Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: A long-term randomized, double-blind controlled study

Li, Duo; Xu, Tao; Takase, Hideto; Tokimitsu, Ichiro; Zhang, Pianhong; Wang, Qingqing; Yu, Xiaomei; Zhang, Aizhen

doi:10.1016/j.clnu.2008.01.009

Cited by 25 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Plasma lipids were determined on an autoanalyzer (Olympus AU2700, Tokyo, Japan), via commercially available kits (Olympus). Fasting serum insulin and glucose were measured by standard methods as previously described [21]. Homeostasis model assessment (HOMA) insulin resistance (IR) (HOMA-IR) was calculated using the mathematical approximations described by Matthews et al [22].…”

Section: Laboratory Measurementsmentioning

confidence: 99%

Increased plasma n‐3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China

Huang

Wahlqvist

et al. 2010

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

Increased tissue n-3 polyunsaturated fatty acid (PUFA) is associated with improved insulin sensitivity in type 2 diabetes. However, this relationship among Chinese is not clear. To investigate the relationship between plasma phospholipids (PL) fatty acid composition and insulin resistance (IR) in type 2 diabetes mellitus, 186 type 2 diabetes and 180 healthy subjects were studied in this case-control study. In the sex, age and BMI controlled partial correlation, homeostasis model assessment (HOMA)-IR and blood glucose was significantly negatively correlated with plasma PL n-3 PUFA, 20:5n-3 and ratio of n-3:n-6 (p<0.01), and positively correlated with n-6 PUFA (p<0.001) and saturated fatty acid (p<0.05) in the diabetes patients. PL 22:6n-3 was also significantly negatively correlated with HOMA-IR (p<0.01), but not with blood glucose. Fasting insulin was significantly negatively correlated with plasma PL n-3 PUFA, 20:5n-3, 22:6n-3 and ratio of n-3:n-6 (p<0.01). The 18:3n-3 was not associated with HOMA-IR and fasting insulin. The results suggested that increased plasma PL n-3 PUFA, 20:5n-3, 22:6n-3 and ratio of n-3:n-6 PUFA was associated with decreased HOMA-IR in type 2 diabetes. Increased plasma PL n-3 PUFA improves insulin sensitivity in type 2 diabetes.

show abstract

Section: Laboratory Measurementsmentioning

confidence: 99%

Increased plasma n‐3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China

Huang

Wahlqvist

et al. 2010

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…The LGIS diets also increased nonesterified fatty acid (NEFA) mobilization in the systemic circulation. Although this preliminary study found the potential to improve insulin sensitivity by starch type, several researchers reported that DAG, specifically the 1,3-DAG isomer, also elicits a positive effect on insulin sensitivity in addition to obesity reduction [12, 13]. It was, therefore, hypothesized that postprandial insulin concentrations would be lowered using a dietary combination of LGIS and DAG during canine weight loss.…”

Section: Introductionmentioning

confidence: 96%

Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss

Mitsuhashi

Nagaoka

Bigley

et al. 2012

ISRN Veterinary Science

View full text Add to dashboard Cite

Obesity increases insulin resistance and disregulation of glucose homeostasis. This study investigated low glycemic index starch (LGIS)/diacylglycerol (DAG) diet on plasma insulin and circulating incretin hormones during canine weight loss. Obese Beagle dogs were fed one of four starch/oil combination diets (LGIS/DAG; LGIS/triacylglycerol (TAG); high glycemic index starch (HGIS)/DAG; and HGIS/TAG) for 9 weeks during the weight loss period. At weeks 1 and 8, fasting plasma insulin, glucose, nonesterified fatty acid (NEFA), glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) were determined. Weight loss did not affect fasting insulin, glucose, and NEFA, but fasting GIP increased and GLP-1 decreased. LGIS affected postprandial insulin at both times and glucose was similar to insulin, except 60 min postprandially with DAG at week 8. NEFA lowering was less with the LGIS diets initially but not thereafter. At 60 min postprandially on week 8, GIP was significantly elevated by DAG, while GLP-1 was increased only with the HD diet. LGIS suppressed insulin and glucose responses up to 180 min postprandially at both sample times. DAG increased incretin hormones as did the DAG/HGIS combination but only at week 8. This latter finding appeared to be related to the glucose response but not to insulin at 60 min.

show abstract

“…Esta reação produz uma mistura com, aproximadamente, 50% de MAG. 8 Devido às altas temperaturas utilizadas, esta reação é acompanhada pela formação de subprodutos indesejáveis, decorrentes de reações de polimerização de ácidos graxos. Estes componentes conferem cor escura e odor desagradável ao óleo.…”

Section: Introductionunclassified

Produção de monoacilgliceróis e diacilgliceróis via glicerólise enzimática e destilação molecular

Fregolente¹,

Pinto²,

Wolf-Maciel³

et al. 2009

Quím. Nova

View full text Add to dashboard Cite

Recebido em 19/8/08; aceito em 20/1/09; pubicado na web em 3/7/09 PRODUCTION OF MONOGLYCERIDES AND DIGLYCERIDES THROUGH LIPASE-CATALYZED GLYCEROLYSIS AND MOLECULAR DISTILLATION. Monoacilglycerides and diacilglycerides are produced through lipase-catalyzed glycerolysis of soybean oil using Candida antarctica B in a solvent-free system. The reaction was carried out at a glycerol to triacylglycerol molar ratio of 8:1 with 2% of lipase. Acylglycerides, free fatty acids (FFA) and glycerol produced were separated employing the molecular distillation process. Starting from a product of enzymatic reaction 25.06% of triacylglycerols, 46.63% of diacylglycerides, 21.72% of monoacylglycerides, 5.38% of FFA and 1.21% of glycerol and after consecutively distillations, monoacylglycerides with 80% of purity was obtained and also oil with 54% of diacylglycerides to be used in human dietary.Keywords: monoacylglycerol; diacylglycerol; molecular distillation. INTRODUÇÃOAtualmente, a conversão de gorduras e óleos em produtos de alto valor agregado, como monoacilgliceróis, ácidos graxos livres e derivados tem sido de grande interesse comercial. Os monoacilgliceróis (MAG) equivalem a 70% dos emulsificantes utilizados nas indústrias alimentícias, cosméticas e farmacêuticas. Além dos MAG, os diacilgliceróis (DAG) apresentam aplicação como emulsificantes não-iônicos e agentes texturizadores.1 Além das características emulsificantes dos DAG similares aos MAG por serem moléculas anfifílicas, os DAG são estruturalmente similares aos triacilgliceróis (TAG), elementos majoritários (>95 %) nos óleos vegetais. Assim sendo, o óleo essencialmente de DAG pode ser incorporado na dieta humana uma vez que estes também apresentam propriedades similares ao óleo de TAG em relação ao cozimento de alimentos e estabilidade a altas temperaturas sem degradação do óleo, no caso de frituras.2,3 Pesquisas realizadas com ratos relatam que, ao contrário dos TAG que em excesso no organismo são estocados em forma de gordura localizada, os DAG são facilmente utilizados pelo organismo como fonte de energia. 4,5 No Japão, estudos clínicos têm demonstrado que o uso de óleo de DAG em substituição ao óleo de TAG não somente reduz a gordura acumulada na região abdominal como previne doenças arterioscleróticas, obesidade e resistência à insulina. 6,7 Industrialmente, MAG e DAG são produzidos através da interesterificação de triacilgliceróis com glicerol (glicerólise), a altas temperaturas (>200 °C), na presença de catalisadores inorgânicos. Esta reação produz uma mistura com, aproximadamente, 50% de MAG. 8Devido às altas temperaturas utilizadas, esta reação é acompanhada pela formação de subprodutos indesejáveis, decorrentes de reações de polimerização de ácidos graxos. Estes componentes conferem cor escura e odor desagradável ao óleo. 9Com o crescente interesse das indústrias alimentícias em fabricar produtos mais saudáveis devido às exigências de mercado, ou seja, produtos livres de reações de polimerização e de gorduras na configuração trans, a substituição da rota quím...

show abstract

Diacylglycerol-induced improvement of whole-body insulin sensitivity in type 2 diabetes mellitus: A long-term randomized, double-blind controlled study

Cited by 25 publications

References 33 publications

Increased plasma n‐3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China

Increased plasma n‐3 polyunsaturated fatty acid is associated with improved insulin sensitivity in type 2 diabetes in China

Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss

Produção de monoacilgliceróis e diacilgliceróis via glicerólise enzimática e destilação molecular

Contact Info

Product

Resources

About