Diabetic Mastopathy: Reporting an Unusual Scenario of a Rare Disease

Saleh, Mahmoud; Abdelwahab, Khaled; Ellabban, Mohamed; Hassan, Amany; Elnahas, Waleed

doi:10.1007/s13193-021-01337-1

Cited by 4 publications

(2 citation statements)

References 4 publications

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“…Core biopsy is suggested for pathological diagnosis 7 . The pathology shows lymphocytic lobulitis, ductitis and perivasculitis with stromal fibrosis 7–9 . Surgical excision is not mandatory in diabetic mastopathy because there is no increased risk of developing breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes

Li,

Chan

2024

Surgical Practice

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Diabetic mastopathy is a rare benign breast condition that mimics breast carcinoma in patients with diabetes. Clinicians must differentiate it from malignant causes because of differences in prognosis and management. This paper presents a case report of an 87‐year‐old lady with type 2 diabetes and diabetic mastopathy. We also review the literature on the pathogenesis, clinical presentation, diagnostic workup and management of diabetic mastopathy.

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Section: Discussionmentioning

confidence: 99%

Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes

Li,

Chan

2024

Surgical Practice

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“…Diabetic mastopathy, also known as fibrous mastopathy, is a rare condition that comprises less than 1% of benign breast pathologies and is a known complication of type 1 diabetes mellitus (T1DM) [1]. This disease affects 0.6% to 13% of young and middle-aged premenopausal females with T1DM, but there have been infrequent reports of diabetic mastopathy occurring in patients with type 2 diabetes mellitus, the elderly, and males [1][2][3][4]. Diabetic mastopathy was first described by Sloer and Khardori in 1984 and was officially named by Logan and Hoffman in 1989 [5,6].…”

Section: Introductionmentioning

confidence: 99%

Diabetic Mastopathy With an Associated History of Elevated Thyroid Peroxidase (TPO) and Antimitochondrial Antibodies (AMA)

Patel¹,

Naamo²,

Li³

et al. 2023

Cureus

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Diabetic mastopathy is an uncommon, benign breast lesion that is typically seen in patients with type 1 diabetes mellitus (T1DM). The main differential diagnosis for diabetic mastopathy is breast carcinoma, which appears similarly on clinical examination and diagnostic imaging. Although the etiology of diabetic mastopathy is poorly understood, it has been associated with several autoimmune conditions, such as Hashimoto's thyroiditis, systemic lupus erythematosus, and Sjogren's syndrome. Here, we report a case of diabetic mastopathy in a T1DM patient with an associated history of elevated thyroid peroxidase (TPO) and antimitochondrial antibody (AMA) levels, giving further support to the theory of autoimmune etiopathogenesis.

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Reasons and Mechanisms of Development of Mastopathy (Review of Literature)

Topchubaeva,

Tukhvatshin,

Ashfaque

et al. 2024

Bulletin of Science and Practice

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This review article examines the relationship between various etiological factors in the development of mastopathy. Multiple exogenous and endogenous risk factors disrupt the normal ratio of sex hormones, causing hyperestrogenism and hyperproliferation of the epithelium in breast tissue, which leads to the development of mastopathy. In the presence of polymorphism of coding genes (ESR1 and PRG), mastopathy also increases the risk of developing breast cancer. Disturbances in the ESR1 receptor gene (Estrogen Receptor 1) lead to changes in the sensitivity of receptors to hormones and even to its loss. According to the literature, polymorphism in the intronic region of the ESR1 gene is associated with the risk of fibrocystic mastopathy. The presence of polymorphism of the PRG (Progesterone Receptor Genes) gene may cause the occurrence of defective forms of PR (Progesterone Receptor) with disruption of the ligand- and hormone-binding zones, which is confirmed by the effects of progesterone in tissues. Thus, progesterone deficiency makes possible excessive proliferation of not only epithelial cells, but also the connective tissue component of the mammary gland. In this case, the expression of the progesterone receptor gene is regulated by the level of estrogen. The association of various combinations of predisposition genes indicates the presence of a specific combination of genotypes for each clinical and pathogenetic variant. In proliferative forms of mastopathy, foci with an excess content of estrogen receptors in the epithelium and high activity of cell proliferation and apoptosis are formed in the breast tissue; there is an increase in the content of alpha-estrogen receptors, a change in the relative content of alpha- and beta-estrogen receptors, A- and B-progesterone receptors; the sensitivity of the epithelium to estradiol increases; a complex of cyclin-dependent kinases, alpha-transforming and epidermal growth factors is activated; the proliferative activity of the epithelium increases; apoptosis processes are disrupted; vascularization of the parenchyma increases. All these pathological mechanisms that increase the risk of breast cancer have not yet been sufficiently studied both at the experimental and clinical level. In the treatment of mastopathy, diet therapy, psychological correction, hormonal drugs, non-hormonal drugs, such as vitamins, minerals, hepatoprotectors, diuretics, enzyme drugs, immunocorrectors, adaptogens, non-steroidal anti-inflammatory drugs, herbal remedies are used. The general disadvantages of most of the remedies used today are attempts to eliminate the causes of mastopathy rather than conducting pathogenetic treatment.

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Diabetic Mastopathy: Reporting an Unusual Scenario of a Rare Disease

Cited by 4 publications

References 4 publications

Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes

Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes

Diabetic Mastopathy With an Associated History of Elevated Thyroid Peroxidase (TPO) and Antimitochondrial Antibodies (AMA)

Reasons and Mechanisms of Development of Mastopathy (Review of Literature)

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