Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform

Ogawa, Osamu; Hiraoka, Kiyoko; Watanabe, Takahiro; Kinoshita, Junichiro; Kawasumi, Masahiko; Yoshii, Hidenori; Kawamori, Ryuzo

doi:10.1186/1475-2840-7-11

Cited by 29 publications

(39 citation statements)

References 24 publications

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“…The automatic pulse wave analyzer (Omron Colin, Tokyo, Japan) was recruited to measure baPWV and ABI, as described previously [8]. Briefly, patients were guided into the supine position on a bed and allowed to rest for at least 5 min before examination.…”

Section: Assessment Of Arterial Stiffnessmentioning

confidence: 99%

Efficacy and safety of sodium–glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus; Fukuoka Study of Ipragliflozin (FUSION)

et al. 2018

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Abstract. Sodium-glucose co-transporter-2 inhibitors are newly established anti-diabetic agents with a unique glucoselowering mechanism. In the present study, we investigated the efficacy and safety of the sodium-glucose co-transporter-2 inhibitor ipragliflozin (Ipra) for metabolic markers and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus (T2DM). This study was an investigator-initiated, open-label, single-arm, multicenter prospective study. Patients with T2DM were treated with 50 mg Ipra for 24 and 52 weeks. The primary outcome investigated was the reduction of glycated hemoglobin (HbA1c) level. The secondary outcome was the change in other metabolic and cardiovascular parameters by 24 weeks. Before and after 52 weeks of treatment, carotid intima-media thickening (IMT) was measured by echography. A total of 134 patients were recruited in the study. A 24-week treatment with 50 mg Ipra daily significantly reduced HbA1c level (-0.6%, p < 0.01). Body mass index (BMI), blood pressure and serum C-peptide were reduced significantly (p < 0.05), while serum glucagon level was unchanged. Interestingly, the serum adiponectin and high-density lipoprotein (HDL) cholesterol levels were significantly increased by Ipra. However, 52 weeks of Ipra treatment did not change carotid IMT. Multiple regression analysis revealed that the only significant contributing factor for HbA1c reduction by Ipra was baseline HbA1c level. These data suggest that Ipra decreased not only glucose level but also BMI, blood pressure and serum C-peptide, and the contributing factor for HbA1c reduction by Ipra was baseline HbA1c level. Further, Ipra improved serum adiponectin and HDL cholesterol levels.

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Section: Assessment Of Arterial Stiffnessmentioning

confidence: 99%

Efficacy and safety of sodium–glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus; Fukuoka Study of Ipragliflozin (FUSION)

et al. 2018

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“…On the other hand, association between AIx and diabetic retinopathy was not statistically significant. The clinical significance appears to be different between PWV and AIx in patients with diabetes 52 . PWV might be a marker of vascular injury caused by chronic hyperglycaemia, rather than a marker of retinopathy 51 .…”

Section: Microvascular Complicationsmentioning

confidence: 99%

Pulse wave analysis and diabetes mellitus. A systematic review

Gajdova

Karásek

Goldmannová

et al. 2017

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Cardiovascular (CV) disease is the primary cause of death in diabetic patients and one of the explanations may be increased arterial stiffness. Arterial stiffness assessment using pulse wave analysis, is a predictive factor of CV events. The aim of this paper is to review the current knowledge of relations between diabetes mellitus and pulse wave analysis. A MEDLINE search was performed to retrieve both original and review articles addressing the relations and influences on arterial stiffness in diabetics. Pulse wave analysis is considered as a gold standard in CV risk evaluation for patients at risk, especially diabetics. Arterial stiffness assessment may be helpful for choosing more aggressive diagnostic and therapeutic strategies, particularly in younger patients to reduce the incidence of CV disease in these patients.

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“…Recently, Cardoso et al demonstrated that increased central arterial stiffness measured by pulse wave velocity (PWV) is associated with the presence of microvascular complications (retinopathy and peripheral neuropathy) independently of other established determinants of aortic stiffness [21]. There was a significant positive association between the presence of diabetic retinopathy and PWV, but not with the AI of pulse waveform among Japanese type 2 diabetic patients without macroangiopathy [22]. The results of studies on type 2 diabetic patients cannot be extrapolated directly to type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

Rogowicz-Frontczak¹,

Araszkiewicz²,

Piłaciński³

et al. 2012

aoms

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A b s t r a c tIntroduction: The aim of the study was to assess carotid intima-media thickness (CIMT) as a subclinical marker of atherosclerosis and arterial stiffness in type 1 diabetic patients in relation to microangiopathy. Material and methods: We included 87 type 1 diabetic patients (44 women, 43 men), median age 34 years (interquartile range [IQR] 29-43), median disease duration 10 years (IQR: 9-14), mean ± standard deviation (SD) glycated haemoglobin (HbA 1c ) 8.4 ±1.4%. Fifty patients had at least one microangiopathic complication. Intima-media thickness (IMT) of the common carotid artery was measured using high resolution ultrasonography. Arterial stiffness was assessed using digital volume pulse analysis and tonometric measurement of wave reflection and central haemodynamics. 120.2 ±19.4% vs. 110.5 ±17.1%, p = 0.016) and higher peripheral augmentation index (PAI x ) (65.7 ±18.1% vs. 57.2 ±14.9%, p = 0.023). In the logistic regression analysis, the duration of diabetes, systolic and diastolic blood pressure, postprandial glycaemia, HbA 1c and triglycerides predicted the presence of diabetic microangiopathy independently of age and sex. The CIMT, CAI x and PAI x were associated with the presence of diabetic microangiopathy only in the univariate model. Conclusions: In type 1 diabetic patients with microangiopathic complications, increased carotid IMT and arterial stiffness were observed. The study confirms the role of traditional risk factors for late diabetic complications, such as the duration of the disease and metabolic control in the development of microangiopathy.

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Diabetic retinopathy is associated with pulse wave velocity, not with the augmentation index of pulse waveform

Abstract: Background: To investigate the clinical differences between pulse wave velocity and augmentation index in diabetic retinopathy.

Cited by 29 publications

References 24 publications

Efficacy and safety of sodium–glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus; Fukuoka Study of Ipragliflozin (FUSION)

Efficacy and safety of sodium–glucose cotransporter 2 inhibitor ipragliflozin on glycemic control and cardiovascular parameters in Japanese patients with type 2 diabetes mellitus; Fukuoka Study of Ipragliflozin (FUSION)

Pulse wave analysis and diabetes mellitus. A systematic review

Carotid intima-media thickness and arterial stiffness in type 1 diabetic patients with and without microangiopathy

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