DIABETOGENIC EFFECT OF PURIFIED GROWTH HORMONE<sup>1</sup>,<sup>2</sup>

Campbell, James E.; Davidson, I. W. F.; Snair, W. D.; Lei, Hao

doi:10.1210/endo-46-3-273

Cited by 64 publications

(13 citation statements)

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“…The possibility of corticotropin contamination has been considered. It is interesting in this connection that both Houssay and Anderson 18 and Campbell and others 19 failed to produce definite diabetes in the dog and cat with corticotropin, yet it can be readily produced by growth hormone.…”

Section: Hyperglycemia Following the Administration Of Pituitary Extrmentioning

confidence: 90%

Diabetes of Anterior Pituitary and Adrenal Cortical Origin

1954

Diabetes

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Section: Hyperglycemia Following the Administration Of Pituitary Extrmentioning

confidence: 90%

Diabetes of Anterior Pituitary and Adrenal Cortical Origin

1954

Diabetes

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“…This possibility, however, received little support from data for blood-sugar levels ( Table 6). DISCUSSION Ineffectiveness of ACTH as a diabetogenic agent in the cat ACTH is more effective than GH as a 'diabetogenic' agent in the alloxan-diabetic rat [Bennett & Li, 1947], in contrast to the partially depancreatized cat [Houssay & Anderson, 1949] or the intact dog [Campbell et al 1950]. Under the conditions now used, in cats with an intact pancreas, no glycosuria or hyperglycaemia was induced potentiated by) ACTH * Blood-sugar determined by Hagedorn-Jensen method on ear-vein samples, usually taken 22 hr after injection, with a minimum fast of 3 hr.…”

Section: Comparison Of Different Gh Preparations In the Experiments mentioning

confidence: 99%

“…Purified preparations of the anterior pituitary growth hormone (GH) are diabetogenic in the intact cat [Cotes, Reid & Young, 1949;Milman & de Moor, 1950], and in the intact dog [Campbell, Davidson, Snair & Lei, 1950;Lockett, Reid & Young, 1953]. A diabetogenic action of adrenocorticotrophin (ACTH) has been demonstrated in the force-fed intact rat [Ingle, Li & Evans, 1946], in the ahoxan-diabetic rat [Bennett & Li, 1947] and in man [Conn, Louis & Wheeler, 1948].…”

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confidence: 99%

Adrenocorticotrophin in Relation to the Diabetogenic Activity of Growth Hormone Preparations

Reid¹

1953

J Endocrinol

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The diabetogenic activity of preparations of growth hormone (GH) in intact cats was enhanced by the additional administration of preparations of adrenocorticotrophin (ACTH). High doses of ACTH alone were not diabetogenic under these conditions. The enhancing action of ACTH occasionally persisted for some time after cessation of ACTH injections, and was not associated with any marked lowering of the renal threshold for glucose.With a given ACTH preparation, the diabetogenic activity of purified GH was usually enhanced less than that of crude preparations.With a given GH preparation, the degree of enhancement differed with different ACTH preparations, and bore little relation to their effectiveness in the Sayers test. Experiments are in progress to test the possibility that these differences might merely reflect differences in the rate of absorption from the injection site.The experiments were performed in adult cats with an intact pancreas, under test conditions of which details have been given elsewhere [Reid, 1951 c]. Male or castratemale cats were usually employed, but anoestrous females were used in a few instances with results similar to those obtained in males. The cats were fed on a meat diet, the daily intake of which was kept almost constant. Any experiment which resulted in severe anorexia was considered invalid.Injections were given subcutaneously, and at different sites if two test substances were being administered concurrently. GH preparations were given once daily, and ACTH preparations usually three times per day (over 8 hr). Each period of treatment with GH was terminated when a glucose excretion exceeding 5 g in 24 hr was obtained, and the next test was commenced only when the urine had been free of sugar for at least 6 days. Ketonuria was not observed in any of the experiments reported below.

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“…The immediate effects of growth hormone on the blood sugar of the normal animal are often very small, especially in the rat and the mouse [Houssay & Anderson, 1949]. Growth hormone has, however, been shown to raise the blood sugar level (often permanently) in many species [Campbell, Davidson, Snair & Lei, 1950;Mayer, Russell, Bates & Dickie, 1953;Cavallero & Malandrà, 1953], but the process often takes several days, and requires very large doses of growth hormone, partial pancreatectomy or force feeding with carbohydrate. It has also been reported that growth hormone lowers the blood sugar of normal and of hypophysectomized animals [Marx, Herring & Evans, 1944;Kurtz, de Bodo, Kiang & Ancowitz, 1951], and that it increases the rate of uptake of glucose by normal and by hypophysectomized rat diaphragm [Ottaway, 1951 ;Krahl, 1951].…”

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confidence: 99%

Pituitary Growth Hormone and the Glucose Utilization of Rat Diaphragm

Ottaway¹,

Bulbrook²

1955

Journal of Endocrinology

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Growth hormone has been reported to cause either a depression or a stimulation of the glucose uptake of isolated rat diaphragm. The present paper describes further work on the two effects.1. Anaerobic conditions during the preparation of the diaphragm for incubation affect the glucose uptake and alter the response of the muscle to growth hormone. By controlling the oxygen tension in the diaphragm immediately after excision, variation of the glucose uptake and the effect of the hormone is reduced.2. Solutions of growth hormone were found to be extremely labile, but, by rigidly standardizing the method of preparing solutions, consistent results were obtained.3. The relationship between the concentration of growth hormone and its effect on the glucose uptake of isolated diaphragm was investigated separately for muscle saturated with oxygen and with nitrogen. With oxygenated muscle at high concentrations the hormone stimulates, and at low concentrations depresses, the rate of glucose uptake.4. The mode of action of growth hormone in vitro and in vivo is discussed.

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DIABETOGENIC EFFECT OF PURIFIED GROWTH HORMONE¹,²

Cited by 64 publications

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Diabetes of Anterior Pituitary and Adrenal Cortical Origin

Diabetes of Anterior Pituitary and Adrenal Cortical Origin

Adrenocorticotrophin in Relation to the Diabetogenic Activity of Growth Hormone Preparations

Pituitary Growth Hormone and the Glucose Utilization of Rat Diaphragm

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DIABETOGENIC EFFECT OF PURIFIED GROWTH HORMONE1,2

Cited by 64 publications

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Diabetes of Anterior Pituitary and Adrenal Cortical Origin

Diabetes of Anterior Pituitary and Adrenal Cortical Origin

Adrenocorticotrophin in Relation to the Diabetogenic Activity of Growth Hormone Preparations

Pituitary Growth Hormone and the Glucose Utilization of Rat Diaphragm

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DIABETOGENIC EFFECT OF PURIFIED GROWTH HORMONE¹,²