Diabetic neuropathy and the sensory apparatus â€œmeissner corpuscle and merkel cellsâ€

Alsunousi, Salma; Marrif, Husnia

doi:10.3389/fnana.2014.00079

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…13, 14, 33, 34 Changes in MC densities correlate with changes in axon terminals of both myelinated and unmyelinated fibers. 11, 16, 17 Therefore, it stands to reason that MC density in the skin would be a useful marker of early diabetic DSP, a conclusion supported by biopsy studies and expanded upon with the present study. 11, 16, 17 …”

Section: Discussionsupporting

confidence: 77%

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In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

Creigh

McDermott

Sowden

et al. 2017

Journal of the Neurological Sciences

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Objective To evaluate in-vivo reflectance confocal microscopy (RCM) of Meissner’s corpuscles (MC) in diabetic distal symmetric polyneuropathy (DSP). Methods Forty-three adults with diabetes and 21 control subjects underwent RCM of MC density at the fingertip of digit V, thenar eminence (TE), and arch of the foot, ankle skin biopsy for epidermal nerve fiber density (ENFD), electrophysiological studies, monofilament threshold testing, and timed vibration at the toe. Subjects with diabetes were subdivided into groups with and without clinical DSP using the American Academy of Neurology (AAN) case definition and neuropathy outcomes were compared across groups. Results Both diabetic groups (with and without AAN clinical DSP criteria) had objective evidence of peripheral sensory involvement using conventional sensory measures, although those with clinical DSP criteria had greater abnormalities. MC densities were lower in the entire diabetic group at the TE and digit V relative to controls. MC densities at all imaging sites were associated with corresponding conventional sensory measures. MC densities were reduced in subjects without AAN clinical DSP criteria at the TE and digit V compared to controls whereas conventional upper limb sensory measures did not differ between these groups. Conclusions In-vivo RCM of MC density at digit V is a non-invasive, painless, objective marker in diabetes that offers a window into early large fiber sensory nerve terminal loss. Further studies are needed to determine whether RCM of MCs can identify quantitative changes in DSP associated with disease progression or treatment.

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Section: Discussionsupporting

confidence: 77%

“…11, 16, 17 Therefore, it stands to reason that MC density in the skin would be a useful marker of early diabetic DSP, a conclusion supported by biopsy studies and expanded upon with the present study. 11, 16, 17 …”

Section: Discussionsupporting

confidence: 77%

In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

Creigh

McDermott

Sowden

et al. 2017

Journal of the Neurological Sciences

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“…As a consequence of these changes with age, the skin becomes increasingly Results of multivariate analysis showing only significant hazard ratios with the respective 95% confidence interval less able to accommodate an ever-increasing volume of insulin-containing fluid. The lower rate of painful injections may also reflect skin changes with aging, which are typically characterized by progressively higher denervation processes [23].…”

Section: Discussionmentioning

confidence: 99%

Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes

et al. 2020

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“…Vibration signals may also differ between phones due to the addition of phone cases, variability in internal haptic motors, etc. Human vibration mechanoreceptors have a broad sensitivity from 5–800 Hz, with Pacinian corpuscles being responsible for high frequency vibrations and having peak sensitivity at 150–300 Hz [36] , [37] , [38] . The tested smartphone in this work produces a broad-spectrum of frequencies that are within this high sensitivity range.…”

Section: Discussionmentioning

confidence: 99%

Skin Sensitivity Assessment Using Smartphone Haptic Feedback

Torres,

Abbott,

Wang

et al. 2023

IEEE Open J. Eng. Med. Biol.

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This work presents a smartphone application to assess cutaneous sensory perception by establishing Vibrational Perception Thresholds (VPTs). Cutaneous sensory perception diagnostics allow for the early detection and symptom tracking of tactile dysfunction. However, lack of access to healthcare and the limited frequency of current screening tools can leave skin sensation impairments undiscovered or unmonitored. Methods: A 23participant cross-sectional study in subjects with a range of finger sensation tests Smartphone Established VPTs (SE-VPTs) by varying device vibrational intensity. These are compared against monofilament test scores, a clinical measure of skin sensitivity. Results: We find a strong positive correlation between SE-VPTs and monofilament scores (r s = 0.86, p = 1.65e-07). Conclusions: These results demonstrate the feasibility of using a smartphone as a skin sensation screening tool.

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Diabetic neuropathy and the sensory apparatus â€œmeissner corpuscle and merkel cellsâ€

Cited by 8 publications

References 25 publications

In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes

Skin Sensitivity Assessment Using Smartphone Haptic Feedback

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Diabetic neuropathy and the sensory apparatus â€œmeissner corpuscle and merkel cellsâ€

Cited by 8 publications

References 25 publications

In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

In-vivo reflectance confocal microscopy of Meissner's corpuscles in diabetic distal symmetric polyneuropathy

Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes

Skin Sensitivity Assessment Using Smartphone Haptic Feedback

Contact Info

Product

Resources

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Diabetic neuropathy and the sensory apparatus â€œmeissner corpuscle and merkel cellsâ€