Diabetic Mastopathy: An Uncommon Complication of Diabetes Mellitus

Kirby, Rita; Mitchell, D. I. G.; Williams, Nadia P.; Cornwall, D; Cawich, Shamir O

doi:10.1155/2013/198502

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…Once a histological diagnosis is confirmed, conservative non-surgical management and followup are generally accepted and recommended. Although in some cases, it may be needed, surgical excision may lead to a recurrence and should be evaluated on a case-by-case basis [6][7][17][18]. In our case, given the significant family history, the patient opted for surgical management to ensure no malignancy existed.…”

Section: Discussionmentioning

confidence: 91%

Diabetic Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma

Alkhudairi

Abdullah

Alselais

2020

Cureus

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Diabetic mastopathy is a rare benign breast condition. It is strongly associated with type I diabetes mellitus and commonly presents similar to malignancy. Here, we report a case of a 29year-old Saudi female with a long history of type I diabetes mellitus (DM) who presented with a painless hard breast mass and had a strong family history of breast cancer. Further evaluation with ultrasound (US) imaging revealed a highly suspicious, ill-defined hypoechoic lesion. Mammographic examination revealed that both breasts were of normal shape with bilateral dense glandular parenchyma. US-guided true-cut biopsy was carried out, which showed acellular fibro-sclerotic tissues with normal-looking lobules and ducts surrounding by a dense lymphocytic infiltrate. Subsequently, a diagnosis of diabetic mastopathy was established. Results were discussed with the patient, and an agreement was reached to proceed with an excisional biopsy for further reassurance and exclusion of malignancy. Local surgical excision of the lesion was performed and histopathological examination revealed extensive fibrosis of the specimen with no cellular atypia. Awareness of such a condition, with its clinical, radiographical, and histopathological characteristics, is essential in order to alleviate the patient's anxiety and avoid unnecessary surgical interventions.

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Section: Discussionmentioning

confidence: 91%

Diabetic Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma

Alkhudairi

Abdullah

Alselais

2020

Cureus

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“…Patients with type 1 diabetes who have had the condition for a long time may develop diabetic mastopathy (DMP), presenting as hard, diffuse enlargements in one or both breasts [ 32 ]. The exact cause of DMP remains unknown, but the condition is believed to be a type of auto-immune reaction.…”

Section: Etiology Of Gm In Adolescent Boys ( Table 1 ...mentioning

confidence: 99%

Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment

Metwalley,

Farghaly

2024

Ann Pediatr Endocrinol Metab

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Gynecomastia (GM) is a common and continuously evolving condition that commonly occurs during adolescence. It is the source of significant embarrassment and psychological stress in adolescent males. GM is characterized by enlargement of the male breast due to the proliferation of glandular ducts and stromal components. The main cause of GM during adolescence is physiological or pubertal GM, which is primarily attributed to an imbalance between estrogen and androgen activity. Physiological GM is typically transient and resolves within several months, although it may take several years to resolve. GM may also be caused by other pathological conditions and could be indicative of an endocrine disease. It is crucial to understand the pathogenesis of GM to distinguish it from normal developmental variants due to pathological causes. The aim of this review is to highlight the significance of GM during adolescence in terms of potential etiologies, clinical and laboratory diagnoses, and current management.

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Pathological manifestations of granulomatous lobular mastitis

Cui,

Sun,

Guo

et al. 2024

Front. Med.

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Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM is often misdiagnosed as breast cancer due to the lack of specificity in clinical and imaging examinations, and therefore histopathology is the main basis for confirming the diagnosis. This review provides an overview of the pathological features of granulomatous lobular mastitis and cystic neutrophil granulomatous mastitis (CNGM, a pathologic subtype of GLM). As well as pathologic manifestations of other breast diseases that need to be differentiated from granulomatous lobular mastitis such as breast tuberculosis, lymphocytic mastopathy/diabetic mastopathy, IgG4-related sclerosing mastitis (IgG4-RSM), nodular disease, Wegener’s granulomatosis, and plasma cell mastitis. Besides, discusses GLM and CNGM, GLM and breast cancer, emphasizing that their relationship deserves further in-depth exploration. The pathogenesis of GLM has not yet been clearly articulated and needs to be further explored, pathology enables direct observation of the microscopic manifestations of the disease and contributes to further investigation of the pathogenesis.

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Diabetic Mastopathy: An Uncommon Complication of Diabetes Mellitus

Cited by 5 publications

References 23 publications

Diabetic Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma

Diabetic Mastopathy in a Patient with High Risk of Breast Carcinoma: A Management Dilemma

Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment

Pathological manifestations of granulomatous lobular mastitis

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