Diabetic Neuropathy

Zakin, Elina; Abrams, Rory; Simpson, David M.

doi:10.1055/s-0039-1688978

Cited by 97 publications

(67 citation statements)

References 69 publications

(111 reference statements)

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“…Most of the samples had type 2 diabetes, women, pain duration up to 12 years, and a mean age of 59. This is consistent with the previous theory that DN is more common in older adults (> 50 years) because of the time it takes for nerve damage and pain to occur (Zakin, Abrams, & Simpson, 2019), with an increased risk for type 2 DM patients, women, the prevalence of DN increases, and 23.5% after seven years (Iqbal et al, 2018). This suggests the need for early fuses, DN pain symptoms, especially in type 2 DM, to prevent the risk of complications.…”

Section: Sample On the Studysupporting

confidence: 92%

The effectiveness of complementary and alternative medicine therapy in reducing pain in diabetic neuropathy: A systematic review

Syahriyani

Yusuf

Syam

2021

Public Health of Indonesia

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Background: Pain is quite often felt in approximately 30 to 50% of people with diabetic neuropathy. As a result, the quality of life is low, indicated by the high morbidity and mortality rates. The availability of symptomatic pharmacological agents has the potential to have side effects and adverse effects in the elderly and in addition to the high risk of addiction. Complementary therapy and alternative medicine in chronic pain are clinically safe, cost-effective, and affordable. However, scientific evidence of its effectiveness is limited.Objective: This systematic review aims to evaluate the intervention modalities and the effectiveness of complementary and alternative medicine therapy in diabetic neuropathy pain.Methods: The searched literature databases included PubMed, ProQuest, ScienceDirect, EBSCO host, DOAJ, Clinical Key for Nursing, and Cochrane. The criteria for the article, among others, focus on complementary therapy and alternative medicine in diabetic neuropathy pain, publications in the last five years, full text, and in English. Results: Fifteen articles were identified in reporting the effectiveness of complementary therapy and alternative medicine in reducing diabetic neuropathy pain, including mindfulness-based stress reduction, mindfulness meditation, relaxation, whole-body vibration, Abzan, aerobic resistance training, nano curcumin, Citrullus colocynthis, dietary, acupuncture, laser, and reflexology.Conclusion: Most scientific evidence reports the effectiveness of complementary and alternative medicine therapies in reducing pain in diabetic neuropathy, thus strengthening its application as an adjunct to conventional medicine is needed.

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Section: Sample On the Studysupporting

confidence: 92%

The effectiveness of complementary and alternative medicine therapy in reducing pain in diabetic neuropathy: A systematic review

Syahriyani

Yusuf

Syam

2021

Public Health of Indonesia

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“…Our study found that nerve invasion was associated with impaired fasting glucose and DM, which was consistent with previous studies. Diabetes can induce damage to peripheral nerves ( 22 ). Is the damage related to nerve invasion?…”

Section: Discussionmentioning

confidence: 99%

Diabetes in Patients With Pancreatic Neuroendocrine Neoplasms

et al. 2020

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ObjectiveDiabetes mellitus (DM) is probably a risk factor for pancreatic neuroendocrine neoplasms (PNENs). However, the prevalence of DM in PNEN patients remains inconclusive. In the present study we observed the prevalence of DM and possible risk factors in PNEN patients.MethodsAfter excluding those with insulinoma, a total of 197 patients with PNENs were included. The demographic data, pathological characteristics, and data of blood biochemical tests were recorded. DM was considered if there was evidence of a fasting plasma glucose level of ≥7.0 mmol/L or a 2-h plasma glucose level of ≥11.1 mmol/L, or a history of DM at the time of PNEN diagnosis. Impaired fasting glucose was considered if fasting plasma glucose level was between 6.1 and 7.0 mmol/L.ResultsThe prevalence of DM, new-onset DM, and impaired fasting glucose were 17.26, 9.14, and 7.1%, respectively. The prevalence of DM was 26.0% in patients ≥60 years old (19/73) and 12.1% in patients <60 years old. Multivariable logistic regression analysis demonstrated that age, tumor size, and nerve invasion were independent risk factors for DM and impaired fasting glucose + DM (p < 0.05). Age, organs and nerve invasion were independent risk factors for impaired fasting glucose. Low high-density lipoprotein (HDL) was also a risk factor for incident of DM (OR = 0.15, 95%CI: 0.03–0.66). G2/G3 was an independent risk factor for DM in women.ConclusionOur data shows that the prevalence of DM is 17.26% in patients with PNENs and is 26.0% in patients ≥60 years of age after excluding insulinoma. Age, nerve invasion, tumor size, and HDL are risk factors for DM in PNEN patients.

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“…It is related to time of disease and poor glycemic control and has multifactorial pathogenesis. Early diagnosis is a key factor to manage this condition, and slowing its progression by modifying risk factors is the prevalent therapeutic approach (3).…”

mentioning

confidence: 99%

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

et al. 2020

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BackgroundCardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus, increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients.MethodsWe performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels <30 ng/ml received 10,000 IU/day; the ones with VD levels between 30–60 ng/ml were given 4,000 IU/day for 12 weeks.ResultsThere was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p <0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p <0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p <0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p < 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p <0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p<0.01; r= -0.5, p<0.05, respectively).ConclusionOur pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose.Clinical Trial Registrationhttp://www.isrctn.com/ISRCTN32601947, identifier ISRCTN32601947.

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Diabetic Neuropathy

Cited by 97 publications

References 69 publications

The effectiveness of complementary and alternative medicine therapy in reducing pain in diabetic neuropathy: A systematic review

The effectiveness of complementary and alternative medicine therapy in reducing pain in diabetic neuropathy: A systematic review

Diabetes in Patients With Pancreatic Neuroendocrine Neoplasms

Improvement in Cardiovascular Autonomic Neuropathy After High-Dose Vitamin D Supplementation in Patients With Type 1 Diabetes

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