Diabetic Wound Imaging Using a Noncontact Near-Infrared Scanner

Godavarty, Anuradha; Rao, Pallela Narayana Someshwara; Khandavilli, Y.; Jung, Young–Jin

doi:10.1177/1932296815590828

Cited by 19 publications

(15 citation statements)

References 2 publications

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“…Optical imaging provides a desirable alternative to imaging of infections [10]. Recent studies using optical imaging in infection have produced some promising results for diabetic wound healing and infection [26,27]. The use of a radiopharmaceutical or optical imaging agent for evaluation of infection is dictated by some factors that include: • Type, site and extent of infection • Pathology of the infection • Pathophysiology of concomitant conditions • Clinical problem clinicians encounter in a particular infection…”

Section: Metabolic Imaging In Dfismentioning

confidence: 99%

New Imaging Tracers for the Infected Diabetic Foot (Nuclear and Optical Imaging)

Ankrah

Klein

Elsinga

2018

CPD

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Diabetic Foot Infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate treatment of the infected diabetic foot is crucial. The determination of DFIs, however, may be quite perplexing and invasive. Imaging is useful in the evaluation of certain cases of DFIs, especially in suspected instances with no overt clinical features, or in the diagnosis of osteomyelitis. Nuclear medicine imaging is currently used in the evaluation of DFIs; however, like all the imaging techniques now available, it has its limitations. Several radiopharmaceuticals presently available play useful roles in the management of DFIs, while new ones are being evaluated. Optical imaging techniques have recently demonstrated promising results in the evaluation of many infections including DFIs. Using the same molecule, a tracer can be labeled with a radioisotope or an optical imaging dye. This enables infections to be evaluated both pre- and intra-operatively when surgery is required in their management. In some cases, tracers have been simultaneously labeled with both a radioisotope and an optical imaging dye to produce a hybrid tracer. These new tracers potentially provide powerful and new opportunities in the management of DFIs. In this review, we briefly examine tracers that have been used in the evaluation of the infected diabetic foot. We then explore the potential of new imaging tracers currently under development for infection that may be useful in the management of DFIs.

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Section: Metabolic Imaging In Dfismentioning

confidence: 99%

New Imaging Tracers for the Infected Diabetic Foot (Nuclear and Optical Imaging)

Ankrah

Klein

Elsinga

2018

CPD

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“…Several research groups have implemented NIR optical imaging technology on wound imaging (chronic wounds and DFUs) with animal studies as well as pilot human subject studies. 5,[7][8][9][10][11][12][13][14][15][16][17] A summary of all the studies conducted with implementation of NIRS is listed in Table 1. Papazoglou's group and Weingarten's group at Drexel University conducted animal studies and a pilot human study to show that NIRS is capable of predicting wound healing in DFUs. [8][9][10][11][12][13][14] Moza et al developed a multiwavelength imager (no contact at the source end, but contact at the detector end) with real-time imaging display and demonstrated that NIRS is capable of imaging perfusion from studies on normal hands.…”

Section: Near-infrared Optical Imagingmentioning

confidence: 99%

“…Recently, a near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory, which is capable of noncontact whole wound imaging in real time. 16,17 Preliminary case studies demonstrated its ability to differentiate a healing from nonhealing wound based on differences in the optical contrast in lower extremity ulcers (DFUs and VLUs). [16][17][18] However, these preliminary studies were based on qualitative assessment of healing or nonhealing without assessing the effect of varying imaging conditions and image analysis in a clinic setting.…”

Section: Near-infrared Optical Imagingmentioning

confidence: 99%

“…16,17 Preliminary case studies demonstrated its ability to differentiate a healing from nonhealing wound based on differences in the optical contrast in lower extremity ulcers (DFUs and VLUs). [16][17][18] However, these preliminary studies were based on qualitative assessment of healing or nonhealing without assessing the effect of varying imaging conditions and image analysis in a clinic setting. The current research focuses on applying NIROS to image VLUs and determine its ability to assess the healing or nonhealing nature consistently, under varying imaging and analysis conditions.…”

Section: Near-infrared Optical Imagingmentioning

confidence: 99%

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Assessing the Healing of Venous Leg Ulcers Using a Noncontact Near-Infrared Optical Imaging Approach

Lei

Rodríguez

Jayachandran

et al. 2018

Advances in Wound Care

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Venous leg ulcers (VLUs) are one of the most common complications in lower extremity wounds. To date, clinicians employ visual inspection of the wound site during its healing process by monitoring surface granulation and reduction in wound size across weeks of treatment. In this study, a handheld near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory to differentiate healing from nonhealing VLUs based on differences in blood flow to the wound and its surroundings. Noncontact near-infrared (NIR) area imaging of 12 VLUs have been carried out at two podiatric clinics. Diffuse reflectance images of the wounds were used to quantify optical contrasts between the wound and its surroundings. The variability in imaging conditions, analysis, and operator dependency were assessed to determine the robustness of the imaging approach. Optical contrast obtained from diffuse reflectance images of VLUs were distinctly different for healing (positive contrast) and nonhealing (negative contrast) wounds, independent of the varying imaging and data analysis conditions. NIR imaging of wounds to differentiate healing from nonhealing VLUs using a noncontact wide-area imager has been demonstrated for the first time. The application of a portable handheld imager to assess the healing or nonhealing nature of VLUs during weekly clinical treatment is significant since physiological changes, as observed using NIROS, manifest before visual reduction in wound size during the healing process.

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“…This qualitative comparison states that NIR imaging of wounds can differentiate healing and nonhealing regions of the wound. 56 Currently, extensive imaging studies are ongoing to develop quantitative metrics to differentiate healing and nonhealing regions of the wound from background using NIR as well as hemodynamic information.…”

Section: Wound Imaging Studies At Optical Imaging Laboratorymentioning

confidence: 99%