after IVGG was documented in patients who subsequently developed coronary aneurysms (Pϭ0.003) but not in those who did not (Pϭ0.967). Conclusions-These

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Section: Terai Et Al Vascular Leakage In Kawasaki Disease 327mentioning

confidence: 99%

Prognostic Impact of Vascular Leakage in Acute Kawasaki Disease

et al. 2003

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“…Vasogenic retinal edema is directly associated with breakdown of the blood-retinal barrier (BRB) [9]. Medical therapy of vasogenic retinal edema may be targeted to act directly on BRB function using corticoids, lazaroids or acetazolamide, but these drugs must be used with caution in the management of diabetes mellitus.…”

Section: Therapeutic Strategies For Diabetic Retinopathymentioning

confidence: 99%

Medical Treatment of Retinopathy of Type-2 Diabetes

Cunha-Vaz¹

2004

Ophthalmologica

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The medical treatment of retinopathy in type-2 diabetes should be considered as a major component in the overall management of diabetic retinal disease. It is clear that specific and timely interventions, such as glycemic and blood pressure control, are the basis for good management of diabetic retinopathy. The American Diabetes Association has developed specific recommendations concerning diabetic retinopathy for the primary care physician and diabetologist. The ophthalmologist must be aware of these recommendations and establish efficient communication channels with the colleagues who follow their patients and the progression of diabetes closely. The challenge for the ophthalmologist is to make sure that, when signs of retinopathy are detected, information regarding the status of the retina, prognostic factors and the rate of progression must be given to the primary care physician and diabetologist. Under these circumstances, excellent glycemic control, aggressive management of blood pressure and normalization of lipids are all needed, and the goals to be achieved must be shared between the ophthalmologist and the primary care physician or diabetologist. Appropriate medical management of diabetic retinopathy is fundamental to reduce the risk of blindness. This goal can only be achieved if the ophthalmologist is fully aware of the role of medical management and establishes an efficient flow of communication with the primary care physician or diabetologist, particularly for the diabetic patients whose eyes show signs of risk for rapid progression of their retinopathy.

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“…Physicians have advanced diagnostic tools to evaluate their patients' cases in order to plan different forms of medical management and monitor the progress more efficiently (Schneider et al, 2012). In particular, the investigation and the analysis of eye fundus image in the object of determining the impact of diabetes on the vision system is becoming more significant (Walter et al, 2002;Cunha-Vaz, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…The rapid increase of diabetes pushes the limits of the current DR/DME screening capabilities for which the digital imaging of the eye fundus and automatic or semi-automatic image analysis algorithms provide a potential solution. The retina lesions and abnormalities that can be detected using the methods of eye fundus images are hard exudate, soft exudates, microaneurysms, and hemorrhages (Walter et al, 2002;Cunha-Vaz, 1998;Geetan, Acharya, & Ng, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The most common complications of diabetes are diabetic retinopathy (DR), and diabetic macular edema (DME), which are considered one of the primary causes of blindness and visual impairment in adults (Cunha-Vaz, 1998;Tasman & Jaeger, 2001). The rapid increase of diabetes pushes the limits of the current DR/DME screening capabilities for which the digital imaging of the eye fundus and automatic or semi-automatic image analysis algorithms provide a potential solution.…”

Section: Introductionmentioning

confidence: 99%

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Automatic Exudate Detection Using Eye Fundus Image Analysis Due to Diabetic Retinopathy

Garaibeh

Al-Smadi

Al‐Jarrah

2014

CIS

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Diabetic retinopathy (damage to the retina) is a disease caused by complications of diabetes, which can eventually lead to blindness. It is an ocular manifestation of diabetes, a systemic disease, which affects up to 80 percent of all patients who have had diabetes for 10 years or more. Despite these intimidating statistics, research indicates that at least 90% of these new cases could be reduced if there was proper and vigilant treatment and monitoring of the patient eyes. The longer a person has diabetes, the higher his or her chances of developing diabetic retinopathy. In this paper, we introduced a new method for eye fundus image analysis, based on exudate segmentation. The proposed algorithm detects the existence of exudates and measures its distribution. In this paper, we classified images of eye fundus into no-exudate or have exudates. This initial classification helps physicians to initiate a treatment process for infected patients. The algorithm is tested using DIARETDB0. The results proved the reliability and robustness of algorithm.

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Diabetic Macular Edema

Cited by 44 publications

References 4 publications

Prognostic Impact of Vascular Leakage in Acute Kawasaki Disease

Prognostic Impact of Vascular Leakage in Acute Kawasaki Disease

Medical Treatment of Retinopathy of Type-2 Diabetes

Automatic Exudate Detection Using Eye Fundus Image Analysis Due to Diabetic Retinopathy

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