Diabetic retinopathy is independently associated with increased risk of intubation: A single centre cohort study of patients with diabetes hospitalised with COVID-19

Corcillo, Antonella; Cohen, Siew; Li, Adrian; Crane, James; Kariyawasam, Dulmini; Karalliedde, Janaka

doi:10.1016/j.diabres.2020.108529

Cited by 38 publications

(18 citation statements)

References 7 publications

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“…Due to the nature of the study, causal link or underlying mechanism of the association was not established. However, authors speculated that diabetic microangiopathy could have been a surrogate marker of a preexisting endothelial dysfunction/damage which may represent a risk factor for an increased severity of respiratory dysfunction in COVID-19 [14].…”

Section: Diabetes Mellitus and Diabetic Retinopathymentioning

confidence: 99%

Hypovitaminosis D and the endocrine phenotype of COVID-19

Giustina

2021

Endocrine

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Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease. Aim Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19. Conclusions This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status. Keywords Vitamin D • Hypocalcemia • Vertebral fractures • Diabetes mellitus • Obesity • COVID-19

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Section: Diabetes Mellitus and Diabetic Retinopathymentioning

confidence: 99%

Hypovitaminosis D and the endocrine phenotype of COVID-19

Giustina

2021

Endocrine

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“…Nessa mesma perspectiva analítica, Corcillo et al (2021), descrevem que ao comparar os pacientes intubados com os não intubados, os resultados foram semelhantes com menor idade, menor duração do diabetes e maior prevalência de retinopatia e obesidade. Além de não evidenciar associação significativa entre a intubação e outras variáveis de fatores qualitativos como o sexo, etnia, dentre outros fatores como o uso de bloqueadores do sistema reninaangiotensina-aldosterona, tipo de diabetes, hipertensão, função renal e nível de glicose no momento da admissão.…”

Section: Resultsunclassified

Uso De Oximetria No Diagnóstico Precoce De Covid-19

Batista¹,

Silva²,

Nascimento³

et al. 2021

Estudos Sobre O Enfrentamento Da Pandemia De Covid-19 Sob Perspectivas Multiprofissionais

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“…Only a few studies have investigated the effect of individual diabetic microvascular complications on COVID-19 outcomes. A single centre study of 189 hospitalised COVID-19 patients with diabetes ( Corcillo et al, 2020 ), identified that the presence of diabetic retinopathy was associated with over five-fold increased odds of intubation (OR 5.81, 95% CI 1.37–24.66 [ P < 0.001]), independent of other well-established COVID-19 risk factors. In the study, 80% of patients with retinopathy had background retinopathy.…”

Section: Microvascular Complications Of Diabetes As a Risk Factor For Severe Covid-19mentioning

confidence: 99%

What is the impact of microvascular complications of diabetes on severe COVID-19?

Basra

Whyte

Karalliedde

et al. 2022

Microvascular Research

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Evidence suggests severe coronavirus disease-19 (COVID-19) infection is characterised by pulmonary and systemic microvasculature dysfunction, specifically, acute endothelial injury, hypercoagulation and increased capillary permeability. Diabetes, which is also characterised by vascular injury in itself, confers an increased risk of adverse COVID-19 outcomes. It has been suggested that pre-existing endothelial dysfunction and microvascular disease in diabetes will exacerbate the vascular insults associated with COVID-19 and thus lead to increased severity of COVID-19 infection. In this article, we evaluate the current evidence exploring the impact of microvascular complications, in the form of diabetic retinopathy and nephropathy, in individuals with COVID-19 and diabetes. Future insights gained from exploring the microvascular injury patterns and clinical outcomes may come to influence care delivery algorithms for either of these conditions.

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Diabetic retinopathy is independently associated with increased risk of intubation: A single centre cohort study of patients with diabetes hospitalised with COVID-19

Cited by 38 publications

References 7 publications

Hypovitaminosis D and the endocrine phenotype of COVID-19

Hypovitaminosis D and the endocrine phenotype of COVID-19

Uso De Oximetria No Diagnóstico Precoce De Covid-19

What is the impact of microvascular complications of diabetes on severe COVID-19?

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