Diabetic Retinopathy: Focus on Minority Populations

Barsegian, Arpine; Kotlyar, Boleslav; Lee, Justin; Salifu, Moro O.; McFarlane, Samy I.

doi:10.17352/ijcem.000027

Cited by 47 publications

(54 citation statements)

References 114 publications

(121 reference statements)

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“…Severe diabetic eye disease requiring anti-VEGF injections is more prevalent among racial/ethnic minority patients compared to white patients. [21][22][23] Thus, we would expect that the relative rates of in-person care compared to deferred care within each racial group would not show any disparities in the retina clinic. Ensuring that systems are in place to maximize care for populations at higher risk of morbidity from eye diseaseolder and racial/ethnic minority patients 24 is imperative.…”

Section: Discussionmentioning

confidence: 99%

Disparities in Eye Care Utilization During the COVID-19 Pandemic

Elam

Sidhom

Ugoh

et al. 2022

American Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Disparities in Eye Care Utilization During the COVID-19 Pandemic

Elam

Sidhom

Ugoh

et al. 2022

American Journal of Ophthalmology

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“…The major concern with diabetes is development of complications such as macrovascular-ischemic heart disease, related stroke, and peripheral artery disease and/or microvascular-related retinopathy, neuropathy, and nephropathy [ 1 ]. Diabetic retinopathy, is a slow progressing complication with multifactorial aetiology and affects approximately 80% of diabetics worldwide [ 2 ]. Chronic hyperglycemic milieu of Diabetes mellitus activates alternative pathways for excessive glucose metabolism which contribute to the pathogenesis of Diabetic retinopathy [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Vasant Kusmakar Ras, an ayurvedic herbo-mineral formulation prevents the development of diabetic retinopathy in rats

Tamoli

Kohli

Kaikini

et al. 2020

Journal of Ayurveda and Integrative Medicine

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Background Diabetic retinopathy is a slow progressing complication of diabetes mellitus with multifactorial aetiology affecting approximately 80% of diabetics worldwide. Chronic hyperglycemic milieu of Diabetes induces biochemical changes which contribute to the pathogenesis of Diabetic retinopathy. Objective The present study examined the protective effect of Vasant Kusumakar Ras , an Ayurvedic herbo-mineral formulation, in diabetic retinopathy. Materials and Methods Diabetes was induced in rats by intraperitoneal injection of streptozotocin (45 mg/kg). Rats were kept without any treatment for period of three weeks for induction of Diabetic retinopathy followed by treatment with Vasant Kusumakar Ras (11.25 mg/kg, p.o) for further 5 weeks. Fasting blood glucose levels, lipid profile and HbA1c were determined. Eye tissue homogenates were subjected to biochemical analysis to determine the levels of oxidative stress parameters (superoxide dismutase, catalase, reduced glutathione, lipid peroxidation), vascular endothelial growth factor and aldose reductase activity. Histopathological analysis of retinal tissue was conducted using Hematoxylin and Eosin staining. Results Vasant Kusumakar Ras treatment restored serum lipid profile which was altered in diabetic rats. Treatment with Vasant Kusumakar Ras significantly ameliorated the oxidative stress in eye tissue resulting in decreased lipid peroxidation and increase in endogenous antioxidant levels. Levels of aldose reductase and vascular endothelial growth factor in eye tissue were significantly decreased in Vasant Kusumakar Ras treated rats. Hematoxylin and Eosin staining indicated that the Vasant Kusumakar Ras treatment significantly restored the normal architecture of the retinal tissue. Conclusion Vasant Kusumakar Ras exhibits protective effect and prevents the development of Diabetic retinopathy through its effects on multiple biochemical pathways implicated in pathogenesis of Diabetic retinopathy.

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“…DR is a common difficulty in DM with multifaceted pathology and affects nearly 80% of diabetic victims around the world ( Barsegian et al, 2017 ). Chronic hyperglycemia triggers the alternative cascades for over glucose metabolism that participates in the pathological progression of DR ( Brownlee, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway

Shu

Huang

et al. 2021

Saudi Journal of Biological Sciences

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Background Diabetic retinopathy (DR) is a common problem in the diabetic patients due to the high blood glucose level. DR affects more number of diabetic patients worldwide with irreversible vision loss. Objective The current investigation was focused to reveal the therapeutic actions of nimbolide against the streptozotocin (STZ)-provoked DR in rats through inhibition of TLR4/NF-κB pathway. Methodology DR was provoked to the rats through administering a single dose of STZ (60 mg/kg) intraperitoneally. The DR rats were then supplemented with the 50 mg/kg of nimbolide for 60 days. The bodyweight and blood glucose level was measured using standard methods. The lipid profiles (cholesterol, TG, LDL, and HDL), inflammatory markers, and antioxidants level was detected using respective kits. The level of MCP-1, VEGF, and MMP-9 was quantified using kits. The morphometric analysis of retinal tissues were done. The mRNA expressions of target genes were studied using RT-PCR assay. Results Nimbolide treatment effective decreased the food intake and blood glucose, and improved the bodyweight of STZ-provoked animals. The levels of pro-inflammatory mediators, cholesterol, TG, LDL, and HDL, MCP-1, VEGF, and MMP-9 was remarkably suppressed by the nimbolide treatment. Nimbolide also improved the antioxidants, retinal thickness and cell numbers. The TLR4/NF-κB pathway was appreciably inhibited by the nimbolide. Conclusion Overall, our findings demonstrated that the nimbolide attenuated the STZ-provoked DR in rats through inhibiting the TLR4/NF-κB pathway.

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Diabetic Retinopathy: Focus on Minority Populations

Cited by 47 publications

References 114 publications

Disparities in Eye Care Utilization During the COVID-19 Pandemic

Disparities in Eye Care Utilization During the COVID-19 Pandemic

Vasant Kusmakar Ras, an ayurvedic herbo-mineral formulation prevents the development of diabetic retinopathy in rats

Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway

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