Diabetic maculopathy caused by disturbances in retinal vasomotion. A new hypothesis

The relationship of retinal vascular calibre to diabetes and retinopathy: the Australian Diabetes, Obesity and Lifestyle (AusDiab) study

“…Our findings of wider arterioles in people with retinopathy corroborates findings in studies from Denmark [29,30] and Iceland that support a hypothesis that a disturbance in the autoregulation of retinal arterioles resulting in arteriolar dilatation may be the cause of hyper-fusion, haemorrhage and microaneurysm formation resulting in macular oedema [31][32][33].…”

The Systemic Blood Pressure and Oxygen Saturation in Retinal Arterioles Predict the Effect of Intravitreal Anti-VEGF Treatment on Diabetic Maculopathy

“…Thus, the measurements of oxygen saturation and diameters in the larger retinal vessels were not performed repeatedly, and, therefore, an influence of dynamic properties of vascular function to the observed effects may have been overlooked. [26][27][28] Additionally, the relationship between increasing CRT and decreasing VA after anti-VEGF treatment can be explained only partially by the findings. Thus, a positive predictive value of VA and CRT before treatment for the same parameters after treatment can be interpreted that the more deranged these parameters were before treatment, the more likely it was that the parameters also were deranged after treatment.…”

Lack of correlation between short-term dynamics of diabetic retinopathy lesions and the arterial blood pressure

“…However, diabetic retinopathy also displays a dynamic pattern of new formation and resorption of lesions with a turn-over within days to weeks, and it is likely that these changes may reflect basic pathophysiological mechanisms underlying the disease [10]. It remains to be elucidated whether the known long-term risk factors for the progression of the disease also display short-term dynamic changes that could explain the short-term dynamic changes in diabetic retinopathy.…”