1983
DOI: 10.2337/diab.32.2.s83
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Diabetic Nephropathy and Arterial Hypertension: The Effect of Antihypertensive Treatment

Abstract: Our longitudinal study of urinary albumin excretion rate in long-term insulin-dependent diabetics without proteinuria (negative albustix) suggests that early detection of patients at high and low risk of developing persistent proteinuria, i.e., diabetic nephropathy, is possible by using a sensitive method for albumin determination. Our prospective studies in young insulin-dependent diabetics with diabetic nephropathy show that the rate of decline in glomerular filtration rate (GFR) varies considerably, with a … Show more

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Cited by 97 publications
(27 citation statements)
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“…Recent studies have provided encouraging evidence that control of systemic blood pressure may slow the progressive course of renal disease due to diabetes mellitus (40,41), essential hypertension (42), and intrinsic renal disease (43-44). We would suggest, however, that more specific knowledge of the intrarenal hemodynamic effects of the numerous antihypertensive drugs available to the clinician is needed before a beneficial renal outcome may be confidently predicted.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Recent studies have provided encouraging evidence that control of systemic blood pressure may slow the progressive course of renal disease due to diabetes mellitus (40,41), essential hypertension (42), and intrinsic renal disease (43-44). We would suggest, however, that more specific knowledge of the intrarenal hemodynamic effects of the numerous antihypertensive drugs available to the clinician is needed before a beneficial renal outcome may be confidently predicted.…”
Section: Discussionmentioning
confidence: 99%
“…After insertion ofthejugular catheters, isoncotic rat plasma was infused for '-25 min, in a total amount equal to 1% of body weight, followed by a reduction in infusion rate to 0. 41 ( 17).…”
Section: Methodsmentioning
confidence: 99%
“…These results sug gest that a combination of antihypertensive agents and sorbinil could act synergistically to further diminish proteinuria in strepto zocin-induced diabetic rats. Furthermore, early and aggressive antihypertensive treat ment with a combination of agents (metroprolol, hydralazine and furosemide) dimin ished blood pressure and albuminuria, thus postponing, but not preventing, end-stage re nal failure [27], Clinically, combination of antihypertensive agents and an aldose reduc tase inhibitor may provide a synergistic ther apeutic effect. …”
Section: Discussionmentioning
confidence: 99%
“…Hypertension and diabetes mellitus may occur together [27], The pres ence of both disturbances may further in crease the risk of renal complications includ ing proteinuria [22,31]. According to Ander son et al [2], 41% of young patients with type I, insulin-dependent diabetes mellitus (IDDM) develop persistent proteinuria which subsequently promotes renal failure.…”
Section: Introductionmentioning
confidence: 99%
“…Although controlling hypertension slows the rate of loss of renal function (26)(27)(28), ACE inhibitors are more effective in slowing the progressiono of diabetic nephropathy than other antihypertensive agents (29).…”
Section: Glomerular Hyperfiltrationmentioning
confidence: 99%