2019
DOI: 10.1016/j.diabet.2019.04.002
|View full text |Cite
|
Sign up to set email alerts
|

Diabetic retinopathy, a vascular and inflammatory disease: Therapeutic implications

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
120
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 147 publications
(120 citation statements)
references
References 137 publications
0
120
0
Order By: Relevance
“…There is growing consensus regarding the key role of inflammation in pathogenesis of diabetic retinopathy (9,(45)(46)(47). The retina is the most metabolically active tissue in the body making it very susceptible to oxidative stress both from light-induced electron injury and oxygen free radical production leading to increased inflammation (48).…”
Section: Inflammation/immune Regulationmentioning
confidence: 99%
See 4 more Smart Citations
“…There is growing consensus regarding the key role of inflammation in pathogenesis of diabetic retinopathy (9,(45)(46)(47). The retina is the most metabolically active tissue in the body making it very susceptible to oxidative stress both from light-induced electron injury and oxygen free radical production leading to increased inflammation (48).…”
Section: Inflammation/immune Regulationmentioning
confidence: 99%
“…Indeed, diabetes and its associated hyperglycemia, insulin resistance, dyslipidemia, etc. all lead to altered biochemical pathways (polyol, AGEs, PKC, hexosamine, and renin-angiotensin system) that stimulate glial cell dysfunction (9,39,46,49). This dysfunction leads to increased inflammatory cytokines and chemokine production, aberrant growth factor signaling and ROS resulting in neuro-glial degeneration and vascular dysfunction and its associated alteration of the blood-retinal barrier, hypoxia, vascular permeability resulting in edema and angiogenesis (9).…”
Section: Inflammation/immune Regulationmentioning
confidence: 99%
See 3 more Smart Citations