Diacerein in the treatment of osteoarthritis in patients with comorbidity

Шарапова, Е. П.; Алексеева, Л. И.; Лила, А. М.

doi:10.14412/1996-7012-2018-4-54-58

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Their outcomes parameters were radiographic evaluation of the joint.14 In another study by Sharapova et al reported that diacerein showed good outcomes in improving pain and functional disability among patients. 15 Karateev et al conducted study on 100 cases with primary knee osteoarthritis and divided patients in two groups, one group was given conventional treatment and second group given diacerein plus conventional treatment. They concluded that 60% cases receiving diacerein plus conventional treatment showed good outcomes as compared to 20% cases receiving just conventional treatment.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Diacerein in Primary Knee Osteoarthritis

Naqvi¹,

Cheema²,

Latif³

et al. 2022

PJMHS

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Objective: To determine role of diacerein among the patient with primary knee osteoarthritis (KOA). Study Design: An observational cohort study. Place and Duration: Department of orthopedic surgery, Sughra Shafi Medical Complex, Narowal from June 2021 to May 2022. Materials and Methods: A total of 100 patients of either gender visiting outpatient department with primary KOA aged 50-75 years were enrolled. Patients were assessed as per Western Ontario and McMaster Universities Arthritis Index (WOMAC) and visual analogue scale (VAS). Diacerein was prescribed 100 mg two times a day for a total duration of six months. WOMAC and VAS were noted before and after completion of the 6 months follow up period. Results: In a total of 100 patients, 56 (56.0%) were female. Mean age was 63.58 ± 6.42 years while mean BMI was 29.46±3.42 kg/m2. There were 50 (50.0%) patients who belonged to middle socioeconomic status. Grade of KOA was II in 54 (54.0%) patients. Baseline WOMAC score was 45.12±6.68 while baseline VAS was noted to be 6.81±2.76. At the end of the 6-month treatment period, 83 patients completed the treatment span and so were included in the final analysis. It was found that significant reduction in both WOMAC score (p<0.0001) and VAS (p<0.0001) were found among the studied patients. Practical Implications: Diacerein seems to be a good option for relief in symptoms against patients suffering with primary knee osteoarthritis but further randomized trials should be conducted to verify the findings of this study. Conclusion: Diacerein resulted in significant improvement in the mean WOMAC and VAS scores after six months therapy. Keywords: Diacerein, improvement, Osteoarthritis Knee, VAS, WOMAC

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Diacerein in Primary Knee Osteoarthritis

Naqvi¹,

Cheema²,

Latif³

et al. 2022

PJMHS

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“…This applies particularly to such diseases as acute/chronic rheumatic fever and rheumatoid arthritis. Late diagnosis of psychiatric disorders complicates the possibility of providing a qualified medical assistance for patients, adversely affecting the further rehabilitation, and impairs social consequences of rheumatic diseases [11][12][13][14]. The psy-chopathological study assessing this pathology is of great importance since mental disorders affect the psychological state of patients [15,16,[21][22][23][24].…”

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confidence: 99%

Psychocorrection of psychic and psychopathological disorders in rheumatologic pathology

Kozidubova

Doluda

Honcharov

et al. 2020

ZMJ

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Ревматична патологія -одна з найбільш актуальних проблем сучасної медицини у зв'язку з впливом захворювань цієї групи на якість життя пацієнтів, оскільки призводить до інвалідизації.Мета роботи -розробити комплекс психокорекції порушень на підставі системного аналізу клініко-психопатологічних і патопсихологічних особливостей пацієнтів із ревматичною патологією.Матеріали та методи. Обстежили 124 особи, середній вік -39,5 року; 99 пацієнтів із ревматичною патологією включили в основну групу в період рандомізації. Перша група включала 48 пацієнтів із гострою/хронічною ревматичною лихоманкою (R), друга -51 пацієнт із ревматоїдним артритом (RA). У 25 пацієнтів із ревматичною патологією не виявили психічні розлади, тому вони не були рандомізовані. Клініко-психопатологічний метод використовували для виявлення різних рівнів психопатології відповідно до МКХ-10. Психодіагностичні методи застосовували для вивчення патопсихологічних характеристик пацієнтів: тест Люшера -для вивчення та оцінювання індивідуального й емоційного стану пацієнтів (Собчик Л., 2002); колірний тест відносин (КТВ) -для виявлення емоційних компонентів ставлення пацієнта до значущого оточення та самого себе (Бажин Е. Ф., Еткінд А. М., 1985); тест Кеттелла -для виявлення характеристик особистості (16 PF, форма A), шкала самооцінки Т. Дембо і С. Дж. Рубінштейна (Bleyher В. М., Крук І. В., 1986) -для оцінювання критичних навичок. Індивідуальні психокорекційні комплекси включали методи м'язової релаксації Якобсона та аутогенного тренування, техніки саморегуляції, навички емоційної релаксації, перемикання уваги.

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Pleiotropic effects of diacerein in comorbid patients with osteoarthritis

Belyaeva

Mazurov

2022

Sovremennaâ revmatologiâ

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The article presents an analysis of the therapeutic effect of the drug diacerein (D), which has been used in osteoarthritis (OA) for more than 20 years and is included in the clinical guidelines of the Association of Rheumatologists of Russia (2021) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal diseases (ESCEO, 2019) for the treatment of OA. The main pathogenic effect of D in OA is to suppress the synthesis of interleukin 1, stimulate the production of articular cartilage proteoglycans, and slow down abnormal remodeling of the subchondral bone. The advantages of D in the treatment of patients with OA and comorbidities are presented – a prolonged anti-inflammatory and analgesic effect and good tolerability. These properties of D allow to control the symptoms of OA and improve the quality of life of patients. The structure-modifying effect of D is based on its ability to stimulate the synthesis of articular cartilage proteoglycans with long-term use and prevent abnormal remodeling of the subchondral bone, which leads to a decrease in the risk of OA progression and a delay in total joint arthroplasty. An important advantage of D is its positive metabolic effect in patients with type 2 diabetes mellitus and obesity, which is associated with the ability of D to reduce the level of glycated hemoglobin and body mass index. Data are presented on the absence of adverse cardiovascular effects when using D, which allows us to recommend its use in patients with OA who have comorbid cardiovascular diseases, as well as contraindications for non-steroidal anti-inflammatory drugs.

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Diacerein in the treatment of osteoarthritis in patients with comorbidity

Cited by 4 publications

References 26 publications

Effectiveness of Diacerein in Primary Knee Osteoarthritis

Effectiveness of Diacerein in Primary Knee Osteoarthritis

Psychocorrection of psychic and psychopathological disorders in rheumatologic pathology

Pleiotropic effects of diacerein in comorbid patients with osteoarthritis

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